Chia-Ying (James) Lin, PhD

Associate Professor, Biomedical Engineering, UC College of Engineering and Applied Science Department of Biomedical, Chemical, and Environmental Engineering

Associate Professor, Orthopaedic Surgery, UC College of Medicine Department of Orthopaedic Surgery

Associate Professor, Neurosurgery, UC College of Medicine Department of Neurosurgery

Biography

Chia-Ying Lin received his BS in Civil Engineering from National Taiwan University and his MS in Biomedical Engineering from the University of Michigan in 1997 and 2002, respectively. He earned his PhD in Biomedical Engineering from the University of Michigan in 2004.

Prior to joining UC CEAS, Lin concurrently held four positions at the University of Michigan Medical School: Director of the Spine Research Laboratory; Assistant Professor of Biomedical Engineering; Assistant Professor of Orthopaedic Surgery; and Assistant Professor of Neurosurgery. 

Lin currently holds three patents with two more in the works and has garnered numerous grants totaling over $3.2 million. He was recently appointed the Dane A. and Mary Louise Miller Chair in Biomedical Engineering. Lin is also the Director of the Skeletal Tissue Evaluation & Engineering Laboratory (STEEL) at CEAS.

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James Lin


Research Interests

  • Bone Tissue Engineering; Biomaterials; Spinal Segmental Reconstruction and Biomechanics; Intervertebral Disc Degeneration and Regeneration; and Primary and Metastatic Spine Tumors.


Professional Experience

Associate Professor, Department of Biomedical, Chemical, and Environmental Engineering, The University of Cincinnati, Cincinnati, Ohio 2014-Present
Assistant Professor, Orthopaedic Surgery, University of Michigan—Ann Arbor, Ann Arbor, Michigan 2013- 2014
Assistant Professor, Biomedical Engineering,  University of Michigan—Ann Arbor, Ann Arbor, Michigan 2012-2014
Assistant Professor, Neurosurgery, University of Michigan—Ann Arbor, Ann Arbor, Michigan 2011-2014
Assistant Research Scientist, Biomedical Engineering, University of Michigan—Ann Arbor, Ann Arbor, Michigan 2007-2011
Research Assistant Professor, Neurosurgery, University of Michigan—Ann Arbor, Ann Arbor, Michigan 2007-2011
Research Investigator, Biomedical Engineering, University of Michigan—Ann Arbor, Ann Arbor, Michigan 2005-2007
Research Investigator, Neurosurgery, University of Michigan—Ann Arbor, Ann Arbor, Michigan 2004-2007


Honors & Awards

  • Whitecloud Basic Science Award Nominee, International Advanced Spine Techniques
2012
  • Young Scholar Professional Development Award, Society for Biomaterials, USA 
2003


Patents

Granted

03/2009: Integrated global layout and local microstructure topology optimization approach for spinal cage design and fabrication, US 7,509,183, Co-inventor, Submitted on 04/2004

07/2011: Biodegradable/bioresorbable tissue augmentation/reconstruction device, US 7,979,150, Co-inventor, Submitted on 12/2004

09/2012: Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration, US 8,275,594, Co-inventor, Submitted on 10/2007

Application in Process

Degradable cage for bone fusion, Co-inventor, Submitted on 02/2011

Method and device for repair of degenerative cartilage, Inventor, Submitted on 01/2009


Memberships in Professional Societies

2003-Present Member, Society for Biomaterials
2005-Present Member, International Society for Stem Cell Research
2006-Present Member, Orthopaedic Research Society
2008-Present Member, World Association for Chinese Biomedical Engineering
2010-Present Member, American Association for Cancer Research


Peer-Reviewed Journals and Publications

1. Hollister SJ, Lin CY, Lin CY, Schek RD, Taboas JM, Flanagan CL, Saito E, Williams JM, Das S, Wirtz T, Krebsbach PH: Design and fabrication of scaffolds for anatomic bone reconstruction. Med. J. Malaysia 59 Suppl B: 131-132, 2004. PM15468853

2. Lin CY, Hsiao CC, Chen PQ, Hollister SJ: Interbody fusion cage design using integrated global layout and local microstructure topology optimization. Spine 29(16): 1747-1754, 2004. PM15303018

3. Lin Chia-Ying, Lin Chen-Yu, Hollister Scott J: A new approach for designing biodegradable bone tissue augmentation devices by using degradation topology optimization Proceedings of Systemics, Cybernetics and Informatics 8: 112-118, 2004.

