Regenerative Medicine

Headshot of Steven T Boyce

Steven T Boyce

Professor Emeritus , COM Surgery

422 Shriner's Burn Institute

513-872-6080

Education

Doctoral Degree, University of Colorado 1985 (Molecular, Cellular and Developmental Biology)

Bachelor's Degree, University of Colorado 1975 (Biological Sciences)

Postdoctoral Training, University of California - San Diego 1988

Research Support

Grant: #P021 Investigators:Boyce, Steven 09-30-2003 -09-30-2007 Food and Drug Administration Cultured Skin Substitutes for Closure of Burn Wounds Role:PI $1,226,854.00 Closed Level:Federal

Grant: #FDR000672-12-A0-S0-E0 Investigators:Boyce, Steven 09-30-2000 -09-29-2003 Food and Drug Administration Cultured Skin Substitutes for Closure of Burn Wounds Role:PI $904,633.00 Closed Level:Federal

Grant: #5-R01-GM-50509-12-A0-S0-E0 Investigators:Boyce, Steven 07-01-2002 -06-30-2007 National Institute of General Medical Sciences Mechanisms of Wound Healing with Cultured Human Skin Role:PI $1,454,969.00 Closed Level:Federal

Grant: #FDR000672-09-A0-S0-E0 Investigators:Boyce, Steven 09-30-1997 -09-29-2000 Food and Drug Administration Cultured Skin Substitutes for Closure of Burn Wounds Role:PI $897,236.00 Closed Level:Federal

Grant: #5-R01-GM-50509-08-A0-S0-E0 Investigators:Boyce, Steven 07-01-1998 -06-30-2002 National Institute of General Medical Sciences Mechanisms of Wound Healing with Cultured Human Skin Role:PI $1,144,178.00 Closed Level:Federal

Grant: #R01 GM079542 Investigators:Bailey, John; Boyce, Steven; Kagan, Richard; Supp, Dorothy; Warner, Petra; Yakuboff, Kevin 09-04-2007 -08-31-2012 National Institute of General Medical Sciences Somatic Stem C ells in Engineered Human Skin Role:PI $889,200.00 Active Level:Federal

Grant: #AFIRM Investigators:Boyce, Steven; Supp, Dorothy 03-10-2008 -06-30-2013 Department of the Army Medical Research and Materiel Command Armed Forces Institute For Regenerative Medicine (AFIRM) Role:PI $1,224,151.00 Active Level:Federal

Grant: #TECH 09-006 Investigators:Boyce, Steven; Supp, Dorothy 08-01-2008 -06-30-2012 Ohio Department of Development Engineered Skin Substitutes Containing Mesenchymal Stem Cells Role:PI $750,000.00 Active Level:State of Ohio

Grant: #3 R01 GM079542-03S1 Investigators:Boyce, Steven; Supp, Dorothy 09-30-2009 -08-31-2012 National Institute of General Medical Sciences R01 GM79542 Somatic Stem Cells in Engineered Human Skin Administrative Supplement Role:PI $246,973.00 Active Level:Federal

Grant: #WFUHS 441017 SR-07/W81XWH-13-2-0052 Investigators:Boyce, Steven 09-23-2013 -09-22-2017 Department of Defense Autologous Engineered Skin Substitutes With Pigment From Cultured Human Melanocytes (AFIRM II) Role:PI $390,225.00 Awarded Level:Federal

Grant: #R21 AR064341 08-01-2015 -07-31-2016 National Institute of Arthritis, Musculoskeletal and Skin Disease R21 'Regulated Morphogenesis of Human Sebaceous Glands' Role:PI $143,722.00 Awarded Level:Federal

Grant: #133118 / R21 AR064341 Investigators:Boyce, Steven 09-01-2014 -08-31-2016 National Institute of Arthritis, Musculoskeletal and Skin Disease Engineering of human sebaceous glands Role:PI $31,322.00 Active Level:Federal

Grant: #R21 AR064341 08-01-2015 -07-31-2016 National Institute of Arthritis, Musculoskeletal and Skin Disease R21 'Regulated Morphogenesis of Human Sebaceous Glands' Role:PI $143,722.00 Awarded Level:Federal

Grant: #URC Interdisciplinary Award AY2015-16 Investigators:Boyce, Steven; Supp, Dorothy; Zhang, Yuhang 05-01-2016 -04-30-2017 UC's University Research Council ENGINEERING HAIR FOLLICLE REGENERATION BY TARGETING DERMAL SHEATH CELLS Role:Collaborator $25,000.00 Active Level:Internal UC

Grant: #R21AR0173380 Investigators:Boyce, Steven; Supp, Dorothy; Zhang, Yuhang 04-01-2018 -03-31-2020 National Institute of Arthritis, Musculoskeletal and Skin Disease Reprogramming the dermal microenvironment to induce hair follicle neogenesis in engineered skin Role:Collaborator $211,043.00 Awarded Level:Federal

Publications
Published Abstracts

Boyce ST, J Pruszka, M Lockhard, M Estes, M Rust, DM supp and RJ Kagan (2010. )Formation of vascular channels in engineered skin substitutes .[Abstracy]Annual report of the Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting,

Boyce ST, R Zimmerman, VB Swope, DM Supp and RJ Kagan (2010. )Regulation of pigmentation in engineered skin substitutes .[Abstracy]Annual report of the Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting,

Supp DM, JM Klingenberg, KL McFarland, K Glaser, ST Boyce, K Bailey, K Yakuboff, P Warner, and RJ Kagan (2010. )Engineered skin as an organotypic model for keloid scarring .[Abstracy]J Burn Care Res, 31 (2 ),S53

Boyce ST, AP Supp, RK Rice, VB Swope, DM Supp, and RJ Kagan (2010. )Pulse-chase assessment of label-retaining keratinocytes in engineered skin substitutes after grafting to athymic mice .[Abstracy]J Burn Care Res , 31 (2 ),S54

McFarland KL, K Glaser, JM Hahn, ST Boyce, and DM Supp (2011. )Culture medium formulation and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. J Burn Care Res, 32 (2 ),S177

Boyce ST, RL Zimmerman, KA Lynch, DM Supp, and RJ Kagan (2011. )Regulation of skin pigmentation in engineered skin substitutes .[Abstracy]Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; ,

Boyce ST, KA Lynch, RL Zimmerman, DM Supp, and RJ Kagan (2011. )Flow cytometry for regulation of melanocyte density in engineered skin substitutes. .[Abstracy]Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; ,

Boyce ST, RL Zimmerman, DM Supp, and RJ Kagan (2011. )Tumorigenicity testing of human melanocytes for engineered skin substitutes. .[Abstracy]Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; ,

Glaser K, JM Hahn, KL McFarland, ST Boyce, and DM Supp (2011. )Abnormal responses of keloid tissue to wounding identified using an in vitro model system. Wound Repair Regen , 19 (2 ),A24

Sriwiriyanont P, EA Maier, KA Lynch, DM Supp, and ST Boyce (2011. )Dermal papilla cells promote trichogenesis in engineered skin substitutes. .[Abstracy]J Invest Dermatol , 131 ,S79

Chavez-Munoz C, R Hartwell, RB Jalili, ST Boyce, and A Ghahary (2012. )Functioning of IDO-expressing engineered skin composite in a fibrotic animal model. J Burn Care Res , 33 (2 ),S64

Rieman MT, A Neeley, ST Boyce, and RJ Kagan (2012. )Amish Burn Wound Ointment (ABWO) and burdock leaf dressings: assessments of antimicrobial & cytotoxic activities. J Burn Care Res, 33 (2 ),S142

Supp DM, JM Hahn, K Glaser, KL McFarland, and ST Boyce (2012. )Distinct phenotypes of deep vs. superficial keloid fibroblasts in keloid skin substitutes transplanted to athymic mice. J Burn Care Res, 33 (2 ),S64

Boyce ST, KA Lynch, RL Zimmerman, and DM Supp (2012. )Transition to Technology Readiness Level 5 of engineered skin substitutes with pigment: scientific, regulatory and institutional considerations. .[Abstracy]Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; St. Pete’s Beach, FL.,

Boyce ST, MT Rieman, and RJ Kagan (2012. )Reduced mortality in pediatric burn patients treated with autologous cultured skin substitutes during an FDA Integrity Hold. .[Abstracy]Proceedings of an FDA Public Workshop on Medical Countermeasures for a Burn Mass Casualty Incident. ,

Supp DM, JM Hahn, K Glaser, KL McFarland, ST Boyce, BJ Aronow, and RJ Kagan (2013. )Keloid keratinocytes altered expression of genes involved in differentiation, adhesion, and epithelial-mesenchymal transition. .[Abstracy]J Burn Care Res, 34 (2 ),S94

Boyce ST, C Lloyd, R Zimmerman, and DM Supp (2015. )Regulation of pigmentation in engineered skin substitutes. .[Abstracy]Annual report of the Armed Forces Institute for Regenerative Medicine (AFIRM), Investigators Meeting; Bethesda, MD.,

207. Boyce ST, Simpson PS, Rieman MT, Warner P, Yakuboff KP, Bailey JK, Nelson JK, Fowler LA, Kagan RJ (2015. )Autologous engineered skin substitutes reduce mortality and harvesting of skin graft donor sites for closure of extensive, full-thickness burns. J Burn Care Res , 36 (3 ),S107

Boyce ST, CM Lloyd, RL Zimmerman, and DM Supp (2015. )Restoration of skin color by human melanocytes in engineered skin substitutes grafted to full-thickness wounds. .[Abstracy]J Burn Care Res, 36 (3 ),S83

Supp DM, JM Hahn, ST Boyce, and KL McFarland (2015. )Involvement of TGF-β1-mediated epithelial-mesenchymal transition in keloid scarring. .[Abstracy]J Burn Care Res, 36 (3 ),S84

Peer Reviewed Publications

Powell,H.M.; Supp,D.M.; Boyce,S.T. (2008. )Influence of electrospun collagen on wound contraction of engineered skin substitutes .Biomaterials, ,29 (7 ),834 -843

2008- Biomaterials

Kalyanaraman,B.; Boyce,S. (2007. )Assessment of an automated bioreactor to propagate and harvest keratinocytes for fabrication of engineered skin substitutes .Tissue Engineering, ,13 (5 ),983 -993

2007- TE

Powell,H.M.; Boyce,S.T. (2007. )Wound closure with edc cross-linked cultured skin substitutes grafted to athymic mice .Biomaterials, ,28 (6 ),1084 -1092

2007- Biomaterials

Boyce,S.T.; Kagan,R.J.; Greenhalgh,D.G.; Warner,P.; Yakuboff,K.P.; Palmieri,T.; Warden,G.D. (2006. )Cultured skin substitutes reduce requirements for harvesting of skin autograft for closure of excised, full-thickness burns .Journal of Trauma - Injury, Infection and Critical Care, ,60 (4 ),821 -829

2006- J Trauma

Powell,H.M.; Boyce,S.T. (2006. )EDC cross-linking improves skin substitute strength and stability .Biomaterials, ,27 (34 ),5821 -5827

2006- Powell

Barai,N.D.; Supp,A.P.; Kasting,G.B.; Visscher,M.O.; Boyce,S.T. (2006. )Improvement of epidermal barrier properties in cultured skin substitutes after grafting onto athymic mice .Skin Pharmacology and Physiology, ,20 (1 ),21 -28

2005- Skin Pharm

Swope,V.B.; Supp,A.P.; Schwemberger,S.; Babcock,G.; Boyce,S. (2006. )Increased expression of integrins and decreased apoptosis correlate with increased melanocyte retention in cultured skin substitutes .Pigment Cell Research, ,19 (5 ),424 -433

2006- PCR

Smiley,A.K.; Klingenberg,J.M.; Boyce,S.T.; Supp,D.M. (2006. )Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting .Burns, ,32 (2 ),135 -138

2006- Burns

Boyce,S.T.; Anderson,B.A.; Rodriguez-Rilo,H.L. (2006. )Quantitative assay for quality assurance of human cells for clinical transplantation .Cell Transplantation, ,15 (2 ),169 -174

2006- Cell Transplantation

Swope,V.B.; Boyce,S.T. (2005. )Differential expression of matrix metalloproteinase-1 in vitro corresponds to tissue morphogenesis and quality assurance of cultured skin substitutes .Journal of Surgical Research, ,128 (1 ),79 -86

2005- JSR

Supp,A.P.; Neely,A.N.; Supp,D.M.; Warden,G.D.; Boyce,S.T. (2005. )Evaluation of cytotoxicity and antimicrobial activity of acticoat® burn dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice .Journal of Burn Care and Rehabilitation, ,26 (3 ),238 -246

2005- J Burn Care Rehabil

Smiley,A.K.; Klingenberg,J.M.; Aronow,B.J.; Boyce,S.T.; Kitzmiller,W.J.; Supp,D.M. (2005. )Microarray analysis of gene expression in cultured skin substitutes compared with native human skin .Journal of Investigative Dermatology, ,125 (6 ),1286 -1301

2005- JID

Passaretti,D.; Billmire,D.; Kagan,R.; Corcoran,J.; Boyce,S. (2004. )Autologous cultured skin substitutes conserve donor autograft in elective treatment of congenital giant melanocytic nevus .Plastic and Reconstructive Surgery, ,114 (6 ),1523 -1528

2004- Plast Reconstr Surg

Supp,D.M.; Karpinski,A.C.; Boyce,S.T. (2004. )Expression of human β-defensins hbd-1, hbd-2, and hbd-3 in cultured keratinocytes and skin substitutes .Burns, ,30 (7 ),643 -648

2004- Burns

Supp,D.M.; Karpinski,A.C.; Boyce,S.T. (2004. )Vascular endothelial growth factor overexpression increases vascularization by murine but not human endothelial cells in cultured skin substitutes grafted to athymic mice .Journal of Burn Care and Rehabilitation, ,25 (4 ),337 -345

2004- J Burn Care Rehabil

Holder,I.A.; Durkee,P.; Supp,A.P.; Boyce,S.T. (2003. )Assessment of a silver-coated barrier dressing for potential use with skin grafts on excised burns .Burns, ,29 (5 ),445 -448

2003- Burns

Boyce,S.T.; Kagan,R.J.; Yakuboff,K.P.; Meyer,N.A.; Rieman,M.T.; Greenhalgh,D.G.; Warden,G.D. (2002. )Cultured skin substitutes reduce donor skin harvesting for closure of excised, full-thickness burns .Annals of Surgery, ,235 (2 ),269 -279

2002- Ann Surg

Supp,D.M.; Wilson-Landy,K.; Boyce,S.T. (2002. )Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice .FASEB Journal, ,16 (8 ),797 -804

2002- FASEB

Supp,D.M.; Boyce,S.T. (2002. )Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes .Journal of Burn Care and Rehabilitation, ,23 (1 ),10 -20

2002- JBCR

Swope,V.B.; Supp,A.P.; Boyce,S.T. (2002. )Regulation of cutaneous pigmentation by titration of human melanocytes in cultured skin substitutes grafted to athymic mice .Wound Repair and Regeneration, ,10 (6 ),378 -386

2002- WRR

Boyce,S.T.; Supp,A.P.; Swope,V.B.; Warden,G.D. (2002. )Vitamin c regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes .Journal of Investigative Dermatology, ,118 (4 ),565 -572

2002- JID

Swope,V.B.; Supp,A.P.; Greenhalgh,D.G.; Warden,G.D.; Boyce,S.T. (2001. )Expression of insulin-like growth factor i by cultured skin substitutes does not replace the physiologic requirement for insulin in vitro .Journal of Investigative Dermatology, ,116 (5 ),650 -657

2001- J Invest Dermatol

Robb,E.C.; Bechmann,N.; Plessinger,R.T.; Boyce,S.T.; Warden,G.D.; Kagan,R.J. (2001. )Storage media and temperature maintain normal anatomy of cadaveric human skin for transplantation to full-thickness skin wounds .Journal of Burn Care and Rehabilitation, ,22 (6 ),393 -396

2001- JBCR-Robb

Boyce,S.T.; Supp,A.P.; Wickett,R.R.; Hoath,S.B.; Warden,G.D. (2000. )Assessment with the dermal torque meter of skin pliability after treatment of burns with cultured skin substitutes .Journal of Burn Care and Rehabilitation, ,21 (1 I ),55 -63

2000- J Burn Care Rehabil

Supp,D.M.; Supp,A.P.; Bell,S.M.; Boyce,S.T. (2000. )Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor .Journal of Investigative Dermatology, ,114 (1 ),5 -13

2000- J Invest Dermatol

Supp,D.M.; Bell,S.M.; Morgan,J.R.; Boyce,S.T. (2000. )Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet-derived growth factor-a .Wound Repair and Regeneration, ,8 (1 ),26 -35

