Regenerative Medicine

Headshot of Steven T Boyce

Steven T Boyce

Professor Emeritus, COM Surgery

422 Shriner's Burn Institute

513-872-6080

Headshot of Winston Whei Yang Kao

Winston Whei Yang Kao

Professor, COM Ophthalmology

5860 Care/Crawley

513-558-2802

The ultimate goal of our research project is to provide a better understanding of diseases which cause blindness, so that we can develop better treatment. We study the structure-function relationships of eye-specific genes which are vital for the maintenance of vision. Two research projects which are mutually supportive are: 1). Regulation of Cornea-specific K12 keratin gene expression, and 2). Corneal wound-healing. K12 keratin, exclusively expressed by corneal epithelial cells, is vital for normal corneal functions, and also plays an important role in corneal wound-healing. We are using the transgenic approach to examine the role of cytokines, receptors and/or other gene products in corneal wound-healing and development.
Headshot of Andrei B. Kogan

Andrei B. Kogan

Associate Professor, A&S Physics

422 Geology-Physics Building

513-556-0639

Headshot of Chia-Ying James Lin

Chia-Ying James Lin

Professor and Research Director of Orthopaedic Surgery, COM Orthopaedic Surgery

5452 Medical Sciences Building

513-558-8412

Headshot of Daria Narmoneva

Daria Narmoneva

Associate Professor, CEAS - Biomedical Eng

850 Engineering Research Cntr

513-556-3997

Chronic diabetic ulcers are the leading cause of non-traumatic limb amputations in the US and are a significant health care burden. To improve healing of chronic diabetic wounds, we created a unique microenvironment using a novel hydrogel (based on self-assembling peptide nanofibers) that mimics the native matrix in the wound and promotes healing. To activate unresponsive, diseased cells within the chronic wound, we have developed an electric field-based technology that uses high-frequency wireless electric fields stimulation to activate capillary cells and enhance blood vessel formation in the wound, which results in much faster healing. This technology has been successfully tested in the mouse and pig models, and is under active translational development in collaboration with UCRI and the UC Office for Entrepreneurial Affairs and Technology Commercialization.
Headshot of Liran   Oren

Liran Oren

Asst Professor - Research, COM Oto H&N B

6307B Medical Sciences Building

513-558-0073

Research focus:
Experimental studies of the human upper airway

Technical Expertise:
Experimental fluid dynamics
Aeroacoustics
Image processing 
 
Headshot of Phillip Owens

Phillip Owens

Assistant Professor Division of Cardiovascular Health and Disease, COM IM Cardiology Division

3925 Cardiovascular Rsrch Cntr

513-558-3428

Headshot of Sarah Katherine Pixley

Sarah Katherine Pixley

Associate Professor of Molecular & Cellular Physiology, COM Physiology Pixley Lab

4206A Medical Sciences Building

513-558-6086

 
Research in the Pixley lab has moved from a past emphasis on the neurogenesis and neuropharmacology of the olfactory system into more applied neural tissue repair work. Our current focus is on using novel biomaterials to promote neural tissue repair and regeneration. One of the most promising biomaterials is magnesium, primarily in metal form. Magnesium metal has properties that have increasingly attracted attention in recent years for use as a bioresorbable biomedical implant material. The most advanced uses are currently as bone fixation devices and as a cardiovascular stent material. Magnesium metal is strong initially, then very safely resorbs into the body. We are identifying novel ways to use magnesium metal to improve recovery of nervous tissues from injury damage, focusing first on repairing injury cuts in peripheral nerves in rats. We are also exploring the use of ionic magnesium for nervous tissue repair. Magnesium in ionic form is known to be neuroprotective and aids recovery of brain tissues after traumatic injury or stroke. Magnesium ions reduce secondary neuronal damage that occurs after the initial injury and reduce vasospasm that occurs in the brain after damage and is also damagine. Our collaborative group includes surgeons, neurobiologists, neuropathologists, and engineers from many categories. We are currently funded by an NSF grant that supports an Engineering Research Center dedicated to Revolutionizing Metallic Biomaterials (http://erc.ncat.edu/).  As a second focus, the lab is exploring the use of carbon nanotube (CNT) materials for nervous tissue repair. Expert engineering groups at UC produce novel forms of CNT materials, which are linear biomaterials with promise for promoting neuronal outgrowth and repair. Our initial work shows that neuronal stem cells migrate readily along CNT thread and complete differentiation. We are also using CNT materials to guide nervous tissue repair. 
Headshot of Xiaoyang Qi

Xiaoyang Qi

Professor of Medicine, Co-Division Chief for Basic Science Research, COM IM Hematology/Oncology Division

1314 Vontz Center

513-558-4025

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Jason Shearn

Interim Department Chair, CEAS - Biomedical Eng

501L Engineering Research Cntr

513-556-4175

Headshot of David W. Wendell

David W. Wendell

Assoc Professor, CEAS - Environmental Eng & Science

732 Engineering Research Cntr

513-556-2482

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Patrick Whitlock

Asst Professor - Clin Aff, COM Orthopaedic Surgery

Childrens Hospital Bldg R

513-636-4787