4. Huang CH, Liau JJ, Ho FY, Lin CY, Young TH, Cheng CK: Polyethylene failure of the patellar component in New Jersey low-contact stress total knee arthroplasties. The Journal of Arthroplasty 20(2): 202-8, 2005. PM15902859

5. Hollister SJ, Lin CY, Saito E, Lin CY, Schek RD, Taboas JM, Williams JM, Partee B, Flanagan CL, Diggs A, Wilke EN, Van Lenthe GH, Müller R, Wirtz T, Das S, Feinberg SE, Krebsbach PH: Engineering craniofacial scaffolds. Orthod Craniofac Res 8(3): 162-173, 2005. PM16022718

6. Lin CY, Schek RM, Mistry AS, Shi X, Mikos AG, Krebsbach PH, Hollister SJ: Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffolds. Tissue Eng. 11(9-10): 1589-1598, 2005. PM16259612

7. Hollister Scott J, Lin Chia-Ying, Lin Cheng-Yu: Image-based hierarchical analysis and design of tissue engineering scaffolds Mechanics of Biological Tissue 5: 503-515, 2006.

8. Lin CY, Wirtz T, LaMarca F, Hollister SJ: Structural and mechanical evaluations of a topology optimized titanium interbody fusion cage fabricated by selective laser melting process. J Biomed Mater Res A 83(2): 272-279, 2007. PM17415762

9. Zhang Huina, Lin Chia-Ying*: Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway. Spine 33(16): E525-31, 2008. PM18628692

10. Zhang H, Wang L, Park JB, Park P, Yang VC, Hollister SJ, La Marca F, Lin CY*: Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis Res. Ther. 11(6): R172, 2009. PM19912653

11. Wang L, Park P, Lin CY*: Characterization of stem cell attributes in human osteosarcoma cell lines. Cancer Biology & Therapy 8(6): 543-52, 2009. PM19242128

12. Zhang H, La Marca F, Hollister SJ, Goldstein SA, Lin CY*: Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture. J Neurosurg Spine 10(6): 522-530, 2009. PM19558284

13. Lin CY*, Kang H, Rouleau JP, Hollister SJ, Marca FL: Stress analysis of the interface between cervical vertebrae end plates and the Bryan, Prestige LP, and ProDisc-C cervical disc prostheses: an in vivo image-based finite element study. Spine 34(15): 1554-1560, 2009. PM19564765

14. Zhang H, Lin CY, Hollister SJ: The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds. Biomaterials 30(25): 4063-4069, 2009. PM19487019

15. Thawani JP, Wang AC, Than KD, Lin CY, La Marca F, Park P: Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery 66(2): 233-246, 2010. PM20042986

16. Kang Heesuk, Lin Chia-Ying, Hollister Scott J: Topology optimization of three dimensional tissue engineering scaffold architectures for prescribed bulk modulus and diffusivity Structural and Multidisciplinary Optimization 42: 633-644, 2010.

17. Kang H, Park P, La Marca F, Hollister SJ, Lin CY*: Analysis of load sharing on uncovertebral and facet joints at the C5-6 level with implantation of the Bryan, Prestige LP, or ProDisc-C cervical disc prosthesis: an in vivo image-based finite element study. Neurosurg Focus 28(6): E9, 2010. PM20568924

18. Lin CY*, Wang L, Than K, Marca FL, Park P: Cancer stem cell markers: what is their diagnostic value? Expert Opinion on Medical Diagnostics 4(6): 473-81, 2010. PM23496228

19. Zhang H, Migneco F, Lin CY, Hollister SJ: Chemically-conjugated bone morphogenetic protein-2 on three-dimensional polycaprolactone scaffolds stimulates osteogenic activity in bone marrow stromal cells. Tissue Eng Part A 16(11): 3441-3448, 2010. PM20560772

20. Wang L, Park P, Zhang H, La Marca F, Lin CY*: Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. Int. J. Cancer 128(2): 294-303, 2011. PM20309879

21. Wang L, Park P, Zhang H, La Marca F, Claeson A, Valdivia J, Lin CY*: BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. Cancer Biol. Ther. 11(5): 457-463, 2011. PM21178508

22. Zhang H, Yang S, Wang L, Park P, La Marca F, Hollister SJ, Lin CY*: Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: laboratory investigation. J Neurosurg Spine 15(4): 404-413, 2011. PM21721872

23. Than KD, Rahman SU, Vanaman MJ, Wang AC, Lin CY, Zhang H, La Marca F, Park P: Bone morphogenetic proteins and degenerative disk disease. Neurosurgery 70(4): 996-1002, 2012. PM22426045