2000- Wound Repair Regen

Holder,I.A.; Boyce,S.T. (1999. )Assessment of the potential for microbial resistance to topical use of multiple antimicrobial agents .Wound Repair and Regeneration, ,7 (4 ),238 -243

1999- Wound Repair Regen

Supp,A.P.; Wickett,R.R.; Swope,V.B.; Harriger,M.D.; Hoath,S.B.; Boyce,S.T. (1999. )Incubation of cultured skin substitutes in reduced humidity promotes cornification in vitro and stable engraftment in athymic mice .Wound Repair and Regeneration, ,7 (4 ),226 -237

1999- Wound Repair Regen

Le Poole,I.C.; Boyce,S.T. (1999. )Keratinocytes suppress transforming growth factor-β1 expression by fibroblasts in cultured skin substitutes .British Journal of Dermatology, ,140 (3 ),409 -416

1999- British J Dermatol

Boyce,S.T.; Supp,A.P.; Swope,V.B.; Warden,G.D. (1999. )Topical sulfamylon reduces engraftment of cultured skin substitutes on athymic mice .Journal of Burn Care and Rehabilitation, ,20 (1 I ),33 -36

1999- J Burn Care Rehabil

Can,G.; Abdel-Malek,Z.; Porter-Gill,P.A.; Gill,P.; Boyce,S.; Grabowski,G.A.; Nordlund,J.; Farooqui,J. (1998. )Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture .Journal of Investigative Dermatology, ,111 (3 ),485 -491

1998- J Invest Dermatol

Boyce,S.T.; Harriger,M.D.; Supp,A.P.; Warden,G.D.; Holder,I.A. (1997. )Effective management of microbial contamination in cultured skin substitutes after grafting to athymic mice .Wound Repair and Regeneration, ,5 (2 ),191 -197

1997- Wound Repair Regen

Vicanova ,J.; Ponec, M.; Weerheim, A.; Swope,V.; Westbrook,M.; Harriger,D.; Boyce,S. (1997. )Epidermal lipid metabolism of cultured skin substitutes during healing of full-thickness wounds in athymic mice .Wound Repair and Regeneration, ,5 (4 ),329 -338

1997- Wound Rep Regen

Harriger,M.D.; Supp,A.P.; Warden,G.D.; Boyce,S.T. (1997. )Glutaraldehyde crosslinking of collagen substrates inhibits degradation in skin substitutes grafted to athymic mice .Journal of Biomedical Materials Research, ,35 (2 ),137 -145

1997- J Biomed Mater Res

Swope,V.B.; Supp,A.P.; Cornelius,J.R.; Babcock,G.F.; Boyce,S.T. (1997. )Regulation of pigmentation in cultured skin substitutes by cytometric sorting of melanocytes and keratinocytes .Journal of Investigative Dermatology, ,109 (3 ),289 -295

1997- JID

Gennari,R.; Alexander,J.W.; Boyce,S.T.; Lilly,N.; Babcock,G.F.; Cornaggia,M. (1996. )Effects of the angiotensin converting enzyme inhibitor enalapril on bacterial translocation after thermal injury and bacterial challenge .Shock, ,6 (2 ),95 -100

1996- Shock

Goretsky,M.J.; Harriger,M.D.; Supp,A.P.; Greenhalgh,D.G.; Boyce,S.T. (1996. )Expression of interleukin-1α, interleukin-6, and basic fibroblast growth factor by cultured skin substitutes before and after grafting to full-thickness wounds in athymic mice .Journal of Trauma - Injury, Infection and Critical Care, ,40 (6 ),894 -899

1996- J Trauma

Holder,I.A.; Boyce,S.T. (1996. )Formulation of 'idealized' topical antimicrobial mixtures for use with cultured skin grafts .Journal of Antimicrobial Chemotherapy, ,38 (3 ),457 -463

1996- J Antimicrobial Chemotherapy

Boyce,S.T.; Supp,A.P.; Harriger,M.D.; Pickens,W.L.; Wickett,R.R.; Hoath,S.B. (1996. )Surface electrical capacitance as a no index of epidermal barrier in cultured skin substitutes in athymic mice .Journal of Investigative Dermatology, ,107 (1 ),82 -87

1996- J Invest Dermatol- Boyce

Boyce,S.T.; Goretsky,M.J.; Greenhalgh,D.G.; Kagan,R.J.; Rieman,M.T.; Warden,G.D. (1995. )Comparative assessment of cultured skin substitutes and native skin autograft for treatment of full-thickness burns .Annals of Surgery, ,222 (6 ),743 -752

1995- Annals of Surgery

Boyce,S.T.; Warden,G.D.; Holder,I.A. (1995. )Cytotoxicity testing of topical antimicrobial agents on human keratinocytes and fibroblasts for cultured skin grafts .Journal of Burn Care and Rehabilitation, ,16 (2 I ),97 -103

1995- J Burn Care Rehabil

Farooqui,J.Z.; Robb,E.; Boyce,S.T.; Warden,G.D.; Nordlund,J.J. (1995. )Isolation of a unique melanogenic inhibitor from human skin xenografts: initial in vitro and in vivo characterization .Journal of Investigative Dermatology, ,104 (5 ),739 -743

1995- J Invest Dermatol- Farooqui

Abdel-Malek,Z.; Swope,V.B.; Suzuki,I.; Akcali,C.; Harriger,M.D.; Boyce,S.T.; Urabe,K.; Hearing,V.J. (1995. )Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides .Proceedings of the National Academy of Sciences of the United States of America, ,92 (5 ),1789 -1793

1995- PNAS

Boyce,S.T.; Warden,G.D.; Holder,I.A. (1995. )Noncytotoxic combinations of topical antimicrobial agents for use with cultured skin substitutes .Antimicrobial Agents and Chemotherapy, ,39 (6 ),1324 -1328

1995- Antimicrobial Agents and Chemotherapy

Harriger,M.D.; Warden,G.D.; Greenhalgh,D.G.; Kagan,R.J.; Boyce,S.T. (1995. )Pigmentation and microanatomy of skin regenerated from composite grafts of cultured cells and biopolymers applied to full-thickness burn wounds .Transplantation, ,59 (5 ),702 -707

1995- Transplantation

Boyce,S.T.; Supp,A.P.; Harriger,M.D.; Greenhalgh,D.G.; Warden,G.D. (1995. )Topical nutrients promote engraftment and inhibit wound contraction of cultured skin substitutes in athymic mice .Journal of Investigative Dermatology, ,104 (3 ),345 -349

1995- J Invest Dermatol

Holder,I.A.; Boyce,S.T. (1994. )Agar well diffusion assay testing of bacterial susceptibility to various antimicrobials in concentrations non-toxic for human cells in culture .Burns, ,20 (5 ),426 -429

1994- Burns

Boyce,S.T.; Holder,I.A.; Supp,A.P.; Warden,G.D.; Greenhalgh,D.G. (1994. )Delivery and activity of antimicrobial drugs released from human fibrin sealant .Journal of Burn Care and Rehabilitation, ,15 (3 ),251 -255

1994- J Burn Care Rehabil

Boyce,S.T.; Supp,A.P.; Warden,G.D.; Holder,I.A. (1993. )Attachment of an aminoglycoside, amikacin, to implantable collagen for local delivery in wounds .Antimicrobial Agents and Chemotherapy, ,37 (9 ),1890 -1895

1993- Antimicrobial Agents and chemotherapy

Boyce,S.T.; Williams,M.L. (1993. )Lipid supplemented medium induces lamellar bodies and precursors of barrier lipids in cultured analogues of human skin .Journal of Investigative Dermatology, ,101 (2 ),180 -184

1993- J Invest Dermaol

Boyce,S.T.; Medrano,E.E.; Abdel-Malek,Z.; Supp,A.P.; Dodick,J.M.; Nordlund,J.J.; Warden,G.D. (1993. )Pigmentation and inhibition of wound contraction by cultured skin substitutes with adult melanocytes after transplantation to athymic mice .Journal of Investigative Dermatology, ,100 (4 ),360 -365

1993- J Invest Dermaol

Hoath,S.B.; Tanaka,R.; Boyce,S.T. (1993. )Stratum corneum formation in the perinatal rat .Journal of Investigative Dermatology, ,100 (4 ),400 -406

1993- J Invest Dermaol

Boyce,S.T.; Holder,I.A. (1993. )Selection of topical antimicrobial agents for cultured skin for burns by combined assessment of cellular cytotoxicity and antimicrobial activity .Plastic and Reconstructive Surgery, ,92 (3 ),493 -500

1993- Plastic and Reconstrucive Surgery

Boyce,S.T.; Greenhalgh,D.G.; Kagan,R.J.; Housinger,T.; Sorrell,J.M.; Childress,C.P.; Rieman,M.; Warden,G.D. (1993. )Skin anatomy and antigen expression after burn wound closure with composite grafts of cultured skin cells and biopolymers .Plastic and Reconstructive Surgery, ,91 (4 ),632 -641

1993- Plast Reconstr Surg

Boyce,S.T.; Foreman,T.J.; Furmanski,P.; Hansbrough,J.F. (1992. )Absence of tumorigenicity in athymic mice by normal human epidermal keratinocytes after culture in serum-free medium .Cancer Letters, ,62 (2 ),141 -147

1992- Cancer Letters

Kuroiwa,K.; Nelson,J.L.; Boyce,S.T.; Alexander,J.W.; Ogle,C.K.; Inoue,S. (1991. )Metabolic and immune effect of vitamin e supplementation after burn .Journal of Parenteral and Enteral Nutrition, ,15 (1 ),22 -26

1991- J Parent Ent Nutri

Cooper,M.L.; Spielvogel,R.L.; Hanbrough,J.F.; Boyce,S.T.; Frank,D.H. (1991. )Reconstitution of the histologic characteristics of a giant congenital nevomelanocytic nevus employing the athymic mouse and a cultured skin substitute .Journal of Investigative Dermatology, ,97 (4 ),649 -658

1991- J Invest Dermatol- Cooper

Stompro,B.E.; Hansbrough,J.F.; Boyce,S.T. (1989. )Attachment of peptide growth factors to implantable collagen .Journal of Surgical Research, ,46 (5 ),413 -421

1989- J Surg Res

Hansbrough,J.F.; Boyce,S.T.; Cooper,M.L.; Foreman,T.J. (1989. )Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate .Journal of the American Medical Association, ,262 (15 ),2125 -2130

1989- JAMA-Handbrough

Boyce,S.T.; Glafkides,M.C.; Foreman,T.J.; Hansbrough,J.F. (1988. )Reduced wound contraction after grafting of full-thickness burns with a collagen and chondroitin-6-sulfate (gag) dermal skin substitute and coverage with biobrane .Journal of Burn Care and Rehabilitation, ,9 (4 ),364 -370

1988- J Burn Care adn Rehab

Boyce,S.T.; Ham,R.G. (1983. )Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture .Journal of Investigative Dermatology, ,81 (1 Suppl. ),33S -40S

1983-J Invest Dermatol

Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T (2010. )Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin.Tissue engineering. Part A, ,16 (3 ),1083-92

2010- TE-A

Armour, Alexis D; Powell, Heather M; Boyce, Steven T (2008. )Fluorescein diacetate for determination of cell viability in tissue-engineered skin.Tissue engineering. Part C, Methods, ,14 (1 ),89-96

2008- TE- Armour

Rieman, Mary T; Neely, Alice N; Boyce, Steven T; Kossenjans, William J; Durkee, Paula J; Zembrodt, Jacquelyn M; Puthoff, Barbara K; Kagan, Richard J (2014. )Amish burn ointment and burdock leaf dressings: assessments of antimicrobial and cytotoxic activities.Journal of burn care & research : official publication of the American Burn Association, ,35 (4 ),e217-23

2014- JMCR

Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F (2013. )Concerns over interspecies transcriptional comparisons in mice and humans after trauma.Proceedings of the National Academy of Sciences of the United States of America, ,110 (36 ),E3370

2013- PNAS

Kalyanaraman, Balaji; Boyce, Steven T (2009. )Wound healing on athymic mice with engineered skin substitutes fabricated with keratinocytes harvested from an automated bioreactor.The Journal of surgical research, ,152 (2 ),296-302

2009- JSR

Wikner, N E; Huff, J C; Norris, D A; Boyce, S T; Cary, M; Kissinger, M; Weston, W L (1986. )Study of HLA-DR synthesis in cultured human keratinocytes. The Journal of investigative dermatology, ,87 (5 ),559-64

1985- J Invest Dermatol- Wikner

LeFeber, W P; Norris, D A; Ryan, S R; Huff, J C; Lee, L A; Kubo, M; Boyce, S T; Kotzin, B L; Weston, W L (1984. )Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes.The Journal of clinical investigation, ,74 (4 ),1545-51

1984- J Clin Invest

Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M (2014. )Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes.Cell transplantation, ,

2014- Cell Transplantation

Boyce, S T; Hansbrough, J F (1988. )Biologic attachment, growth, and differentiation of cultured human epidermal keratinocytes on a graftable collagen and chondroitin-6-sulfate substrate. Surgery, ,103 (4 ),421-31

1988-Surgery

Boyce, S T; Kagan, R J; Meyer, N A; Yakuboff, K P; Warden, G D (1999. )The 1999 clinical research award. Cultured skin substitutes combined with Integra Artificial Skin to replace native skin autograft and allograft for the closure of excised full-thickness burns. The Journal of burn care & rehabilitation, ,20 (6 ),453-61

1999- J Burn Care Rehabil

Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T (2013. )Characterization of hair follicle development in engineered skin substitutes.PloS one, ,8 (6 ),e65664

2013- PLos-ONE

Harriger, M D; Supp, A P; Swope, V B; Boyce, S T (1997. )Reduced engraftment and wound closure of cryopreserved cultured skin substitutes grafted to athymic mice.Cryobiology, ,35 (2 ),132-42

1997- Cryobiology

Boyce, S.T.; Simpson, P.S.; and Kagan,R.J. (2008. )Survival of burns involving 90% of the total body surface area after treatment with autologous engineered skin substitutes. Proc 26th Army Science Conference; http://www.asc2008.com/manuscripts/L/LO-02.pdf, ,

2008- PASC

Goretsky, M J; Supp, A P; Greenhalgh, D G; Warden, G D; Boyce, S T (1995. )Surface electrical capacitance as an index of epidermal barrier properties of composite skin substitutes and skin autografts.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,3 (4 ),419-25

1995- Wound Repair Regen

Forouzandeh, F.; Jalili, R.B.; Boyce, S.T.; Supp, D.M.; and Ghahary, A. (2010. )Local expression of indoleamine 2, 3-dioxygenase (IDO) suppresses T-cell mediated rejection of an engineered bilayered skin substitute. Wound Repair Regen, ,18 (6 ),614-623

2010- WRR

Lloyd, C.M.; Besse, J.A.; and Boyce, S.T. (2014. )Controlled rate freezing to regulate the structure of collagen-glycosaminoglycan scaffolds in engineered skin substitutes.J Biomed Mater Res- Part B, ,

2014- JBMR-B

Boyce, S.T.; Bailey, J.K.; Warner, P.; Yakuboff, K.P.; Simpson, P.S.; Rieman, M.T.; and Kagan, R.J. (2015. )Reduced mortality and donor site harvesting after treatment of deep, extensive burns with autologous engineered skin substitutes. Submitted .

