CEAS Assistant Professor’s Paper Highlighted as a Key Scientific Article in Global Medical Discovery

Hyo-Jick Choi, PhD.

Hyo-Jick Choi, PhD.

A CEAS study funded by the Bill & Melinda Gates Foundation and partially by National Institutes of Health is garnering scientific acclaim.

The paper A Mechanistic Study on the Destabilization of Whole Inactivated Influenza Virus Vaccine in Gastric Environment about influenza oral vaccine is co-authored by Hyo-Jick Choi, PhD, an environmental engineering research assistant professor in the School of Energy, Environmental, Biological and Medical Engineering.

The project, designed by Dr. Hyo-Jick Choi and the University of Alberta’s Dr. Carlo Montemagno, was primarily carried out at the University of Cincinnati. The study, initiated by Dr. Choi, who proposed for the first time the idea of using stopped-flow light scattering analysis to characterize time-dependent morphological change of oral influenza vaccine, provides new insights into mechanisms of oral vaccine damage during digestion. UC researchers led the project through collaboration with Emory University Vaccine Center, Georgia State University, and University of Alberta.

The research, which seeks to examine destabilization mechanisms of whole inactivated influenza virus (WIV) vaccine in gastric environment as assessed by identifying critical factors affecting the stability of oral influenza vaccines, is highlighted by Global Medical Discovery as a key scientific article.

Read the article here