24. Park JB, Zhang H, Lin CY, Chung CP, Byun Y, Park YS, Yang VC: Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors α. The Journal of Surgical Research 174(2): 278-83, 2012. PM21324392

25. Wang L, Rahman S, Lin CY, Valdivia J, Than K, La Marca F, Park P: A novel murine model of human renal cell carcinoma spinal metastasis. J Clin Neurosci 19(6): 881-883, 2012. PM22516545

26. Lin CY: Commentary Neurosurgery 71(1): 125, 2012. PM22893912

27. Wang Lin, Park Paul, La Marca Frank,Than Khoi, Rahman Shayan, Lin Chia-Ying*: Advancements in suppression of osteosarcoma tumorigenicity: a prospective look Journal of Cancer Therapy 3(4): 327-30, 2012.

28. Wang L, Park P, Zhang H, La Marca F, Claeson A, Than K, Rahman S, Lin CY*: BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. Int. J. Cancer 131(8): 1941-1950, 2012. PM22275155

29. Park YS, David AE, Park KM, Lin CY, Than KD, Lee K, Park JB, Jo I, Park KD, Yang VC: Controlled Release of Simvastatin from In situ Forming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells. The AAPS Journal 15(2): 367-76, 2012. PM23250670

30. Lin Wang, Paul Park, Frank La Marca, Khoi Than, Shayan Rahman, Chia-Ying Lin*: Bone formation induced by BMP-2 in human osteosarcoma cells Int. J. Oncology 43(4): 1095-102, 2013. PM23900689

31. Heesuk Kang, Scott J. Hollister, Frank La Marca, Paul Park, Chia-Ying Lin*: Porous biodegradable lumbar interbody fusion cage design and fabrication using integrated global-local topology optimization with laser sintering J Biomech Eng 135(10): 101013-8, 2013. PM23897113

32. Khoi D. Than, Shayan U. Rahman, Lin Wang, Adam Khan, Kwaku A. Kyere, Tracey T. Than, Yoshinari Miyata, Yoon-Shin Park, Frank La Marca, Hyungjin M. Kim, Huina Zhang, Paul Park, Chia-Ying Lin*: Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease The Spine Journal 14(6): 1017-1028, 2014.PM24291703


Submitted

1. Lin Wang, Paul Park, Frank La Marca, Khoi Than, and Chia-Ying Lin*: BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation Clinical Cancer Research. (Submitted)
 

Book Chapters

1. Hollister, SJ, Flanagan CL, Liao EE, Moffitt EN, Geong CG, Kemppainen JM, Saito E, Diggs A, Zhang H, Schek RM, Das S, Lin CY: Scaffolds with Designed Architecture: Effect on Scaffold Function and Tissue Regeneration. Translational Approaches in Tissue Engineering and Regenerative Medicine (Engineering in Medicine & Biology), Mao J, Vunjak-Novakovic G., Mikos A and Atala A Artech House, 2007.

2. Lin CY, Hollister SJ, Krebsbach, PH, La Marca F: New Adjunct in Spine Interbody Fusion: Designed Bioabsorbable Cage with Cell-Based Gene Therapy. Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics, and Engineering, Lewandrowski, K-U, Park, P., McLain, R.F., Kalfas, I.H., Yaszemski, M.J. and Trantolo D.J. Informa Healthcare, 2007.

3. Wong DY, Liao EE, Leverque JC, Brumblay H, Lin CY, La Marca F, Krebsbach PH, and Hollister SJ: Engineered Scaffold Architecture Influences Soft Tissue Regeneration. Biomaterials and Prototyping Applications in Medicine, Barolo, P. and Bidanda, B. Springer-Verlag US, 2008.

4. Hollister SJ, Lin CY, Kang H and Adachi T: Computational Design and Simulation of Tissue Engineering Scaffolds. Virtual and Rapid Prototyping in Medicine, Barolo, P. and Bidanda, B. Springer-Verlag US, 2008.

5. Hollister SJ, Flanagan CL, Moffitt EN, Lin CY, Schek RM, Cheung H, Das S, Feinberg SE, Krebsbach PH: Designed Biomaterial Scaffolds for Bone Regeneration. Biomaterials for Bone Regenerative Medicine, N.Sooraj Hussain and J. D. Santo Trans Tech Publishers, 2010.

6. Lin CY, Tobia W, La Marca, F, and Hollister SJ: Structural and Mechanical Evaluations of a Topology Optimized Titanium Interbody Fusion Cage Fabricated by Selective Laser Melting Process. Computer Aided Biomanufacturing, R. Narayan and P. Calver Wiley-VCH, 2011.