Powell, Heather M; Armour, Alexis D; Boyce, Steven T (2011. )Fluorescein diacetate for determination of cell viability in 3D fibroblast-collagen-GAG constructs.Methods in molecular biology (Clifton, N.J.), ,740 ,115-26

2011- Method Mol Med

Boyce, S.T.; Zimmerman, R.L.; Lloyd, C.M.; Supp, D.M. (2015. )Restoration of skin color by human melanocytes in engineered skin substitutes grafted to full-thickness wounds. J Invest Dermatol, ,

Boyce, S.T.; Lloyd, C.M.; and Supp, D.M. (2015. )Tyrosinase inhibitors for regulation of cellular viability and melanin synthesis in cultured human melanocytes for clinical transplantation .J Invest Dermatol, ,

Boyce, S.T.; Lloyd, C.M.; and Supp, D.M. (2015. )Induction of VEGF expression in engineered skin substitutes by hypobaric oxygen .Tissue Engineering, ,

Boyce, S.T.; Supp, A.P.; Reed, M.A.; Kagan, R.J. (2015. )Quantitative assessment of skin pliability after treatment of full thickness burns with cultured skin substitutes and split-thickness autografts combined with Integra Artifical Skin or cadaveric allograft .J Burn Care Res, ,

Krueger, G G; Morgan, J R; Jorgensen, C M; Schmidt, L; Li, H L; Kwan, M K; Boyce, S T; Wiley, H S; Kaplan, J; Petersen, M J (1994. )Genetically modified skin to treat disease: potential and limitations. The Journal of investigative dermatology, ,103 (5 Suppl ),76S-84S

1994- J Invest Dermatol

Chavez-Munoz, Claudia; Hartwell, Ryan; Jalili, Reza B; Carr, Matthew; Kilani, Ruhangiz T; Jafarnejad, Seyed Mehdi; Rahmani-Neishabour, Elham; Forouzandeh, Farshad; Boyce, Steven T; Ghahary, Aziz (2012. )Application of an indoleamine 2,3-dioxygenase-expressing skin substitute improves scar formation in a fibrotic animal model.The Journal of investigative dermatology, ,132 (5 ),1501-5

2012- JID

Kinneberg, Kirsten R C; Nirmalanandhan, Victor S; Juncosa-Melvin, Natalia; Powell, Heather M; Boyce, Steven T; Shearn, Jason T; Butler, David L (2010. )Chondroitin-6-sulfate incorporation and mechanical stimulation increase MSC-collagen sponge construct stiffness.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, ,28 (8 ),1092-9

2010- J Ortho Res

Powell, Heather M; Boyce, Steven T (2009. )Engineered human skin fabricated using electrospun collagen-PCL blends: morphogenesis and mechanical properties.Tissue engineering. Part A, ,15 (8 ),2177-87

Wang, Q; Meyer, T A; Boyce, S T; Wang, J J; Sun, X; Tiao, G; Fischer, J E; Hasselgren, P O (1998. )Endotoxemia in mice stimulates production of complement C3 and serum amyloid A in mucosa of small intestine .The American journal of physiology, ,275 (5 Pt 2 ),R1584-92

Boyce, S T; Foreman, T J; English, K B; Stayner, N; Cooper, M L; Sakabu, S; Hansbrough, J F (1991. )Skin wound closure in athymic mice with cultured human cells, biopolymers, and growth factors. Surgery, ,110 (5 ),866-76

1991- Surgery

Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T (2012. )Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells.Experimental dermatology, ,21 (10 ),783-5

2012- Exp Dermatol

Supp, D.M.; Glaser, K.; Hahn, J.M.; McFarland, K.L.; Boyce, S.T. (2012. )Abnormal responses of keloid tissue to wounding identified using an in vitro model system .Eplasty, ,12 ,184-187

2012- ePlasty

McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M (2011. )Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts.Journal of burn care & research : official publication of the American Burn Association, ,32 (4 ),498-508

2011- JBCR

Alexander, J W; Boyce, S T; Babcock, G F; Gianotti, L; Peck, M D; Dunn, D L; Pyles, T; Childress, C P; Ash, S K (1990. )The process of microbial translocation. Annals of surgery, ,212 (4 ),496-510; discussion

1990- Ann Surg

Cooper, M L; Boyce, S T; Hansbrough, J F; Foreman, T J; Frank, D H (1990. )Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents. The Journal of surgical research, ,48 (3 ),190-5

1990- J Surg. Res

Warner, P.; Warden, G.D.; Yakuboff,K.P.; Boyce, S.T.; and Kagan, R.J. (2008. )An 18-year experience in the management of congenital nevomelanocytic nevi .Ann Plast Surg, ,60 (3 ),283-287

2008- Ann Plast Surg

Norris, D A; Ryan, S B; Kissinger, R M; Fritz, K A; Boyce, S T (1985. )Systematic comparison of antibody-mediated mechanisms of keratinocyte lysis in vitro. Journal of immunology (Baltimore, Md. : 1950), ,135 (2 ),1073-9

1985- J Immunol

Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T (2012. )Differential contributions of deep and superficial keloid fibroblasts revealed using a novel in vivo model of keloid scar.Plast Reconstruct Surg, ,129 (6 ),1259-71

2012- Plast- Reconstr- Surg

Barai, Namrata D; Boyce, Steven T; Hoath, Steven B; Visscher, Marty O; Kasting, Gerald B (2008. )Improved barrier function observed in cultured skin substitutes developed under anchored conditions.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), ,14 (4 ),418-24

2008- SRT

Wang, Q.; Wang, J.J.; Boyce, S.T.; Fischer, J.E.; Hasselgren, P-O. (1998. )Endotoxemia and IL-1beta stimulate mucosal IL-6 production in different parts of the gastrointestinal tract .J Surg Res, ,76 (1 ),27-31

McFarland, Kevin L; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M (2008. )Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,16 (4 ),534-41

2008- WRR

Bettger, W J; Boyce, S T; Walthall, B J; Ham, R G (1981. )Rapid clonal growth and serial passage of human diploid fibroblasts in a lipid-enriched synthetic medium supplemented with epidermal growth factor, insulin, and dexamethasone. Proceedings of the National Academy of Sciences of the United States of America, ,78 (9 ),5588-92

1981- Bettger-PNAS-USA.pdf

Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T (2008. )Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture.Tissue engineering. Part A, ,14 (5 ),583-93

2008- TE- Kalyanaraman

Powell, H M; Boyce, S T (2008. )Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes.Journal of biomedical materials research. Part A, ,84 (4 ),1078-86

2008- JBMR

Boyce, S.T. (1998. )Cultured skin substitutes for treatment of burn wounds .Med Res Prog Shriners Hospitals for Children 1998, ,3-8

1999- Med Res Prog Shriners Hospital

Boyce, S.T; Glatter, R.; and Kitzmiller, W.J. (1995. )Treatment of chronic wounds with cultured cells and biopolymers: a pilot study .Wounds, ,7 (1 ),24-29

1995- Wounds

Goretsky, M J; Breeden, M; Pisarski, G; Harriger, M D; Boyce, S T; Greenhalgh, D G (1995. )Capillary morphogenesis during healing of full-thickness skin grafts: an ultrastructural study.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,3 (2 ),213-20

1995- Goretsky- WRR

Boyce, S T; Stompro, B E; Hansbrough, J F (1992. )Biotinylation of implantable collagen for drug delivery.Journal of biomedical materials research, ,26 (4 ),547-53

1992- J Biomed Mat Res

Sander, Edward A; Lynch, Kaari A; Boyce, Steven T (2014. )Development of the mechanical properties of engineered skin substitutes after grafting to full-thickness wounds.Journal of biomechanical engineering, ,136 (5 ),051008

2014- JBE

Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M (2013. )Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,21 (4 ),530-44

2013- WRR

Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M (2012. )Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,20 (4 ),544-51

2012- WRR

Barai, Namrata D; Supp, Andrew P; Kasting, Gerald B; Visscher, Marty O; Boyce, Steven T (2007. )Improvement of epidermal barrier properties in cultured skin substitutes after grafting onto athymic mice.Skin pharmacology and physiology, ,20 (1 ),21-8

2007- Skin Pharmacol Physiology

Porembka, D.T.; Kier, A; Sehlhorst, S; Boyce, S; Orlowski, J.P; and Davis, K. (1993. )The pathophysiologic changes following bile aspiration in a porcine lung model .Chest, ,104 (3 ),919-924

1993-Chest

Boyce, S T (1999. )Methods for the Serum-Free Culture of Keratinocytes and Transplantation of Collagen-GAG-Based Skin Substitutes.Methods in molecular medicine, ,18 ,365-89

1999- Methods in Molec Med.

Sakai, J; Hung, J; Zhu, G; Cardell, R; Boyce, S; Kao, WW-Y (1991. )Collagen metabolism during healing of lacerated rabbit corneas. Exptl Eye Res, ,52 ,237-244

1991- Exptl Eye Res

Boyce, S T; Christianson, D J; Hansbrough, J F (1988. )Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes.Journal of biomedical materials research, ,22 (10 ),939-57

1988- J Biomed Mat Res

Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M (2010. )Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice.The Journal of investigative dermatology, ,130 (2 ),587-601

2010- Klingenberg-JID

Hansbrough JF; Boyce ST (1984. )What criteria should be used for designing artificial skin replacements and how well do the current materials meet these criteria. .J. Trauma, ,24 (9 Supplement ),S31-S35

1984- J Trauma

Boyce, ST; Ham, RG (1985. )Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free media. J Tiss Cult Meth, ,9 (2 ),83-93

1985- J Tiss Cultivation Method

Boyce, S T; Cooper, M L; Foreman, T J; Stompro B E; Hansbrough, J F. (1989. )Serum-free culture of human epidermal keratinocytes and application to skin substitutes. .Proceedings of the Second Bioscience Conference, Tokyo Metropolitan University, Tokyo, Japan, ,18-27

1989- Proceedings of the Second Bioscience Conference

Boyce ST (1987. )Medical and biological criteria for preparation from cultured keratinocytes and a collagen-chondroitin-sulfate membrane of a human skin replacement for treatment of full-thickness skin loss injuries. Proceedings of the 17th World Congress on Dermatology Workshop-14, ,210

1987- Proceedings of the 17th World Congress on Dermatology

Invited Publications

Boyce ST (1990. )Benchmarks: Alternative Methods in Toxicology. (Book Review) .J Invest Dermatol, 94 (1 ),155

1990- J Invest Dermatol

Boyce ST, S Michel, M Regnier, B Shroot, R Schmidt (1990. )Reconstructed skin from cultured human keratinocytes and fibroblasts on a collagen-GAG biopolymer substrate. .Skin Pharmacol, 3 (2 ),136-143

1990- Skin-Pharmacol

Boyce ST (1993. )Current usage, trends and research in skin grafts. SEOPF Tissue Banking Newsletter, 3 (1 ),1-4

1993- SEOPF Tissue Banking Newsletter

Boyce ST, JH James and ML Williams (1993. )Nutritional regualtion of cultured analogues of human skin. J Toxicol- Cutan Ocular Toxicol, 12 (2 ),161-171

1993- J Toxicol-Cutan Ocular Toxicol

Boyce ST (1994. )Epidermis as a secretory tissue. (editorial) .J Invest Dermatol, 102 ,8-10

1994- J Invest Dermatol

Boyce ST, R Glatter, and WJ Kitzmiller (1995. )Case studies: Treatment of chronic wounds with cultured skin substitutes. Ostomy/Wound Management , 41 (2 ),26-33

1995- Ostomy-Wound Management

Boyce ST (1996. )Cultured skin substitutes: a review. .Tissue Engineering, 2 (4 ),255-266

1996- Tissue Engineering

Boyce ST (1997. )Human Cell Culture Protocols .J Invest Dermatol, 108 ,235

Vicanova J, ST Boyce, MD Harriger, AM Weerheim, JA Bouwstra, and M Ponec (1998. )Stratum corneum lipid structure and composition in cultured skin substitutes is restored after grafting to athymic mice. J Invest Dermatol Symp Proc, 3 (2 ),114-120

1998- J Invest Dermatol Symp Proc

Boyce ST (1998. )Skin substitutes from cultured cells and collagen- GAG polymers. Medical and Biological Engineering and Computing , 36 ,791-800

1998- Medical and Biological Engineering

Boyce ST (1999. )Cultrued skin substitutes for burns. Med Res Prog Shriners Hospitals for Children 1999, 55-56

Boyce ST (2001. )Design principles for composition and performance of cultured skin substitutes. Burns, 27 (5 ),523-533

2001- Burns

Boyce ST (2001. )Invited discussion for: Morimotot et al, In vivo cultured skin composted of two-layer collagen sponges with preconfluent cells. Ann Plast Surg, 47 (1 ),74-82

Boyce ST and GD Warden (2002. )Principles and practices for cutaneious wound repair with cultured cells and biopolymers. .Amer J Surg, 183 ,445-456

2002- Amer J Surg

Boyce ST (2004. )Fabrication, quality assurance and assessment of cultured skin substtitues for treatment of skin wounds. Biochem Eng, 20 ,107-112

2004- BEJ

Supp DM and ST Boyce (2005. )Engineered skin substitutes; practices and potentials. Clinics Dermatol, 23 (4 ),403-412

2005- Clinics Dermatol

Gibran SN, ST Boyce, and DG Greenhalgh (2007. )Cutaneous wound healing. J Burn Care Res, 28 (4 ),577-579

Boyce ST (2012. )In, A tribute to Richard G. Ham, Ph.D, 1932-2011; ed., WL McKeehan .In Vitro Cell and Developmental Biology, 48 (5 ),259-70

2012- IVA

Singer AG, DH Ahrenholz, P Chang, RAF Clark, R Fey, P Fidler, W Garner, N gibran, D Greenhalgh, S Honari, L Jones, R Kagan, J Kirby, J Leggett, N Meyer, C Reigart, K Richey, L Rosenberg, J Weber, B Wiggins, and ST Boyce (2013. )Burn wound healing outcomes.J Burn Care and Res, 34 (4 ),381-385

2013- JBCR

Book Chapter

Boyce ST and RG Ham (1986 )Normal human epidermal keratinocytes In Vitro Models for Cancer Research; Vol 3, Carcinomas of the Mammary Gland, Uterus and Skin .(pp. 245-274).Boca Raton, Florida,CRC Press

Boyce ST, JF Hansbrough and DA Norris (1988 )Cellular responses of cultured human epidermal keratinocytes as models of toxicity to human skin Alternative Methods in Toxicology; Vol. 6, Progress in In Vitro Toxicology .(pp. 27-37).New York, New York,Leibert Publishers

Boyce ST, TJ Foreman and JF Hansbrough (1988 )Functional wound closure with dermal epidermal skin substitutes prepared in vitro Tissue Engineering; UCLA Symposia on Molecular and Cellular Biology, Vol. 107 .(pp. 81-86).NY, NY,Alan R Liss, Inc.

Boyce ST and IA Holder (1995 )Criteria and assays for selection of topical antimicrobial agents for use with cultured skin for burns. Molecular Pathogenesis of Surgical Infections .(pp. 96-102).

Boyce ST (1996 )Skin repair with cultured cells and biopolymers Human Biomedical Applications .(pp. 347-377).Totowa, NJ,The Humana Press, Inc.

Boyce ST (1997 )Cultured skin for wound closure Skin Substitute Production by Tissue Engineering: Clinical and Fundamental Applications .(pp. 75-102).Austin, TX,RG Landes Company

Boyce ST (1999 )Methods for serum-free culture of keratinocytes and transplantation of collagen-GAG based composite grafts Methods in Molecular Medicine, Volume 18: “Methods in Tissue Engineering”, Chapter 28 .(pp. 365-389).Totowa, NJ,Humana Press, Inc.

Supp DM and ST Boyce (2001 )Genetic modification of cultured skin substitutes “Cultured Human Keratinocytes and Tissue Engineered Skin Substitutes .(pp. 60-71).

Boyce ST (2002 )Regulatory issues and standardization. Chapter 1 Methods of Tissue Engineering .(pp. 3-17).San Diego, CA,Academic Press

Supp DM and ST Boyce (2003 )Cutaneous gene therapy with cultured skin substitutes Human Biomedical Applications .(pp. 155-172).New York, NY,Marcel Dekker, Inc.

Boyce ST and DM Supp (2005 )Skin substitutes: theoretical and developmental considerations Functional and Aesthetic Reconstruction of Burn Patients .(pp. 113-128).New York, NY,Marcel Dekker, Inc.

Boyce ST (2005 )Fabrication, quality assurance and assessments of cultured skin substitutes Burns: Critical Care and Surgery .(pp. 225-230).Caracas, Venezuela,Ateproca Press

Supp DM and Boyce ST (2006 )Bioengineering of human skin substitutes.Chapter 47 Biomedical Engineering Handbook .(pp. 47-1 to 47-17).Boca Raton, FL,CRC Press, Inc.

Powell HM and ST Boyce (2008 )Cultured skin substitutes. Chapter 12 Biomaterials for Treating Skin Loss .Abington, UK,Woodhead Publishing, Ltd

Powell HM and ST Boyce (2011 )Tissue engineering of skin An introduction to biomaterials and their applications; 2nd Edition .Boca Raton, FL,CRC Press, Inc

Boyce ST (2014 )Engineered skin substitutes: principles and practices Burns: Critical Care and Surgery, second edition .Caracas, Venezuela,Ateproca Press

Boyce ST (2014 )Translational research with engineered skin substitutes Burns: Critical Care and Surgery, second edition .Caracas, Venezuela,Ateproca Press

Boyce ST and DM Supp (2015 )Biologic skin substitutes Tissue Engineering and Regenerative Medicine of Skin .New York, New York,Elsevier Press

Presentations
Invited Presentations

Cutaneious Biology Foundation (10-1982. )Biology of the keratinocyte in vitro.

Standord University School of Medicine, Department of Dermatology (02-1983. )Calcium regulated proliferation and differentiation of normal human epidermal keratinocytes in vitro .

Joint Sino American Burn Associations; Panel moderator on skin replacements and skin substitutions (10-1985. )First sino american conference on burn injuries .Chongqing, China.

17th World Congress of Dermatology (05-1987. )Cultured keratinocytes and synthetic skin .Berlin, Germany.

