Godby headed a research project for his first UC undergraduate cooperative experience in which he assessed the functional properties of murine (mouse) “asTF,” and compared these properties to human “asTF.” His results show that murine “asTF” is quite similar to human “asTF,” not only structurally but, more importantly, functionally. Like human “asTF,” murine “asTF” induces angiogenesis (the ability to induce the growth of new blood vessels from the existing ones).
Godby also found that both forms of “asTF” elicit comparable gene expression patterns in murine EC’s. He published his findings in “Molecular Medicine,” in a paper (http://www.ncbi.nlm.nih.gov/pubmed/22481268) titled “Non-Proteolytic Properties of Murine Alternatively Spliced Tissue Factor: Implications for Integrin-Mediated Signaling in Murine Models.” Godby’s results substantiate the use of murine models in future “asTF” studies.
Godby will complete his senior capstone studying the mechanical and molecular mechanisms of aortic valve disease at Children’s Hospital with Robert B. Hinton, MD, director of the Heart Institute BioRepository and UC Department of Pediatrics assistant professor. He wishes to pursue medical school upon graduation.
“As a future physician, I hope to use my engineering perspective in the clinic. Additionally, I want to leverage my skills gained during co-op work in both industry and research to serve as a liaison between the bench and bedside, facilitating an expedited integration of multiple disciplines to improve clinical outcomes and accelerate biomedical innovation,” Godby says.
Godby advises future research students to prepare themselves for the investment. He explains, “Research takes a lot of time and dedication, so be ready for that level of commitment. Also, take the time to carefully select an appropriate mentor. I’ve been blessed with incredible mentors who exemplify professionalism and have truly taken me under their wings, providing excellent foundations for an up-and-coming physician-scientist. Cincinnati is a research powerhouse rich with outstanding scientists, so find the one who’s right for you.”