Abstracts

1. Lin, C.Y., Lin, C., and Hollister, S.J.: An Integrated Global Layout and Local Microstructure Topology Optimization for Spinal Cage Design and Fabrication, 29th annual meeting, Society for Biomaterials, Reno, NV, 2003.

2. Lin, C.Y., Hsiao, C.C., Chen, P.Q. and Hollister, S.J.: Mechanical Performance of Conventional Threaded Cage Designs and Interbody Fusion Cages Designed by Integrated Global Layout and Local Microstructure Topology Optimization, ASME Summer Bioengineering Conference, Key Biscayne, Miami, FL, 2003.

3. Lin, C.Y., Mistry, A.S., Shi, X., Mikos, A.G. and Hollister, S.J.: Degradation Properties and Potential Cell-Based Therapy Applications of Poly(Propylene Fumarate)/Beta-Tricalcium Phosphate Spine Interbody Fusion Cages with Topology Optimization Design, Northern Region Congress Asian Pacific Orthopaedic Association (APOA) in conjunction with 3rd Annual Meeting of Pacific Asian Society of Minimally Invasive Spine Surgery, Taipei, Taiwan, 2003.

4. Lin, C.Y., Schek, R.M., Mistry, A.S., Shih, X., Mikos, A.G., Krebsbach, P.H., and Hollister, S.J.: Functional Bone Tissue Engineering Using Ex Vivo Gene Therapy and Topology Optimized, Biodegradable Polymer Composite Scaffolds, 51st Meeting Orthopaedic Research Society, Washington D.C., 2005.

5. Lin, C.Y., Wirtz, T., and Hollister, S.J.: Structural and Mechanical Evaluations of A Topology Optimized Titanium Interbody Fusion Cage Fabricated By Selective Laser Melting, 51st Meeting Orthopaedic Research Society, Washington D.C., 2005.

6. La Marca, F., Ahmadinia, K., Brahma, B., Lin, C.Y. and Hollister, S.J.: Finite Element Analysis of an Adjacent Level Strain Determined from an In Vivo Spinal Fusion Model, AANS/CNS Spine Section, Phoenix, AZ, 2005.

7. Lin, C.Y., Nicholson, R, Brahma, B, La Marca, F. and Hollister, S.J.: Analysis of Multiple Level Spine Biomechanics after Charite Artificial Disc Arthorplasty by in Vivo Image-Based Finite Element Modeling, 52st Meeting Orthopaedic Research Society, Chicago, IL, 2006.

8. Zhang, H., and Lin, C.Y.: Simvastatin Stimulates Chondrogenic Phenotype of Rat Intervertebral Disc Cells Partially through BMP-2 Pathway, 53nd Meeting Orthopaedic Research Society, San Diego, CA, 2007.

9. Kang, H., Hollister, S.J., LaMarca, F., and Lin, C.Y.: In Situ Biodegradable Interbody Fusion Cage Design by the Integrated Global and Local Topology Optimization – An Example on Designing Yucatan Minipig Lumbar Interbody Fusion Cage for Large Animal Studies, 54th Meeting Orthopaedic Research Society, San Francisco, CA, 2008.

10. Kang, H., Rouleau, J.P., Hollister, S.J., LaMarca, F., and Lin, C.Y..: Stress Analysis on the Interface between the Cervical Vertebrae and the Endplates of Bryan, Prestige LP, and ProDisc-C Cervical Disc Prosthesis, 54th Meeting Orthopaedic Research Society, San Francisco, CA, 2008.

11. Zhang, H., and Lin, C.Y.: The Supplement of Cholesterol Facilitates Dominant Recovery in Pleiotropic Diminishing Intervertebral Disc Cell Viability After Simvastatin Treatement, 54th Meeting Orthopaedic Research Society, San Francisco, CA, 2008.

12. Wang, L., Park, P., and Lin, C.Y: Characterization of Stem Cell Attributes in Human Osteosarcoma Cell Lines, 55th Meeting Orthopaedic Research Society, Las Vegas, NV, 2009.

13. Kang, H., Hollister, S.J., LaMarca, F., Rouleau, J.P., Busuito, B, and Lin, C.Y.: Stress Analyses of Load Sharing on Facet and Uncovertebral Joints with Bryan, Prestige LP, and Prodisc-C Cervical Disc Prostheses, 55th Meeting Orthopaedic Research Society, Las Vegas, NV, 2009.