Center for International Research of Dermatology (CIRD) (06-1987. )Culture of human epidermal keratinocytes on synthetic biomembranes .Valbonne, France.

Center for Alternatives to Animal Testing (11-1987. )Progress in in vitro toxicology .Johns Hopkins University, Baltimore, Maryland.

UCLA Symposia on Molecular and Cellular Biology (02-1988. )Tissue engineering of human skin .Lake Tahoe, California.

American Association of Tissue Banks (08-1988. )Banking of cultured skin substitutes: Current Status and Future Prospects .San Diego, California.

International Society for Burn Injuries (10-1988. )Wound healing and wound management .Chicago, Illinois.

Second Bioscience Conference (11-1988. )Serum-free culture of human epidermal keratinocytes and applications to skin substitutes .Tokyo Metropolitan University, Tokyo, Japan.

Citizen Ambassador Program; People to People Bioprosthetics Delegation to the People's Republic of China (05-1989. )Beijing, Shanghai, Chengdu, Hong Kong, China.

International Symposium on Artificial Skin, Koken BioScience Institute (06-1989. )Combined bio-synthetic dermis and cultured human skin cells for wound closure .Tokyo, Japan.

51st Annual Meeting of the Society for Investigative Dermatology (05-1990. )Keratinocyte growth .Washington, D.C.

Sixth Intl Workshop on In Vitro Toxicology (10-1990. )Reconstructed skin from cultured human cells and biopolymers .Seillac, France.

Department of Pharmacology (10-1990. )Biopolymer materials for culture and transplantation of human cells .Hopital Eduord Herriot, Lyon, France.

Department of Dermatology, Boston University School of Medicine (09-1990. )Transplantation of cultured skin substitutes .Boston, Massachusetts.

Department of Biology, Case Western Reserve University (12-1990. )Skin wound closure with cultured human cells, biopolymers and growth factors .Cleveland, Ohio.

Department of Research, American Red Cross (06-1991. )Pre-clinical and clinical studies with cultured skin substitutes .Bethesda, Maryland.

Department of Chemical Engineering, University of Cincinnati Center of Excellence of Membrane Technology Seminars (11-1991. )Skin as a biological membrane .

American Burn Association, Breakfast Session Co-Moderator (04-1992. )Artificial skin .Salt Lake City, Utah.

Department of Biological Sciences (04-1992. )Composite grafts of cultured human skin cells and biopolymers for burns .Wright State University, Dayton, Ohio.

Organogenesis, Inc (06-1992. )Methodologies and in vitro applications for organotypic skin culture models .New York, New York.

Fernstrom Symposium (06-1992. )Criteria and assays for selection of topical antimicrobial agents for use with cultured skin for burns .Lund, Sweden.

American Association of Tissue Banks (08-1992. )Allogeneic skin and cultured cells for permanent closure of skin wounds .San Diego, California.

South Eastern Organ Procurement Foundation (01-1993. )Current usage/trends/research in skin grafts .Orlando, Florida.

American Burn Association, Ad Hoc Moderator (03-1993. )Frontiers in burn wound care .Cincinnati, Ohio.

L'Oreal Cosmetics (08-1993. )Regeneration of skin pigmentation after transplantation of cultured melanocytes to athymic mice .Paris, France.

Department of Dermatology, University of Utah (08-1993. )Skin substitutes using cultured cells and biopolymers .Salt Lake City, Utah.

Department of Surgery (09-1993. )Wound closure with cultured cells and biopolymers .Indiana University, Indianapolis, Indiana.

Genzyme Corporation (10-1993. )Regeneration of epidermal barrier and pigmentation in cultured skin for wound treatment .Framingham, Massachusetts.

American Burn Association, Breakfast Session Co-Moderator (04-1994. )Artificial skin .Orlando, Florida.

American Burn Association, Correlative Session Co-moderator (04-1994. )Cultured epithelial autografts and the burn wound .Orlando, Florida.

University of Miami (04-1994. )Treatment of chronic wounds with cultured skin substitutes .Miami, Florida.

Laboratory for Experimental Organogenesis (05-1994. )Principles and practices for wound treatment with cultured skin substitutes .Hospital St. Sacrement, Quebec City, Canada.

American Association of Tissue Banks (08-1994. )Biological, technical and regulatory considerations for banking of cultured skin .San Francisco, California.

Dutch Society for Biomaterials (10-1994. )Treatment of skin wounds with cultured cells and biopolymers .Lunteren, The Netherlands.

American Burn Association, Breakfast Session Co-moderator (04-1995. )Substrate choices for cultured tissue .Albuquerque, New Mexico.

American Burn Association; Session Co-moderator (04-1995. )Burn wound biology .Albuquerque, New Mexico.

American Burn Association, Plenary Session (04-1995. )Skin replacement strategies: where have we been, and where are we going? .Albuquerque, New Mexico.

Wound Healing Society, Plenary Session (04-1995. )Closure of full-thickness burns with grafts of cultured skin cells and biopolymers .Minneapolis, Minnesota.

US Food and Drug Administration, Intercenter Focus Group on Wound Healing (07-1995. )Quantification of wound healing in burns .Gaithersburg, Maryland.

Skin Council of the American Association of Tissue Banks (09-1995. )Compliance of cultured allogeneic skin cells with regulatory requirements for safe use of cadaveric human skin .Atlanta, Georgia.

New Technologies Workshop; Microbiological Associates (09-1995. )Principles for fabrication and applications of cultured skin substitutes .Bethesda, Maryland.

Department of Surgery, University of Alberta (10-1995. )Biology and surgery of cultured skin substitutes for wound closure .Edmonton, Alberta, Canada.

7th Polymer Symposium (11-1995. )Grafts of cultured cells and biopolymers for treatment of acute and chronic skin wounds .Kyoto University, Kyoto, Japan.

US FDA Part 15 Public Hearing on Autologous Cells (11-1995. )Factors to consider for culture and transplantation of skin cells .Gaithersburg, Maryland.

Dept of Biomedical Engineering; Univ of Virginia (12-1995. )Repair of acute and chronic skin wounds with cultured cells and biopolymers .Charlottesville, Virginia.

Clemson University, Department of Bioengineering (01-1996. )Engineering of skin substitutes for wound closure .Clemson University, Clemson, SC.

3M Life Sciences Technical Forum (01-1996. )Wound repair with cultured cells and biopolymers .Minneapolis, MN.

American Burn Association, Session Co-moderator (03-1996. )Skin replacements .Nashville, TN.

Federal Issues Committee of the American Burn Association, Panelist (03-1996. )Dialogue with FDA: definitions and assessments of healing in burn wounds .Nashville, TN.

Wound Healing Society, Plenary Session (05-1996. )Composite skin replacement .Boston, MA.

Wound Healing Society, Instructional Workshop (05-1996. )Quantitative assessment of wounds with non-invasive instrumentation .Boston, MA.

Oregon Health Sciences University (06-1996. )Treatment of burns and chronic wounds with cultured skin substitutes .Portland, OR.

Burn Care: State of the Art, Current Therapy and Future Trends (11-1996. )Skin substitutes for burn care .Shriners Burns Institute, Cincinnati, OH.

FDA course on Tissue Engineering (02-1997. )Principles and practices for engineering of skin substitutes .Bethesda, MD.

American Burn Association, Graduate Course on Wound Healing (03-1997. )Cultured skin substitutes in burn care .New York, NY.

American Burn Association, correlative session co-moderator (03-1997. )Hypertrophic scar .New York, NY.

Perspectives in Percutaneous Penetration (04-1997. )Cultured skin substitutes grafted to athymic mice .La Grande Motte, Languedoc, France.

Proctor & Gamble Company, scientific seminar (11-1997. )Cytokines in the skin .Cincinnati, OH.

American Burn Association, breakfast session co-moderator (03-1998. )Topical scar remodeling .Chicago, IL.

Plenary presentation. Eighth annual meeting of the Wound Healing Society (06-1998. )Expression by cultured skin substitutes of molecular mediators and tissue phenotypes .Salt Lake City, UT.

12th International Symposium on Bioengineering and the Skin (06-1998. )Standards for engineering of skin substitutes .keynote address, Boston, MA.

Ohio Burn Team Task Force annual symposium (10-1998. )Why and how to use cultured skin for burns .Cincinnati, OH.

Society for In Vitro Biology Session in Depth (06-1999. )The normal biology of human skin and cutaneous wound healing .New Orleans, LA.

Society for In Vitro Biology; Session Chairman (06-1999. )Tissue engineering with cultured cells and biopolymers: a clinical reality .New Orleans, LA.

Wound Healing Society, plenary session (06-1999. )Grafts with autologous, homologous, heterologous, and artificial skin .Minneapolis, MN.

International Business Communications (06-1999. )Cultured skin substitutes for closure of cutaneous wounds .Boston, MA.

American Burn Association, Bioengineering Special Interest Group (03-2000. )Quantitative assessment of tissue-engineered skin for burns .Las Vegas, NV.

American Burn Association, breakfast session co-moderator (03-2000. )Recent advances in wound coverage; weighing the options .Las Vegas, NV.

First L’Oreal International Symposium on the Science and Technology of Skin (10-2000. )Cultured skin substitutes for closure of full-thickness skin wounds .Lyon, France.

American Burn Association; Breakfast session (04-2001. )Biological skin substitutes: are they worth the cost? .Boston, MA.

Wound Healing Society, session moderator (05-2001. )Skin substitutes and wound treatment .Albuquerque, NM.

Swiss Federal Institute of Technology; Department of Chemical Engineering (09-2001. )Engineering of human skin .Zurich, Switzerland.

American Association of Tissue Banks (11-2001. )Human allograft skin as a source of cells for cultured skin substitutes .Cincinnati, OH.

Department of Biology (11-2001. )Cutaneous wound repair with cultured cells and biopolymers .University of Dayton.

Timberline Symposium on Epithelial Cell Biology (02-2002. )Epithelial biology and skin repair .Portland, OR.

American Burn Association; postgraduate course (04-2002. )Artificial skin: It’s impact on scar formation .Chicago, IL.

American Burn Association; plenary presentation (04-2002. )Translational research to improve burn care . Chicago, IL.

American Burn Association (04-2002. )Innovations in burn care .Chicago, IL.

American Burn Association; session moderator (04-2002. )Wound care: skin substitutes/basic science .Chicago, IL.

British Burn Association (05-2002. )Burn wound closure with cultured skin substitutes .Birmingham, UK.

Cell Therapies and Tissue Engineering (06-2002. )Culture and transplantation of skin or cornea epithelium .Case Western Reserve University, Cleveland, OH.

US Food and Drug Administration (06-2002. )Combination products containing live cellular components .Rockville, MD.

International Society for Burn Injuries (08-2002. )Basic science of skin replacement - state of the art .Seattle, WA.

International Society for Burn Injuries; session moderator (08-2002. )Tissue engineering .Seattle, WA.

L’Oreal Symposium on Skin Aging (09-2002. )Aging factors in wound repair with cultured skin substitutes .Cleveland, OH.

International Society for Bioengineering of the Skin (10-2002. )Biophysical properties of cultured skin substitutes .Baltimore, MD.

American Burn Association; session moderator (04-2003. )Wound Management .Miami, FL.

Society for Investigative Dermatology (05-2003. )Cellular Dermato-therapeutics .Miami, FL.

Gordon Conference on Mammalian Skin Barrier (08-2003. )Barrier formation in cultured skin substitutes .Providence, RI.

American Burn Association; breakfast session moderator (04-2004. )Tissue engineering for reconstruction .Vancouver, British Columbia, Canada.

American Burn Association; correlative session moderator (04-2004. )Reconstruction .Vancouver, British Columbia, Canada.

Osaka University Dept of Chem Eng (09-2004. )Automated systems for tissue engineering . Osaka, Japan.

Keynote address; Australia-New Zealand Burn Association (ANZBA) meeting (Three presentations total) (09-2004. )Skin repair with cultured cells and biopolymers . Adelaide, Australia.

Australia-New Zealand Burn Association (ANZBA) meeting (09-2004. )Tissue regeneration for wound closure .Adelaide, Australia.

L’Oreal Recherche; program committee (10-2004. )Science and technology of skin engineering .Lausanne, Switzerland.

American Academy of Pediatrics (10-2005. )Advances in pediatric burn care .Washington, DC.

American Burn Association; session moderator (04-2006. )Getting started in research .Miami, FL.

British Society for Cell Biology (03-2006. )Stem cells in wound healing .The Royal Society, London, UK.

American Burn Association (04-2006. )Getting started in research .Las Vegas, NV.

Wound Healing Society (05-2006. )Tissue engineering for skin wounds .Scottsdale, AZ.

Pan American Pigment Cell Society (09-2006. )Transplantation of human melanocytes to restore cutaneous pigmentation .Cincinnati, OH.

Burn Research State of the Science (10-2006. )Future directions in burn wound healing .Washington, DC.

Multi-Agency Tissue Engineering Science (MATES) Workshop (02-2007. )Opportunities and obstacles with engineered human skin .Arlington, VA.

Graduate Course; American Burn Association (03-2007. )Tissue engineering of human skin for burns .San Diego, CA.

Moderator, Sunrise symposium; American Burn Association (03-2007. )Current status of skin substitutes .San Diego, CA.

Moderator, Correlative session III; American Burn Association (03-2007. )Basic science of burn wounds .San Diego, CA.

Advanced Technology Applications for Combat Casualty Care (ATACCC) (08-2007. )Engineered human skin for military burn injuries .St. Petersburg, FL.

Moderator, Correlative session III; American Burn Association (04-2008. )Wound Management .Chicago, IL.

Award judge for poster presentations; American Burn Association (04-2008. )Professors’ Poster Rounds .Chicago, IL.

Graduate Course; American Burn Association (05-2008. )Alternatives for permanent wound closure .Chicago, IL.

Symposium on Tissue Engineering; International Society for Burn Injuries (09-2008. )Engineered skin for burns: the Shriners Experience .Montreal, Quebec, Canada.

Heal Ohio (10-2008. )Burn wound treatments with engineered human skin .Akron General Medical Center, Akron, OH.

9th Symposium on Biomaterials (10-2008. )Engineered skin for burn wound closure .New Jersey Center for Biomaterials, New Brunswick, NJ.

Armed Forces Institute for Regenerative Medicine (01-2009. )Burn wound treatment with engineered skin substitutes .St. Pete’s Beach, FL.

Moderator, Correlative session III; American Burn Association (03-2009. )Wound Management .San Antonio, TX.

Moderator, Correlative session 2; Armed Forces Institute for Regenerative Medicine (01-2010. )Stem cell isolation, propagation, differentiation and transplantation .St. Pete’s Beach, FL.

Correlative session 3; Armed Forces Institute for Regenerative Medicine (01-2010. )Translational research with engineered human skin .St. Pete’s Beach, FL.

Skin recovery collaborative; AlloSource (01-2010. )Clinical advances in skin substitutes .Cincinnati, OH.

University of Aachen (04-2010. )Dressings to stimulate cellular engraftment and inhibit microbial contamination of engineered skin substitutes .Aachen, Germany.

Society for Investigative Dermatology (05-2010. )Biological considerations of wound healing with engineered skin .Atlanta, GA.

Symposium on Clinical and Scientific Advances in Treatment of Poorly Healing Wounds (05-2010. )Engineered skin substitutes for treatment of burns: principles and practices .University of Illinois, Chicago, IL.

Special presentation to the Commander of the US Army Medical Research and Materiel Command (09-2010. )Autologous engineered skin substitutes .Rutgers University.

Interim Meeting; Armed Forces Institute for Regenerative Medicine (AFIRM) (12-2010. )Overview of animal models for transition to clinical studies .Crystal City, VA.

Moderator, breakout session; Interim Meeting; Armed Forces Institute for Regenerative Medicine (AFIRM) (12-2010. )Burns and scarless healing .Crystal City, VA.

Moderator, Correlative session 3; Armed Forces Institute for Regenerative Medicine (AFIRM) (01-2011. )Burn wounds and scarless healing .Clearwater, FL.

Breakout session 3 on Translational Research and Standardization; Armed Forces Institute for Regenerative Medicine (AFIRM) (01-2011. )Experiences and advice from IDE studies with engineered skin .Clearwater, FL.

Moderator, Correlative session II, American Burn Association (03-2011. )Wounds – Tissue Engineering .Chicago, IL.

Moderator, Correlative session XVI, American Burn Association (03-2011. )Wounds – Clinical .Chicago, IL.

Symposium on Adult Mesenchymal Stem Cells 2011 (08-2011. )Wound closure with adult stem cells .Cleveland, OH.

Keynote speaker, Australia-New Zealand Burn Association (Five presentations total) (10-2011. )Principles and practices for engineered skin substitutes for burns .Brisbane, Australia.

4th Annual Skin Workshop; Center for Dermal Research (10-2011. )Wound repair with engineered human skin .Rutgers University, New Brunswick, NJ.

Workshop moderator; Burn Quality Consensus Conference; American Burn Association (02-2012. )Wound Healing Quality Consensus Conference .Washington, DC.

Moderator, plenary session; All Hands Meeting; Armed Forces Institute for Regenerative Medicine (AFIRM) (02-2012. )Enabling Technologies .St Pete’s Beach, FL.

Transition to the Clinic Symposium; Department of Materials Science (03-2012. )Principles and practices for wound repair with engineered human skin .The Ohio State University.

Moderator, correlative session III, American Burn Association (04-2012. )Wounds-Tissue Engineering .Seattle, WA.

Grand Rounds Visiting Professor; Dept of Surgery; University of Nebraska Medical Center (09-2012. )Translational research with engineered human skin .Omaha, NE.

David M Heimbach, MD, Visiting Professor (11-2012. )Principles and practices in regenerative medicine for skin wounds . University of Washington Department of Surgery, Seattle, WA.

McGowan Institute Research Symposium (03-2013. )Robotic fabrication of engineered skin .University of Pittsburgh Department of Biomedical Engineering, Farmington, PA.

Moderator, Correlative session X, American Burn Association (03-2014. )Translational Science .Boston, MA.

Wound Healing Society and Symposium on Advanced Wound Care (04-2014. )Next generation grafts and matrices .Orlando, FL.

7th World Congress on Pediatric Burns (08-2014. )Tissue engineering and regenerative medicine to reduce scar .Boston, MA.

Wound Healing: Innovation and Discovery Symposium (12-2014. )Tissue engineered skin: principles, practices and potentials .Hawks Cay Key, FL.

Department of Surgery; University of Calgary (05-2015. )Wound repair and regeneration with engineered human skin .Calgary, Alberta, Canada.

Honors and Awards

06-1982 -08-1982 Macy Scholarship at Columbia University College of Physicians and Surgeons Physiology and Pathology for Cell Biologists

03-1983 -10-1983 Graduate Research Assistantship US Army Research and Development Command

11-1996 Faculty Achievement Award University of Cincinnati

02-1998 Heath Care Heroes, Innovator Award Cincinnati Business Courier; Cincinnati, OH

06-1998 Established Investigator Award Society for In Vitro Biology; Las Vegas, NV

03-1999 Clinical Research Award American Burn Association; Orlando, FL

1982 -1996 Seventh most cited first-author in the dermatology literature Arch Dermatol 135:299-302

05-2006 Established Entrepreneur Award University of Cincinnati

2014 Three of the top 100 citations in the burn literature from 1955-2011 J Burn Care Res 35:176-185

04-2015 Harvey Stuart Allen Award for Distinguished Service American Burn Association; Chicago, IL

Student Advising

Michael Glafkides, MD. Jul-Dec 86.Surgery Res Fellow; Univ of Calif San Diego

Mark Sherman, MD. May-Sep 86 . Res Fellow, Med Student; Univ of Calif San Diego

Charles Richardson, MD. May-Sep 86. Res Fellow, Med Student; Univ of Calif San Diego

Sandra Weiss, BS. Sep 87-Jun 88. Res Fellow, Undergrad Univ of Calif San Diego

Brett Stompro, MD. Jan 88-Jun 88. Surgery Res Fellow; Univ of Calif San Diego

Matthew Cooper, MD. Jul 88-Dec 88. Surgery Res Fellow; Univ of Calif San Diego

Jennifer Reid, MS. Sep 92-Nov 93. Masters; Univ of Cincinnati, Engineering

Michael Goretsky, MD. Jul 93-Jun 95. Surgery Res Fellow; Univ of Cincinnati

M. Dana Harriger, PhD. Jan 94-Jun 96. Res Fellow, Post-doc; Shriners Hospitals

Andrew P. Supp, BS. Jan 94-Dec 97. Masters; Univ of Cincinnati, Pharmacy

Cameron Q. Sheeler, BS. Sep 94-Dec 94. PhD; Univ of Cincinnati, Cell Biology

Rajeet Pannu, BS. Oct 95. Masters; Univ of Alberta, Cell Biology

Caroline LePoole, PhD. Jan-Jun 97. Res Fellow, Post-doc; Univ of Cincinnati, Surgery

Dorothy M. Supp, PhD. Jul 97-Dec 99. Res Fellow, Post-doc; Shriners Hospitals

Nikkiya Koval, BS. Jun 00-Aug 00. Res Fellow, Med Student; Univ of Cincinnati

Mark Kleiner, BS. Sep 00-Dec 04. Masters; Univ of Cincinnati, Chemistry

Saja Hamed, BS. Sep 00-Jun 04. PhD; Univ of Cincinnati, Pharmacy

Namrata Barai, MS. Sep 01-Jun 05 PhD; Univ of Cincinnati, Pharmacy

Balaji Kalyanaraman, MD. Sep 02-Jun 08. PhD; Univ of Cincinnati, Biomed Eng

Heather Powell, PhD. Dec 04-Jan 08. Res Fellow, Post-doc; Shriners Hospitals

Alexis Armour, MD. Oct 05-Sep 06. Surgery Res Fellow; Shriners Hospitals

Daewoo Han, BS. Sep 07-Aug 10. PhD; Univ of Cincinnati, Electrical Eng

Karen Cross, MD, PhD. Jan 10. PhD; Univ of Toronto, Inst of Med Sciences

Edward Sander, PhD. Aug 10-Jul 11. Res Fellow, Post-doc; Univ of Cincinnati, Surgery

Penkanok Sriwiriyanont, MS. Sep 09-Aug 12. PhD; Univ of Cincinnati, Biomedical Eng

Julie Lander, MD. Sep 14- . PhD; Cincinnati Children’s Research Foundation

Andrew Jajack, BS. Jan-May 15. Ind. Study; Univ of Cincinnati, Biomedical Eng

Service

(Shriner’s Burns Institute Research Conference )Director 1992 -1994

(Dean’s Committee on the Future of Basic Sciences at the UC College of Medicine )1994

(Mediator for College of Medicine in faculty grievance )1996

(Dean’s Task Force on the Future of the Department of Dermatology )1999

(Univ of Cincinnati Dept of Surgery Committee for Appointment, Reappointment, Promotion and Tenure )1999 -2005

(Univ of Cincinnati Dept of Surgery Committee for Appointment, Reappointment,Promotion and Tenure )2007 -2009

(Univ of Cincinnati Dept of Biomedical Engineering, Graduate Admissions Committee )2002 -2004

(University of Cincinnati Intellectual Property Committee (UC IPC) )2006 -2009

(Chair, UC IPC )2007 -2009

(Children’s Hospital Medical Center; Steering Committee for Chair of Pediatric Dermatology )2007 -2009

(Dean’s ad hoc Committee for Initial Inquiry of Scientific Misconduct )2008

(University of Cincinnati Budget and Priorities Committee )2012 -2016

(University of Cincinnati Medical Scientist Training Program; Faculty advisor )2012 -2014

(University of Cincinnati Review Committee for Dermatology Chair )2013 -2014

(University of Cincinnati Faculty Leave Committee )2013 -2016

(Univ of Cincinnati Dept of Surgery AAUP Faculty Review Committee )2014 -2015

Positions and Work Experience

2002 -BAD DATE Professor with tenure; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio

1999 -2002 Associate Professor with tenure; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio

1996 -1999 Associate Professor; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio

1989 -1997 Director, Electron Microscopy Laboratories; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio

1995 -1996 Research Associate Professor; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio

1989 -1995 Research Assistant Professor; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio

1990 -1995 Adjunct Assistant Professor; Department of Anantomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio

2011 -To Present Adjunct Professor, Program in Biological and Medical Engineering, University of Cincinnati Colleges of Medicine & Engineering, Cincinnati, Ohio

2004 -2010 Adjunct Professor, Department of Biomedical Engineering, University of Cincinnati Colleges of Medicine & Engineering, Cincinnati, Ohio

2002 -2004 Adjunct Associate Professor, Department of Biomedical Engineering, University of Cincinnati Colleges of Medicine & Engineering, Cincinnati, Ohio

1989 -To Present Senior Investigator; Research Department, Shriners Hospital for Children, Cincinnati, Ohio

1997 -2012 Director, Engineered Skin Laboratories; Research Department, Shriners Hospital for Children, Cincinnati, Ohio

1993 -1997 Voting Member; General and Plastic Surgery Device Panel of the Medical Devices Advisory Committee to the Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Maryland

1998 -2008 Ad Hoc Consultant, General and Plastic Surgery Devices Panel of the Medical Devices Advisory Committee to the Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Maryland

1985 -1988 Assistant Adjunct Professor; Department of Surgery, University of California San Diego Medical Center, San Diego, California

1983 -1984 Research Associate; Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado

1981 -1984 Pre-doctoral Fellow; Department of Molecular Cellular & Developmental Biology, University of Colorado, Boulder and Denver, Colorado

1975 -1981 University Researcher II, Laboratory Technician II and I, University of Colorado, Boulder and Denver, Colorado

Keywords

Engineered Skin, Polymer, Collagen, Cytokine,Fibroblast,Melanocyte,Angiogenesis,Burn Therapy,Human Tissue,Keratinocyte,Athymic Mouse,Wound Healing,Artificial Skin,Autoradiography,Immunochemistry,Oxygen Transport,Western Blotting,Angiogenesis Factor,Cardiovascular Agent,Skin Transplantation,Blood Flow Measurement,Cell Adhesion Molecule,Monophenol Monooxygenase,Mixed Tissue Cell Culture,Enzyme Linked Immunosorbent Assay,Ultrasound Blood Flow Measurement

Research and Practice Interests

Cell Biology, Tissue Regeneration, and Regenerative Medicine

Patents and Inventions

US Patent 4,673,649 Process of defined medium for growth of human epidermal keratinocyte cells. Boyce ST and RG Ham, Filed 1986 Co-Inventor

US Patent 4,940,666 Continuation in part of US Patent 4,673,649, "Process of defined medium for growth of human epidermal keratinocyte cells" Boyce ST and RG Ham, Filed 1990 Co-Inventor

European Patent 363,400 Method and apparatus for preparing composite skin replacements Boyce ST, Filed 1993 Inventor

US Patent 5,273,900 Method and apparatus for preparing composite skin replacements Boyce ST, Filed 1993 Inventor

US Patent 5,711,172 Apparatus for Preparing composite skin replacements Boyce ST, Filed 1998 Inventor

US Patent 5,976,878 Method and apparatus for preparing composite skin replacements Boyce ST, Filed 1999 Inventor

Us Patent 6,905,105 Apparatus for preparing a biocompatible matrix. Boyce ST, Filed 2005 Inventor

US Patent 7,452,720B2 Apparatus for preparing a biocompatible matrix. Boyce ST, Filed 2008 Inventor

European Patent 1,483,373 A surgical device for skin therapy or testing Boyce ST, Filed 2009 Inventor

US Patent 7,741,116 A surgical device for skin therapy or testing Boyce ST, Filed 2010 Inventor

Japanese Patent 4,555,576 A surgical device for skin therapy or testing Boyce ST, Filed 2010 Inventor

Canadian Patent 2,478,100 Apparatus for preparing a biocompatible matrix. Boyce ST, Filed 2012 Inventor

European Patent 1,483,365 Apparatus for preparing a biocompatible matrix. Boyce ST, Filed 2013 Inventor

European Patent 1,483,365 Apparatus for preparing a biocompatible matrix. Boyce ST, Filed 2013 Inventor

US Patent 8,450,108 A surgical device for skin therapy or testing Boyce ST, Filed 2013 Inventor

Japanese Patent 5,535,446 A surgical device for skin therapy or testing Boyce ST, Filed 2014 Inventor

US Patent 8,765,468 A surgical device for skin therapy or testing Boyce ST, Filed 2014 Inventor

Other Information

Department of Burn Surgery,

Preferred Information

Professor Emeritus, Boyce, Steven PhD

Contact Information

Research - Research Department at Shriners Burns Hospital
3229 Burnet Avenue
Ohio, 45229-3095
Phone: (513)872-6080
Fax: (513)872-6107
stboyce@shrinenet.org

Department of Surgery at University of Cincinnati
P.O. Box 670558
Ohio, 45267-0558
steven.boyce@uc.edu

Headshot of Winston Whei Yang Kao

Winston Whei Yang Kao

Professor , COM Ophthalmology

5860 Care/Crawley

513-558-2802

The ultimate goal of our research project is to provide a better understanding of diseases which cause blindness, so that we can develop better treatment. We study the structure-function relationships of eye-specific genes which are vital for the maintenance of vision. Two research projects which are mutually supportive are: 1). Regulation of Cornea-specific K12 keratin gene expression, and 2). Corneal wound-healing. K12 keratin, exclusively expressed by corneal epithelial cells, is vital for normal corneal functions, and also plays an important role in corneal wound-healing. We are using the transgenic approach to examine the role of cytokines, receptors and/or other gene products in corneal wound-healing and development.
Research Support

Grant: #R01 EY011845 Investigators:Kao, Winston Whei Yang 09-01-2006 -08-31-2012 National Eye Institute Structure/Function Relationship of the Lumican Gene Role:PI $2,151,626.00 Active Level:Federal

Investigators:Kao, Winston Whei Yang 09-01-2005 -10-31-2005 Research to Prevent Blindness, Inc. RPB International Research Scholar Award Role:PI $1,750.00 Closed Level:Private Non-Profit

Investigators:Kao, Winston Whei Yang 01-01-2003 -12-31-2003 Research to Prevent Blindness, Inc. RPB Senior Scientific Investigator Award Role:PI $65,000.00 Closed Level:Private Non-Profit

Grant: #R01 EY010556 Investigators:Kao, Winston Whei Yang 06-01-2004 -05-31-2010 National Eye Institute K12 Expression Cornea-Type Epithelial Differentiation Role:PI $2,187,323.43 Closed Level:Federal

Grant: #5-R03-EY-14207-03-A0-S0-E0 Investigators:Kao, Winston Whei Yang 08-01-2002 -07-31-2006 National Eye Institute Mouse Lines Overexpressing rtTa and Cre in Corneal Epithelium Role:PI $459,000.00 Closed Level:Federal

Grant: #5-R01-EY-09368-13-A0-S0-E0 Investigators:Kao, Winston Whei Yang 08-01-2002 -07-31-2007 National Eye Institute Proteoglycans in Normal and Scarred Corneas Role:PI $270,526.00 Closed Level:Federal

Grant: #5-R01-EY-013755-04-A0-S0-E0 Investigators:Kao, Winston Whei Yang 07-01-2002 -06-30-2007 National Eye Institute Roles of Growth Factors on Corneal Morphogensis Role:PI $1,695,498.40 Closed Level:Federal

Grant: #5-R01-EY-10556-04-A0-S0-E0 Investigators:Kao, Winston Whei Yang 08-01-1995 -07-31-2000 National Eye Institute Structure and Function of Corneal Keratin K12 Gene Role:PI $831,811.00 Closed Level:Federal

Grant: #5-R01-GM-50959-05-A0-S0-E0 Investigators:Kao, Winston Whei Yang 07-01-1997 -03-31-2000 National Institute of General Medical Sciences Growth Factors and Impaired Wound Healing Role:PI $15,977.00 Closed Level:Federal

Grant: #5-R01-EY-11845-04-A0-S0-E0 Investigators:Kao, Winston Whei Yang 04-01-1999 -03-31-2004 National Eye Institute Structure-Function Relationship of Lumican Role:PI $1,101,177.00 Closed Level:Federal

Grant: #R01 EY013755 Investigators:Kao, Winston Whei Yang; Liu, Chia-Yang; Meij, Johanna T; Xia, Ying 12-01-2008 -11-30-2013 National Eye Institute Roles of Growth Factors on Corneal Morphogenesis Role:PI $2,281,831.00 Active Level:Federal

Grant: #R01 EY015227 Investigators:Ho, Shuk Mei; Kao, Winston Whei Yang; Puga, Alvaro; Tam, Neville Ngai Chung; Xia, Ying 06-01-2009 -05-31-2014 National Eye Institute The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis Role:Collaborator $1,759,938.00 Active Level:Federal

Grant: #2 R01 EY012486-08A1 Investigators:Kao, Winston Whei Yang; Liu, Chia-Yang; Liu, Hongshan 09-01-2009 -08-31-2011 National Eye Institute Role of Keratocan in Corneal Biology Role:Collaborator $785,000.00 Closed Level:Federal

Grant: #CK 1603 Investigators:Kao, Winston Whei Yang 07-01-2009 -08-31-2013 Ohio Lions Eye Research Foundation 2009 Eye Research Grant Role:PI $70,500.00 Active Level:Private Non-Profit