14. Zhang, H., LaMarca, F., Hollister, S.J., Goldstein, S.A., and Lin, C.Y.: The Controlled Intradiscal Release of Simvastatin Retards the Progression of Degeneration and Facilitates Autogeneous Repair at Rat Caudal Intervertebral Disc Injured by Needle Stab, 55th Meeting Orthopaedic Research Society, Las Vegas, NV, 2009.

15. Wang, L., Park, P., La Marca, F. and Lin, C.Y.: High Aldehyde DehydrogenaseActivity of Cancer Stem Cells in Human Osteosarcoma – An Extensive Study Using the OS99-1 Cell Line, 56th Meeting Orthopaedic Research Society, New Orleans, LA, 2010.

16. Kang, H., Hollister, S.J., Park, P., LaMarca, F., and Lin, C.Y.: Stress Analyses of Load In Situ Biodegradable Interbody Fusion Cage by the Intergrated Global and Local Topology Otimization and Fabrication Using the Selective Laser Sintering Technique, 56th Meeting Orthopaedic Research Society, New Orleans, LA, 2010.

17. Zhang, H., LaMarca, F., Hollister, S.J., Park, P., and Lin, C.Y.: Synergistic Inhibitions of Geranylgeranyltransferases by Simvastatin Participate in the Gene Up-Regulation of Bone Morphogenic Protein-2, 56th Meeting Orthopaedic Research Society, New Orleans, LA, 2010.

18. Wang, L., Park, P., Zhang, H., La Marca, F. and Lin, C.Y.: BMP-2 Inhibits the Tumorigenicity of Human Osteosarcoma Tumor-Initiating Cells, 101th Annual Meeting American Association of Cancer Research, Washington, D.C., 2011.

19. Wang, L., Park, P., Zhang, H., La Marca, F. and Lin, C.Y.: Characterization of Renal Tumor-Initiating Cells in Human Renal Carcinoma Cell Lines, 102nd Annual Meeting American Association of Cancer Research, Orlando, FL, 2011.

20. Rahman S, Zhang H, Than K, La Marca F, and Lin CY.: Developing intervertebral disc degeneration in rat caudal spine using needle puncture with and without rotational injury, 18th International Meeting on Advanced Spine Techniques, Copenhagen, Denmark, 2011.

21. Zhang, H., Yang, S., Wang, L., Park, P., La Marca, F., Hollister, S.J., and Lin, C.Y.: Time Course Investigation of Intervertebral Disc Degeneration Produced by Needle Stab Injury of the Rate Caudal Spine, 57th Meeting Orthopaedic Research Society, Long Beach, CA, 2011.

22. Park YS, David AE, Lin CY, Rahman S, Zhang H, Than K, Wang L, Park JB, Park KM, Park KD, Lee SJ, and Yang VC.: Controlled-release of simvastatin from hydrogels and its triggering of bone formation in MC3T3-E1 cells, The American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Washington D.C., 2011.

23. Than KD, Rahman SU, Wang L, Kyere KA, Than TT, Khan A, La Marca F, Park P, Zhang H, and Lin CY: Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease (Whitecloud Basic Science Award Nominee), The 19th International Meeting on Advanced Spine Techniques, Istanbul, Turkey, 2012.

24. Wang L, Park P, Than KD, Rahman SU, La Marca F, and Lin CY: BMP-2 inhibits tumor growth of human renal cell carcinoma by induction of bone formation, The 2012 AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Annual Meeting, Orlando, FL, 2012.

25. Than KD, Rahman SU, Kyere KA, Wang L, Than TT, Khan A, Park YS, Park KD, Yang VC, La Marca F, Park P, Zhang H, and Lin CY: Intradiscal injection of simvastatin for disc regeneration in a rat model of degenerative disc disease, The 2012 AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Annual Meeting, Orlando, FL, 2012.

26. Than KD, Rahman SU, Kyere KA, Wang L, Than TT, Khan A, Park YS, Park KD, Yang VC, La Marca F, Park P, Zhang H, and Lin CY: Intradiscal injection of simvastatin for disc regeneration in a rat model of degenerative disc disease, The 2012 American Association of Neurological Surgeons Annual Meeting, Miami, FL, 2012.

27. Than KD, Rahman SU, Wang L, Khan A, Kyere KA, La Marca F, Zhang H, Park P, and Lin CY: Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease, The 2012 Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 2012.

28. Than KD, Rahman SU, Wang L, Kyere KA, Than TT, Khan A, La Marca F, Park P, Zhang H, and Lin CY: Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease, The 2012 Lumbar Spine Research Society Annual Meeting, Chicago, IL, 2012.