Grant: #T32 NS007453 Investigators:Broderick, Joseph; Herman, James; Kao, Winston Whei Yang; Strakowski, Stephen 07-01-2010 -06-30-2015 National Institute of Neurological Disorders and Stroke Predoctoral Training Program in the Neurosciences Role:Collaborator $629,724.00 Active Level:Federal

Grant: #RPB2011JA Investigators:Kao, Winston Whei Yang 07-01-2011 -06-30-2012 Research to Prevent Blindness, Inc. 2011 Research to Prevent Blindness (RPB) International Research Scholar Award Role:PI $3,500.00 Active Level:Private Non-Profit

Grant: #R21 EY021768 Investigators:Babcock, George; Kao, Winston Whei Yang; Liu, Hongshan 09-30-2011 -08-31-2015 National Eye Institute Cell Therapy of Corneal Diseases with Umbilical Mesenchyme Stem Cells Role:PI $1,705,844.00 Active Level:Federal

Grant: #R01EY011845 Investigators:Call, Mindy; Kao, Winston Whei Yang; Xia, Ying 09-01-2014 -06-30-2018 National Eye Institute Structure/Function Relationship of the Lumican Gene Role:PI $546,015.00 Awarded Level:Federal

Grant: #Saenger eqmt grant Investigators:Kao, Winston Whei Yang 07-01-2014 -12-31-2014 Cincinnati Sight Restoration Foundation Saenger Grant 2014 Role:PI $22,150.00 Awarded Level:Private Non-Profit

Grant: #R01 EY015227-10A1 Investigators:Kao, Winston Whei Yang; Puga, Alvaro; Xia, Ying 12-01-2014 -11-30-2019 National Eye Institute The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis Role:Collaborator $395,729.00 Active Level:Federal

Grant: #EY022502 SubK Yr 1 Investigators:Kao, Winston Whei Yang 09-01-2014 -08-31-2015 TissueTech, Inc. Engineering of Human Corneal Endothelial Grafts Role:PI $84,474.00 Awarded Level:Industry

Grant: #LSU/RPB Investigators:Kao, Winston Whei Yang 08-01-2015 -07-31-2016 Research to Prevent Blindness, Inc. Creation and Characterization of Mouse Mutant Carrying N120S in Ubiad1 Gene Role:PI $30,000.00 Active Level:Private Non-Profit

Grant: #Glaucoma Investigators:Kao, Winston Whei Yang; Yuan, Yong 10-01-2016 -09-30-2017 Glaucoma Foundation, The Characterization of a mouse model of glaucoma with exfoliation syndrome Role:Collaborator $40,000.00 Active Level:Private Non-Profit

Grant: #Fellowship Check# 1116 Investigators:Kao, Winston Whei Yang 09-01-2016 -08-31-2017 Ohio Lions Eye Research Foundation Ohio Lions Eye Research Fellowship Application FY 2017 Role:PI $10,000.00 Active Level:Private Non-Profit

Grant: #Fellowship Check# 1159 Investigators:Kao, Winston Whei Yang 09-15-2017 -09-14-2018 Ohio Lions Eye Research Foundation Effect of Extracellular Matrix Components on Umbilical Cord derived Mesenchymal Stem Cells (UMSCs) Role:PI $30,511.00 Active Level:Private Non-Profit

Grant: #Check# 1157-Eye Research Investigators:Kao, Winston Whei Yang 09-15-2017 -09-14-2018 Ohio Lions Eye Research Foundation Gene and Cell Therapy of Ocular Surface Diseases Role:PI $20,000.00 Active Level:Private Non-Profit

Grant: #Check # 1158 AMD Research Investigators:Kao, Winston Whei Yang; Park, Yoonjee 09-15-2017 -09-14-2018 Ohio Lions Eye Research Foundation “On-demand” Long-Term Drug Delivery for Age-Related Macular Degeneration Treatment Role:PI $10,000.00 Active Level:Private Non-Profit

Grant: #CEB Grant Investigators:Fox, Mindy; Kao, Winston Whei Yang 03-01-2018 -02-28-2019 Cincinnati Eye Bank Treatment of Dog Dry Eye Diseases with Umbilical Mesenchymal Stromal/Stem Cells Role:PI $25,000.00 Active Level:Private Non-Profit

Grant: #IGNITE Grant Investigators:Fox, Mindy; Kao, Winston Whei Yang; Yuan, Yong 07-01-2018 -06-30-2019 The Cincinnati Eye Institute Foundation CRISPR Gene Editing for Lysosomal Storage Diseases: Mucopolysaccharidosis VII (MPS VII) Role:PI $20,000.00 Active Level:Private Non-Profit

Grant: #Check 1201 Investigators:Kao, Winston Whei Yang 09-01-2018 -08-31-2019 Ohio Lions Eye Research Foundation Effect of Extracellular Matrix Components on Umbilical Cord derived Mesenchymal Stem Cells (UMSCs) Role:PI $31,476.00 Active Level:Private Non-Profit

Grant: #Check 1197 Eye 2018-19 Investigators:Kao, Winston Whei Yang 09-15-2018 -09-14-2019 Ohio Lions Eye Research Foundation Gene and Cell Therapy of Ocular Surface Diseases Role:PI $20,000.00 Awarded Level:Private Non-Profit

Grant: #Check 1206 Adm 2018-19 Investigators:Kao, Winston Whei Yang; Park, Yoonjee 09-15-2018 -09-14-2019 Ohio Lions Eye Research Foundation “On-demand” Long-Term Drug Delivery for Age-Related Macular Degeneration Treatment Role:PI $10,000.00 Awarded Level:Private Non-Profit

Grant: #CRFF-2018-004 Investigators:Amlal, Hassane; Dong, Fei; Kao, Winston Whei Yang 02-01-2019 -01-31-2020 Cystinosis Research Foundation Cell Therapy and Gene Editing for Cystinosis Role:PI $179,834.00 Awarded Level:Private Non-Profit

Publications
Peer Reviewed Publications

Mongan, Maureen; Wang, Jingcai; Liu, Hongshan; Fan, Yunxia; Jin, Chang; Kao, Winston Y-W; Xia, Ying (2011. )Loss of MAP3K1 enhances proliferation and apoptosis during retinal development.Development (Cambridge, England), ,138 (18 ),4001-12

Keywords

Stem Cells,Proteoglycans,Age-related Macular Degeneration,Collagen Biochemistry,Molecular Genetics of Collagen,Prolyl-4 Hydroxylase,Collagen Disease,Fibrosis,Corneal Wound Healing,Expression of Collagen Gene,Embryonic Development,Embryonic Stem Cell,Gene Targeting,Mesenchyme-epithelium Interactions

Research and Practice Interests

Roles of Mesenchyme-Epithelium Interactions on Morphogenesis during Eye Development, And Homeostasis And Wound Healing in Adult Corneas The central hypothesis of our ongoing research is that the mesenchyme-epithelium interactions via signal transduction of growth factors and their receptors play pivotal roles in eye morphogenesis during development and in ocular homeostasis and wound healing in adults. Morphogenesis of cornea, conjunctiva and eyelids during vertebrate eye development involves themigration and differentiation of mesenchymal cells of neural crest origin, and the differentiation of cells of the surface ectoderm. The bi-directional mesenchyme-epithelium interactions via growth factors are essential for morphogenesis during development and homeostasis in adults. Growth factors (e.g., TGF-s and FGF-7) play pivotal roles in modulating functions of mesenchymal cells of neural crest origin and differentiation of ectoderm cells during ocular morphogenesis. Conditional gene ablation in cornea has been achieved by the use of Cre-LoxP system with keratocyte-specific keratocan promoter and modification Krt12 allele via knock-in strategy. Tetracycline inducible mouse lines have been used to overexpress reporter genes in corneas. Development of Gene Therapy Strategy for Treating Ocular Surface Diseases The success of a gene therapy strategy relies on the delivery of reporter gene constructs to target tissues and sustained expression levels of the reporter genes sufficient to revert the pathological processes. Easy access of ocular surface tissues presents itself as an ideal model to examine the efficacy of gene therapy. We recently used Gene Gun, a particle-mediated gene transfer technique, to characterize the promoter of cornea-specific keratin 12 gene. We have also adapted the techniques of expressing reporter genes by injecting plasmid DNA into cornel stroma. The techniques can be potentially used as a mean of gene transfer for ocular surface tissues, e.g., cornea, conjunctiva, eyelid. To examine the efficacy of growth factors, e.g., TGF-s, FGF-7, HGF, etc. in modulating cornea functions, keratin 12 and keratocan promoters will be used to prepare reporter genes of afore mentioned growth factors. Gene gun will be used to deliver the reporter gene to corneal epithelium and their effects on corneal wound healing will be examined. Isolation and Characterization of Limbal Stem Cells Effective gene therapy to treat ocular surface diseases is not yet available. Limbal transplantation is an option of treating many ocular surface diseases. It is known that stem cells of corneal epithelium reside in the basal cell layer of limbus. Thus, the success of limbal transplantation to treat ocular surface diseases may result fromthe restoration of stem cells in the diseased tissues. However, our skill of culturing limbal stem cells is limited. Thus, there is a need to isolate and characterize the epithelial cells that posses characteristics of limbal stem cells, which can be used as un-limited sources for the use as auto graft or allograft to treat patients of limbal deficiency.

Preferred Information

Professor, Kao, Winston Whei Yang PhD

Contact Information

Academic - Stetson Building
Suite 5300
Ohio, 45267
Phone: 513-558-5151
winston.kao@uc.edu

Headshot of Andrei B. Kogan

Andrei B. Kogan

Associate Professor , A&S Physics

422 Geology-Physics Building

513-556-0639

Research Support

Grant: #ECCS-0722619 Investigators:Jackson, Howard; Klotzkin, David; Kogan, Andrei; Mantei, Thomas; Papautsky, Ian; Schulz, Mark; Shanov, Vesselin; Smith, Leigh 08-01-2007 -07-31-2008 National Science Foundation MRI: Acquisition of an Inductively-Coupled Plasma Etch Tool Role:Collaborator $300,000.00 Closed Level:Federal

Grant: #865-Action Fund Investigators:Jackson, Howard; Klotzkin, David; Kogan, Andrei; Mantei, Thomas; Papautsky, Ian; Schulz, Mark; Shanov, Vesselin; Smith, Leigh 08-01-2007 -07-31-2008 Ohio Board of Regents MRI: Acquisition of an Inductively-Coupled Plasma Etch Tool Role:Collaborator $150,000.00 Active Level:State of Ohio

Grant: #DMR-0804199 Investigators:Kogan, Andrei 08-01-2008 -07-31-2012 National Science Foundation Exploring Dynamic Spin Correlations in Nanoscale Structures via Microwave Transport Spectroscopy. Role:PI $330,000.00 Closed Level:Federal

Grant: #ECCS-0922682 Investigators:Ahn, Chong; Boyd, Joseph; Halsall, H Brian; Heikenfeld, Jason; Heineman, William; Jackson, Howard; Kogan, Andrei; Mantei, Thomas; Papautsky, Ian; Schaefer, Dale; Schulz, Mark; Shanov, Vesselin; Smith, Leigh; Yarrison-Rice, Jan 09-01-2009 -08-31-2010 National Science Foundation MRI: Acquisition of a Nanoscale Imprint Lithography System Role:Collaborator $360,468.00 Closed Level:Federal

Grant: #OBR AF925 Investigators:Ahn, Chong; Boyd, Joseph; Halsall, H Brian; Heikenfeld, Jason; Heineman, William; Jackson, Howard; Kogan, Andrei; Mantei, Thomas; Papautsky, Ian; Schaefer, Dale; Schulz, Mark; Shanov, Vesselin; Smith, Leigh; Yarrison-Rice, Jan 09-01-2009 -08-31-2010 Ohio Board of Regents MRI: Acquisition of a Nanoscale Imprint Lithography System Role:Collaborator $180,234.00 Closed Level:State of Ohio

Grant: #DMR-1206784 Investigators:Kogan, Andrei 07-01-2012 -06-30-2015 National Science Foundation Nonadiabatic Transport in Quantum Devices Role:PI $232,000.00 Active Level:Federal

Preferred Information

Associate Professor,

Headshot of Chia-Ying J Lin

Chia-Ying J Lin

Professor and Research Director of Orthopaedic Surgery , COM Orthopaedic Surgery

5452 Medical Sciences Building

513-558-8412

Education

B.S., National Taiwan University Taipei, Taiwan, 1997 (Civil Engineering)

M.S., University of Michigan Ann Arbor, Mich., 2002 (Biomedical Engineering)

Ph.D., University of Michigan Ann Arbor, Mich., 2004 (Biomechanics/Tissue Engineering, Biomedical Engineering)

Research Support

Grant: #R21EB025378 09-25-2017 -07-31-2019 NIH/National Institute of Biomedical Imaging and Bioengineering Development of Hybrid Tracheas for Long-Segment Tracheal Reconstruction Role:PI $446,324.00 Active Type:Grant

Grant: #R01NS103992 NIH/NINDS A novel smart patch for the fetoscopic procedure to repair spina fbifida Role:Co-PI $2,324,878 Pending Type:Grant

Grant: #Center for Technology Commercialization 2017 Innovation Award 09-01-2017 -08-31-2018 Cincinnati Children’s Hospital Medical Center Shape-memory patch for prenatal spina bifida repair by fetoscopic approach Role:Co-PI $100,000 Active Type:Grant

Grant: #Pilot Translational Research and Innovative Core Grant 07-01-2017 -06-30-2018 Center for Clinical & Translation Science & Training (sponsored by NIH Roadmap CTSA) Injectable gel depot of simvastatin beta-hydroxy acid to treat discogenic low back pain - IND enabling phase Role:PI $60,000 Active Type:Grant

Grant: #2017 Angela S.M. Kuo Memorial Award 06-01-2017 -05-31-2019 Pediatric Orthopedic Society of North America A Novel Treatment for Large Osteochondral Defects Role:Co-PI $30,000 Active Type:Grant

05-01-2017 -04-30-2018 Depuy Synthes Incidence of Stress Shielding with the Attune TKA Role:PI $43,974 Active Type:Contract

Grant: #Focused Grant Award 01-01-2017 -12-31-2017 American Sleep Medicine Foundation Custom 3-D Printed Non-invasive Ventilation Mask for Children with Obstructive Sleep Apnea Role:Co-Investigator $20,000 Active Type:Grant

Grant: #Orthopaedic Faculty Grant Investigators:Grawe and Lin 01-01-2017 -12-31-2017 University of Cincinnati Department of Orthopaedic Surgery Simvastatin Acid Used in Meniscal Tear Repair Role:Co-PI $15,000 Active Type:Grant

Grant: #Orthopaedic Faculty Grant Investigators:Archdeacon and Lin 01-01-2017 -12-31-2017 University of Cincinnati Department of Orthopaedic Surgery Application of Ground Penetrating Radar for Pelvic Fracture Detection Role:Co-PI $15,000 Active Type:Grant

Grant: #Technology Accelerator Award Investigators:Lin, Chia-Ying 07-01-2016 -06-30-2017 University of Cincinnati Department of Orthopaedic Surgery Injectable gel depot of simvastatin beta hydroxy acid to treat discogenic low back pain Role:PI $40,000 Completed Type:Grant

Grant: #R01AR060892 Investigators:Hollister, La Marca, and Lin 09-17-2011 -08-31-2017 NIH/NIAMS Integrated Structural BMP-2 Carrier Systems for Cervical Spine Fusio Role:Co-Investigator $2,437,852 Completed Type:Grant

Grant: #University of Cincinnati Cancer Institute Research Pilot Grant Investigators:Czyzyk-Krzeska, Archdeacon, and Lin 08-01-2015 -07-31-2016 University of Cincinnati Cancer Institute Mechanisms of bone metastases in renal cancer Role:Co-PI $40,000 Completed Type:Grant

Grant: #R01AR056649 06-11-2010 -03-31-2015 NIH/NIAMS Simvastatin to Retard Degenerative Disc Disease Role:PI $1,326,998 Completed Type:Grant

Grant: #R21NS055731 05-24-2006 -04-30-2009 NIH/NINDS Designed Degradable Interbody Cages Role:PI $344,512 Completed Type:Grant

Publications
Peer Reviewed Publications

Wang, Lin; Park, Paul; La Marca, Frank; Than, Khoi D; Lin, Chia-Ying (2015. )BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation.Journal of cancer research and clinical oncology, ,141 (6 ),1013-24

Than, Khoi D; Rahman, Shayan U; Wang, Lin; Khan, Adam; Kyere, Kwaku A; Than, Tracey T; Miyata, Yoshinari; Park, Yoon-Shin; La Marca, Frank; Kim, Hyungjin M; Zhang, Huina; Park, Paul; Lin, Chia-Ying (2014. )Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease.The spine journal : official journal of the North American Spine Society, ,14 (6 ),1017-28

Wang, Lin; Park, Paul; La Marca, Frank; Than, Khoi; Rahman, Shayan; Lin, Chia-Ying (2013. )Bone formation induced by BMP-2 in human osteosarcoma cells.International journal of oncology, ,43 (4 ),1095-102

Park, Yoon Shin; David, Allan E; Park, Kyung Min; Lin, Chia-Ying; Than, Khoi D; Lee, Kyuri; Park, Jun Beom; Jo, Inho; Park, Ki Dong; Yang, Victor C (2013. )Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells.The AAPS journal, ,15 (2 ),367-76

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Claeson, Amy; Than, Khoi; Rahman, Shayan; Lin, Chia-Ying (2012. )BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation.International journal of cancer, ,131 (8 ),1941-50

Wang, Lin; Rahman, Shayan; Lin, Chia-Ying; Valdivia, Juan; Than, Khoi; La Marca, Frank; Park, Paul (2012. )A novel murine model of human renal cell carcinoma spinal metastasis.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, ,19 (6 ),881-3

Park, Jun-Beom; Zhang, Huina; Lin, Chia-Ying; Chung, Chong Pyoung; Byun, Youngro; Park, Yoon Shin; Yang, Victor C (2012. )Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors ?.The Journal of surgical research, ,174 (2 ),278-83

Than, Khoi D; Rahman, Shayan U; Vanaman, Monique J; Wang, Anthony C; Lin, Chia-Ying; Zhang, Huina; La Marca, Frank; Park, Paul (2012. )Bone morphogenetic proteins and degenerative disk disease.Neurosurgery, ,70 (4 ),996-1002; discussion

Zhang, Huina; Yang, Sushan; Wang, Lin; Park, Paul; La Marca, Frank; Hollister, Scott J; Lin, Chia-Ying (2011. )Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: laboratory investigation.Journal of neurosurgery. Spine, ,15 (4 ),404-13

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Claeson, Amy; Valdivia, Juan; Lin, Chia-Ying (2011. )BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. Cancer biology & therapy, ,11 (5 ),457-63

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Lin, Chia-Ying (2011. )Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity.International journal of cancer, ,128 (2 ),294-303

Lin, Chia-Ying; Wang, Lin; Than, Khoi; Marca, Frank La; Park, Paul (2010. )Cancer stem cell markers: what is their diagnostic value?.Expert opinion on medical diagnostics, ,4 (6 ),473-81

Zhang, Huina; Migneco, Francesco; Lin, Chia-Ying; Hollister, Scott J (2010. )Chemically-conjugated bone morphogenetic protein-2 on three-dimensional polycaprolactone scaffolds stimulates osteogenic activity in bone marrow stromal cells.Tissue engineering. Part A, ,16 (11 ),3441-8

Kang, Heesuk; Park, Paul; La Marca, Frank; Hollister, Scott J; Lin, Chia-Ying (2010. )Analysis of load sharing on uncovertebral and facet joints at the C5-6 level with implantation of the Bryan, Prestige LP, or ProDisc-C cervical disc prosthesis: an in vivo image-based finite element study.Neurosurgical focus, ,28 (6 ),E9

Thawani, Jayesh P; Wang, Anthony C; Than, Khoi D; Lin, Chia-Ying; La Marca, Frank; Park, Paul (2010. )Bone morphogenetic proteins and cancer: review of the literature.Neurosurgery, ,66 (2 ),233-46; discussion 2

Zhang, Huina; Lin, Chia-Ying; Hollister, Scott J (2009. )The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds.Biomaterials, ,30 (25 ),4063-9

Lin, Chia-Ying; Kang, Heesuk; Rouleau, Jeffrey P; Hollister, Scott J; Marca, Frank La (2009. )Stress analysis of the interface between cervical vertebrae end plates and the Bryan, Prestige LP, and ProDisc-C cervical disc prostheses: an in vivo image-based finite element study.Spine, ,34 (15 ),1554-60

Zhang, Huina; La Marca, Frank; Hollister, Scott J; Goldstein, Steven A; Lin, Chia-Ying (2009. )Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture.Journal of neurosurgery. Spine, ,10 (6 ),522-30

Wang, Lin; Park, Paul; Lin, Chia-Ying (2009. )Characterization of stem cell attributes in human osteosarcoma cell lines.Cancer biology & therapy, ,8 (6 ),543-52

Zhang, Huina; Wang, Lin; Park, Jun Beom; Park, Paul; Yang, Victor C; Hollister, Scott J; La Marca, Frank; Lin, Chia-Ying (2009. )Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury.Arthritis research & therapy, ,11 (6 ),R172

Zhang, Huina; Lin, Chia-Ying (2008. )Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway.Spine, ,33 (16 ),E525-31

Lin, Chia-Ying; Wirtz, Tobias; LaMarca, Frank; Hollister, Scott J (2007. )Structural and mechanical evaluations of a topology optimized titanium interbody fusion cage fabricated by selective laser melting process.Journal of biomedical materials research. Part A, ,83 (2 ),272-9

Lin, Chia-Ying; Schek, Rachel M; Mistry, Amit S; Shi, Xinfeng; Mikos, Antonios G; Krebsbach, Paul H; Hollister, Scott J Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffolds.Tissue engineering, ,11 (9-10 ),1589-98

Hollister, S J; Lin, C Y; Saito, E; Lin, C Y; Schek, R D; Taboas, J M; Williams, J M; Partee, B; Flanagan, C L; Diggs, A; Wilke, E N; Van Lenthe, G H; Müller, R; Wirtz, T; Das, S; Feinberg, S E; Krebsbach, P H (2005. )Engineering craniofacial scaffolds.Orthodontics & craniofacial research, ,8 (3 ),162-73

Lin, Chia-Ying; Hsiao, Chun-Ching; Chen, Po-Quan; Hollister, Scott J (2004. )Interbody fusion cage design using integrated global layout and local microstructure topology optimization. Spine, ,29 (16 ),1747-54

Hollister, Scott J; Lin, Chia-Ying; Lin, Cheng-Yu; Schek, Rachel D; Taboas, Juan M; Flanagan, Colleen L; Saito, Eiji; Williams, Jessica M; Das, Suman; Wirtz, Tobias; Krebsbach, Paul H (2004. )Design and fabrication of scaffolds for anatomic bone reconstruction. The Medical journal of Malaysia, ,59 Suppl B ,131-2

Kang, Heesuk; Hollister, Scott J; La Marca, Frank; Park, Paul; Lin, Chia-Ying (2013. )Porous biodegradable lumbar interbody fusion cage design and fabrication using integrated global-local topology optimization with laser sintering.Journal of biomechanical engineering, ,135 (10 ),101013-8

Huang, Chun-Hsiung; Liau, Jiann-Jong; Ho, Fang-Yuan; Lin, Chia-Yin; Young, Tai-Horng; Cheng, Cheng-Kung (2005. )Polyethylene failure of the patellar component in New Jersey low-contact stress total knee arthroplasties. The Journal of arthroplasty, ,20 (2 ),202-8

Ghosh, Paulomi; Gruber, Stacey M S; Lin, Chia-Ying; Whitlock, Patrick W (2018. )Microspheres containing decellularized cartilage induce chondrogenesis in vitro and remain functional after incorporation within a poly(caprolactone) filament useful for fabricating a 3D scaffold.Biofabrication, ,10 (2 ),025007

Ma, Jun; He, Yunfei; Liu, Xilin; Chen, Weiming; Wang, An; Lin, Chia-Ying; Mo, Xiumei; Ye, Xiaojian (2018. )A novel electrospun-aligned nanoyarn/three-dimensional porous nanofibrous hybrid scaffold for annulus fibrosus tissue engineering.International journal of nanomedicine, ,13 ,1553-1567

Ni, Yikun; Wang, Lizhen; Liu, Xiaoyu; Zhang, Hongquan; Lin, Chia-Ying; Fan, Yubo (2017. )Micro-mechanical properties of different sites on woodpecker's skull.Computer methods in biomechanics and biomedical engineering, ,20 (14 ),1483-1493

Preferred Information

Professor and Research Director of Orthopaedic Surgery, Lin, Chia-Ying PhD http://ceas.uc.edu/steel.html

Contact Information

Academic - 5452 Medical Sciences Building
231 Albert Sabin Way
Ohio, 45267-0212
Phone: (513)558-8412
Fax: (513)558-2220
chia-ying.lin@uc.edu

Headshot of Daria Narmoneva

Daria Narmoneva

Associate Professor , CEAS - Biomedical Eng

850 Engineering Research Cntr

513-556-3997

Chronic diabetic ulcers are the leading cause of non-traumatic limb amputations in the US and are a significant health care burden. To improve healing of chronic diabetic wounds, we created a unique microenvironment using a novel hydrogel (based on self-assembling peptide nanofibers) that mimics the native matrix in the wound and promotes healing. To activate unresponsive, diseased cells within the chronic wound, we have developed an electric field-based technology that uses high-frequency wireless electric fields stimulation to activate capillary cells and enhance blood vessel formation in the wound, which results in much faster healing. This technology has been successfully tested in the mouse and pig models, and is under active translational development in collaboration with UCRI and the UC Office for Entrepreneurial Affairs and Technology Commercialization.
Education

Postdoctoral Training, Brigham & Women’s Hospital, Harvard Medical School, Division of Cardiovascular Research Boston, MA, 06-2004 (Cardiac tissue engineering)

Postdoctoral Training, Massachusetts Institute of Technology Cambridge, MA, 01-2001 (Development of novel angiogenic scaffold)

Postdoctoral Training, Massachusetts General Hospital, Department of Vascular Surgery Boston, MA, 12-2001 (Effects of shear stress on arteriogenesis)

Ph.D. in Biomedical Engineering, Duke University Durham, NC, 12-2000 (Material Property Determination for Normal and Osteoarthritic Articular Cartilage Using a Triphasic Mechano-Chemical Theoretical Model of Osmotic Loading)

M.S. in Condensed Matter and Low Temperature Physics, Moscow Institute of Physics and Technology Moscow, Russia, 06-1993 (Phonon Interaction with Aluminum Single Crystal in Superconducting and Normal States)

Research Support

Investigators:University of Cincinnati 03-2005 -08-2009 Startup funds from the Department of Biomedical Engineering $150,000

Grant: #0765425B Investigators:Narmoneva 07-01-2007 -02-28-2010 American Heart Association Beginning-Grant-in-Aid Endothelial-Fibroblasts Interactions In Vascular Tissue Engineering. NOTE: this is a career-type award for young investigators and is not eligible for renewal $121,000

Investigators:Kogan, Physics, co-PI: Narmoneva, BME 01-01-2009 -12-31-2009 The Institute for Nanoscale science and Technology $22,000

01-01-2009 -12-01-2009 University of Cincinnati Rindsberg Memorial Fund Fellowship Award for Swathi Balaji $10,000

Investigators:Dr. Joel Fried 06-01-2002 -05-31-2009 Bioapplications of Membrane Science and Technology NSF IGERT predoctoral research traineeship for Jennifer Hurley $135,000

Investigators:Narmoneva 08-01-2002 -07-31-2004 American Heart Association Research Fellowship $66,000

Grant: #NIH/NIDDK 1R21DK078814-01A1 Investigators:Narmoneva 07-15-2008 -06-30-2011 $440,458 Subcontract to Children’s $63,554

Grant: #NIH/NIDDK ARRA 3R21DK078814-01A1S1 Investigators:Narmoneva 06-20-2009 -09-10-2010 $19,556

Grant: #0815371D 07-01-2008 -06-30-2010 Narmoneva American Heart Association predoctoral fellowship for Swathi Balaji $42,000

Grant: #GRA09PRE2150073 07-01-2009 -06-30-2011 Narmoneva American Heart Association predoctoral fellowship for Jennifer Hurley

Grant: #09PRE2230162 07-01-2009 -06-30-2011 Hinton, co-Mentor: Narmoneva American Heart Association predoctoral fellowship for Varun Krishnamurthy $42,000

Narmoneva National Science Foundation $400,000

Grant: #NIH/NIBIB RO1 Investigators:Narmoneva $ 1,563,684

Grant: #NIH/NIBIB RO1 Investigators:Mast, co-investigator: Narmoneva, 5% effort $1,160,517

Grant: #AHA 0765425B Investigators:Narmoneva, Daria 07-01-2007 -02-28-2010 American Heart Association - Great Rivers Affiliate Endothelial-Fibroblast Interactions in Vascular Tissue Engineering Role:PI $121,000.00 Closed Level:Private Non-Profit

Grant: #8081128D Investigators:Balaji, Swathi; Narmoneva, Daria 07-01-2008 -06-30-2010 American Heart Association - Great Rivers Affiliate Angiogenic Microenvironment to Augment Diabetes-Associated Deficiency in Vascularization in the db/db Mouse Model Role:Collaborator $42,200.00 Closed Level:Private Non-Profit

Grant: #R21 DK078814 Investigators:Narmoneva, Daria 07-15-2008 -06-30-2012 National Inst of Diabetes and Digestive and Kidney Disease Angiogenic Peptide Scaffolds to Enhance Diabetic Wound Healing Role:PI $440,458.00 Active Level:Federal

Grant: #3 R21 DK078814-01A1S1 Investigators:Narmoneva, Daria 06-23-2009 -12-31-2010 National Inst of Diabetes and Digestive and Kidney Disease Angiogenic Peptide Scaffolds to Enhance Diabetic Wound Healing Role:PI $19,556.00 Active Level:Federal

Grant: #09PRE2150073 Investigators:Hurley, Jennifer; Narmoneva, Daria 07-01-2009 -06-30-2011 American Heart Association - National Chapter Development of MMP-2/Peptide Nanoscaffold Delivery System for Treatment of Diabetic Cardiomyopathy Role:Collaborator $46,000.00 Closed Level:Private Non-Profit

Grant: #11PRE7420008 Investigators:Cho, Hongkwan; Narmoneva, Daria 07-01-2011 -06-30-2012 American Heart Association - Great Rivers Affiliate Mechanistic Studies of Increased Neovascularization in the Murine Diabetic Wound Treated with Peptide Nanofibers Role:Collaborator $23,000.00 Closed Level:Private Non-Profit

Grant: #R01HL087861 Investigators:Fan, Guochang; Narmoneva, Daria 07-01-2013 -06-30-2018 National Heart, Lung and Blood Institute Roles of Hsp20-Exosomes in Myocardial Angiogenesis Role:Collaborator $393,270.00 Active Level:Federal

Investigators:Co-Investigator: Dr. Andrei Kogan, Physics Department, CA&S, UC 08-01-2016 -08-31-2017 State of Ohio & University of Cincinnati Technology Commercialization Accelerator An Innovative Approach for Non-invasive Wound Healing Therapy Role:PI

07-01-2014 -06-30-2019 National Science Foundation S-STEM: Bridging Our Students to Their Future Role:Co-PI (PI: Dr. Anant Kukreti)

Grant: #NIH 2R01HL087861 Investigators:PI: Guo-Chang Fan, Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 07-26-2013 -06-30-2018 National Institutes of Health Roles of HSP20-exosomes in myocardial angiogenesis Role:Co-Investigator

Investigators:PI: Dr. Jo El Schulz, Dept. of Cell Biophysics, UC COM 07-01-2016 -06-30-2017 UC Heart, Lung and Vascular Institute: New Horizons Seed grant Angiogenesis and arteriogenesis capacity of the FGF2 HMW isoforms in ischemic disease. Role:Co-Investigator

Investigators:Co-investigator: Dr. YiGang Wang, Dept. of Pathology, UC COM 07-01-2014 -06-30-2016 UC Heart, Lung and Vascular Institute: Seed grant Bioengineering Microenvironment for Myocardial Regeneration and Diabetic Cardiomyopathy Role:PI

09-01-2015 -08-31-2016 University of Cincinnati NSF ADVANCE IT, “UC LEAF” (Leadership, Empowerment, Advancement for Women in Stem Faculty) Participation in Leadership development program Role:PI

Investigators:Collaboration with: Dr. Mike Davis, Principal Scientist at P&G 01-25-2015 -02-12-2016 The Procter & Gamble Company, Hair Biology Group, Beauty Technology Division A novel 3D system for hair growth and regeneration Role:PI

01-01-2014 -12-31-2015 University of Cincinnati NSF ADVANCE IT, “UC LEAF” seed award (Leadership, Empowerment, Advancement for Women in Stem Faculty) Cardiac Cell Interactions In Diabetes: A Pilot Study

Investigators:Dale Schaefer – Co-PI 01-01-2014 -12-31-2014 University of Cincinnati BCEE Seed Grant A Cell-Sheet Approach to Wound Healing Role:PI

Grant: #11PRE7420008 Investigators:predoctoral fellowship for Hongkwan Cho; Sponsor: Narmoneva 07-01-2011 -06-30-2012 American Heart Association Mechanistic studies of increased neovascularization in the murine diabetic wound treated with peptide nanofibers

Investigators:Co-Investigators: Kogan, Crombleholme 07-01-2011 -12-31-2012 University Research Council Interdisciplinary Faculty Research Support Grant Low-intensity electromagnetic field for wound healing therapy Role:PI

Grant: #09PRE2230162 Investigators:predoctoral fellowship for Varun Krishnamurthy; Sponsor: Hinton, co-Mentor: Narmoneva) 07-01-2009 -06-30-2012 American Heart Association Elastin haploinsufficiency as a model of progressive aortic valve disease

Investigators:PI: Kogan, Physics, co-PI: Narmoneva, BME 01-01-2009 -12-31-2009 The Institute for Nanoscale science and Technology, University of Cincinnati Effects of high-frequency electromagnetic fields on capillary cell-cell communication Role:Co-PI

Grant: #GRA09PRE2150073 Investigators:predoctoral fellowship for Jennifer Hurley; Sponsor: Narmoneva 07-01-2009 -06-30-2011 American Heart Association Peptide nanoscaffold for MMP delivery and cardiac remodeling in diabetic cardiomyopathy

Grant: #3R21DK078814-01A1S1 06-20-2009 -09-10-2010 National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, American Recovery & Reinvestment Act Angiogenic Peptide Scaffolds to Enhance Diabetic Wound Healing Role:PI

Grant: #0815371D Investigators:predoctoral fellowship for Swathi Balaji; Sponsor: Narmoneva 07-01-2008 -06-30-2010 American Heart Association Angiogenic microenvironment to augment diabetes-associated deficiency in vascularization in the db/db mouse model

Grant: #1R21DK078814-01A1 Investigators:Narmoneva, co-investigator: Dr. Timothy Crombleholme, CCHMC 07-15-2008 -06-30-2012 National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases Angiogenic Peptide Scaffolds to Enhance Diabetic Wound Healing Role:PI

Grant: #0765425B Investigators:Endothelial-Fibroblasts Interactions In Vascular Tissue Engineering 07-01-2007 -02-28-2010 American Heart Association Beginning-Grant-in-Aid Role:PI

08-01-2002 -07-31-2004 American Heart Association Research Fellowship A new three-dimensional culture system for in vitro angiogenesis and cardiac tissue engineering Role:PI

Publications
Peer Reviewed Publications

Hurley JR, Balaji S, Sheikh AQ, Cho H, Crombleholme TM, Narmoneva DA Diabetes-impaired angiogenic potential of endothelial cells is restored by angiogenic microenvironment .

S. Balaji, King BA, Herbig BA, Crombleholme TM, and Narmoneva DA Improved wound healing in angiogenic provisional matrix occurs with limited TGF-b and myo-fibroblast contribution .

Cho H, Sheikh AQ, Narmoneva DA Peptide nanofibers mediate angiogenesis via non-specific interactions with endothelial cells .

Sheikh AQ, Kogan AB, Narmoneva DA Frequency-dependent electromagnetic field regulation of angiogenesis and MAPK/MEK signaling .

Balaji S, Vaikunth SS, Sheikh AQ, Lim FY, Crombleholme TM, Narmoneva DA Tissue engineered provisional matrix as a novel approach to enhance diabetic wound healing .

Wang Y, Xiang J, Vannest J, Holroyd T, Narmoneva DA, Horn P, Liu Y, Rose D, Ton deGrauw2, Holland S Electromagnetic fields induced by word processing in Bilinguals and Monolinguals .Clinical Neurophysiology, ,

Krishnamurthy VK, Guilak F, Narmoneva DA, Hinton RB (01-04-2011. )Regional structure-function relationships in mouse aortic valve tissue .J Biomech., ,44 (1 ),77-83

Hinton RB, Adelman-Brown J, Witt S, Krishnamurthy VK, Gruber MJ, Osinska H, Sakthivel B, Narmoneva DA, Mecham RP, Benson DW (08-20-2010. )Elastin Haploinsufficiency Results in Latent Progressive Aortic Valve Disease in a Mouse Model .Circulation Research., ,107 (4 ),549-557

Hurley JR, Balaji S, Narmoneva DA (08-2010. )Complex temporal regulation of capillary morphogenesis by fibroblasts .American Journal of Physiology: Cell Physiology., ,299 (2 ),C444-453

Balaji S, King BA, Sheikh AQ, Cho H, Bloomer M, Lim FY, Crombleholme TM, Narmoneva DA (2010. )Improved wound healing in angiogenic provisional matrix occurs in the absence of increased TGF-beta expression .Wound Repair and Regeneration , ,18 (2 ),A22

Cho H, Balaji S, Sheikh AQ, Bloomer M, King BA, Lim FY, Crombleholme TM, Narmoneva DA (2010. )Pro-angiogenic microenvironment restores angiogenic potential of diabetic endothelial cells .Wound Repair and Regeneration, ,18 (2 ),A22

Cho H, Sheikh AQ, Narmoneva DA (2010. )Non-specific endothelial cell interactions with the substrate result in cell activation and angiogenesis in vitro .Proceedings of the ASME Summer Bioengineering Conference, ,

Balaji S, Sheikh AQ, Vaikunth SS, Parvadia JK, Lim FY, Crombleholme TM, Narmoneva DA (2009. )Wound treatment with angiogenic provisional matrix enhances wound neovascularization and improves healing in db/db mice .Wound Repair and Regeneration, ,17 (2 ),A15

Sheikh AQ, Kogan AB, Narmoneva DA (2009. )Electromagnetic field mediates capillary-like network formation va MAPK/ERK sgnaling cascade .Proceedings of the ASME Summer Bioengineering Conference , ,SBC2009 (PART B) ,853-854

Balaji S, Sheikh AQ, Morris L, Lim FY, Crombleholme TM, Narmoneva DA (2009. )Angiogenic nanoscaffold accelerates diabetic wound healing and improves wound tissue strength in DB/DB mice .Proceedings of the ASME Summer Bioengineering Conference , ,SBC2009 (PART B) ,1173-1174

Hurley JR, Narmoneva DA (2009. )Endothelial-fibroblast interactions in angiogenesis and matrix remodeling .Proceedings of the ASME Summer Bioengineering Conference , ,SBC2009 (PART A) ,413-414

Gruber M., Krishnamurthy V., Narmoneva DA, Hinton Jr RB (2008. )Elastin haploinsufficiency results in progressive aortopathy and altered interstitial cell phenotype .Proceedings of the ASME summer bioengineering conference , ,501-502

Hurley JR, Balaji S, Narmoneva DA (2008. )Fibroblasts induce mechanical changes in the extracellular environment and enhance capillary-like network formation .Proceedings of the ASME summer bioengineering conference , ,641-642

Balaji S, Parvadia J, Vaikunth SS, Crombleholme TC, and Narmoneva DA (2008. )In situ tissue engineering using angiogenic nanoscaffold enhances diabetic wound healing in db/db mouse model .Proceedings of the ASME summer bioengineering conference , ,223-224

Vaikunth SS, Balaji S, Maldonado A, Parvadia J, Lim FY, Crombleholme TM, Narmoneva DA (2007. )In situ tissue engineering using self-assembling peptide improves wound healing and neovascularization in a diabetic mouse model .Wound Repair and Regeneration, ,15 (2 ),A43

Balaji S, Marcotte KE, R. Helton, and Narmoneva DA (2006. )Novel peptide scaffold promotes cell migration and angiogenesis through enhanced expression of angiogenic factors .Thrombosis and Haemostasis, ,4 (Suppl I ),69

Narmoneva DA, Oni O, Sieminsky A, Zhang S, Gertler JP, Kamm RD, and Lee RT (08-2005. )Self-Assembling Peptides as a Novel Biomaterial for Promoting Angiogenesis .Biomaterials., ,26 (23 ),4837-4846

Hsieh PCH, Resta LP, Davis ME, Narmoneva DA, and Lee RT (2005. )Cardiomyocyte-endothelial interactions in cardiac regeneration .Nova Acta Leopoldina, ,NF 92 (343 ),61-72

Davis ME, Motion JP, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, Zhang S, Lee RT (2005. )Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for en-dothelial cells .Circulation., ,111 (4 ),442-450

Narmoneva DA, Vukmirovic R, Davis ME, Kamm RD, and Lee RT (08-2004. )Endothelial Cells Promote Cardiac Myocyte Survival and Spatial Reorganization: Implications for Cardiac Regeneration .Circulation., ,110 (8 ),962-968

Narmoneva DA, Vukmirovic R, Davis ME, Kamm RD, and Lee RT (2003. ): Endothelial cells promote cardiac myocyte survival and spatial reorganization in engineered cardiac tissue .Circulation, ,108 (17 ),165-165

Narmoneva DA, Howell DS, Cheung HS, Wang JY and Setton LA (2002. )Altered swelling behavior of femoral cartilage following joint immobilization in a canine mode .Journal of Orthopaedic Research, ,20 (1 ),83-91

Elliott DM, Narmoneva DA and Setton LA (2002. )Direct measurement of the Poisson’s ratio of human patellar cartilage in tension .Journal of Biomechanical Engineering, ,124 (2 ),223-228

Flahiff CM, Narmoneva DA, Huebner JL, Kraus VB, Guilak F, and Setton LA (09-2002. )Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage .Journal of Biomechanics., ,35 (9 ),1285-1290

Narmoneva DA, Wang JY and Setton LA (2001. )A non-contacting method for material property determination for articular cartilage from osmotic loading .Biophysical Journal , ,81 (6 ),3066-3076

Narmoneva DA, Wang JY and Setton LA (1999. )A new method for determination of the tensile modulus of articular cartilage in situ in a free swelling configuration .ASME Advances in Bioengineering, ,43 ,31-32

Narmoneva DA, Wang JY and Setton LA (1999. )Nonuniform swelling-induced residual strains in articular cartilage .Journal of Biomechanics, ,41 ,401-408

Narmoneva DA, Wang JY, Patel SS, Howell DS, and Setton LA (1997. )Altered swelling–induced strain fields in articular cartilage following periods of immobilization .ASME Advances in Bioengineering, ,36 ,125-126

Zinov’eva KN, DA Narmoneva and AS Semenov (1994. )Effect of the transition from the normal state to the superconducting state on the phonon transmission through liquid 4 He-metal interface .Letters to the Journal of the Experimental and Theoretical Physics , ,59 (2 ),124-129

Zinov’eva KN, DA Narmoneva and AS Semenov (1994. )Resonant acoustic modes at a liquid 4 He–copper interface .Journal of the Experimental and Theoretical Physics, ,78 (5 ),690-705

Zinov’eva KN, DA Narmoneva and AS Semenov (1993. )Interaction of acoustic waves with metal crystal surfaces .Springer Series in Solid-State Sciences, ,VII ,385

Angel PM, Narmoneva DA, Sewell-Loftin MK, Munjal C, Dupuis L, Landis BJ, Jegga A, Kern CB, Merryman WD, Baldwin HS, Bressan GM, Hinton RB (2017. )Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.Ann Biomed Eng., ,45 (11 ),2548 -2562

Knorr JM, Jackson J, Batie MR, Narmoneva DA, Jones DC (2016. )Application of strain and calibration of FRET emission for in vitro live cell response to cytoskeletal deformation.J Biomechanics, ,

Cho H, Balaji S, Hone NL, Moles CM, Sheikh AQ, Crombleholme TM, Keswani SG, Narmoneva DA (2016. )Diabetic wound healing in a MMP9-/- mouse model.Wound Repair Regen., ,

McWhorter ED, Huang W, Stumpf E, Tolpadi A, Narmoneva DA, Wang Y In situ microenvironment for diabetic myocardium repair following injury .Wound Repair Regen., ,24 (2 ),

Zafar F, Hinton RB, Moore RA, Baker RS, Bryant R 3rd, Narmoneva DA, Taylor MD, Morales DL (2015. )Physiological Growth, Remodeling Potential, and Preserved Function of a Novel Bioprosthetic Tricuspid Valve: Tubular Bioprosthesis Made of Small Intestinal Submucosa-Derived Extracellular Matrix.J Am Coll Cardiol, ,66 (8 ),877-888

Taghian, T; Sheikh, AQ; Cho, H; Kogan, AB; Narmoneva, DA (2015. )A novel contact electric field therapy to enhance angiogenesis and wound healing .Wound Repair Regen., ,23 (2 ),

Krishnamurthy VK, Godby RC, Liu GR, Smith JM, Hiratzka LF, Narmoneva DA, Hinton RB (2015. )Review of Molecular and Mechanical Interactions in the Aortic Valve and Aorta: Implications for the Shared Pathogenesis of Aortic Valve Disease and Aortopathy .J Cardiovasc Transl Res., ,

Krishnamurthy VK, Evans AN, Wansapura JP, Osinska H, Maddy KE, Biechler SV, Narmoneva DA, Goodwin RL, Hinton RB (2014. )Asymmetric cell-matrix and biomechanical abnormalities in elastin insufficiency induced aortopathy .Ann Biomed Eng., ,42 (10 ),2014-2028

Taghian T, Sheikh AQ, Kogan AB, Narmoneva DA (2014. )Harnessing Electricity in Biosystems - A Functional Tool for Tissue Engineering Applications .Austin Journal of Biomedical Engineering, ,1 (5 ),

Sheikh AQ, Kuesel C, Taghian T, Hurley JR, Huang W, Wang Y, Hinton RB, Narmoneva DA (2014. )Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions .American Journal of Physiology – Cell Physiology, ,306 (8 ),768-778

Hurley JR, Cho H, Sheikh AQ, Balaji S, Keswani SG, Crombleholme TM, Narmoneva DA (2014. )Nanofiber Microenvironment Effectively Restores Angiogenic Potential of Diabetic Endothelial Cells .Advances in Wound Care, ,3 (11 ),717-728

Yao J, Liu GR, Narmoneva DA., Hinton RB, Zhang Z-Q (2013. )Immersed smoothed finite element method for fluid-structure interaction simulation of aortic valves .Computational Mechanics, ,20 (6 ),789-804

Sheikh AQ, Taghian T, Hemingway B, Cho H, Kogan AB, Narmoneva DA (2013. )Regulation of endothelial MAPK/ERK signaling and capillary morphogenesis by low amplitude electric field.Journal of the Royal Society Interface, ,10 (78 ),

Sheikh AQ, Hurley J, Huang W, Taghian T, Cho H, Kogan AB, Wang Y, Narmoneva D (2012. )Diabetes alters intracellular calcium transients in cardiac endothelial cells .PLoS One, ,7 (5 ),

Hurley JR, Sheikh AQ, Huang W, Wang Y, Narmoneva DA (2012. )Effects of diabetes on matrix protein expression and response to cyclic strain by cardiac fibroblasts .Cellular and Molecular Bioengineering, ,5 (2 ),173-183

Hurley JR, Sheikh AQ, Huang W, Wang Y, Narmoneva DA (2012. )Self-assembling peptide nanofibers for MMP delivery and cardiac regeneration in diabetes.Journal of Bioengineering and Biomedical Sciences, ,

Krishnamurthy VK, Opoka AM, Kern CB, Guilak F, Narmoneva DA, Hinton RB (2012. )Maladaptive Matrix Remodeling and Regional Biomechanical Dysfunction in a Mouse Model of Aortic Valve Disease .Matrix Biology, ,31 (3 ),197-205

Cho H, Balaji S, Sheikh AQ, Hurley JR, Tian YF, Collier JH, Crombleholme TM, Narmoneva DA (2012. )Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers .Acta Biomaterialia, ,8 ,154-164

Balaji S, Vaikunth SS, Lang SA, Sheikh AQ, Lim FY, Crombleholme TM, Narmoneva DA (2012. )Tissue engineered provisional matrix as a novel approach to enhance diabetic wound healing .Wound Repair and Regeneration, ,20 (1 ),15-27

Karunakaran CP, SM Rudich, A Alqadah, MT Burgess, DA Narmoneva, DT Mast (2012. )Histologic analysis of rabbit liver cancer treated by bulk ultrasound ablation .AIP Proceedings , ,10 ,162-168

Wang Y, Xiang J, Vannest J, Holroyd T, Narmoneva DA, Horn P, Liu Y, Rose D, Ton deGrauw, Holland S (2011. )Electromagnetic fields induced by word processing in Bilinguals and Monolinguals .Clinical Neurophysiology, ,122 (9 ),1706-1717

Krishnamurthy VK, Guilak F, Narmoneva DA, Hinton RB (2011. )Regional structure-function relationships in mouse aortic valve tissue .Journal of Biomechanics, ,44 (1 ),77-83

Taghian T, Narmoneva DA, Kogan AB (2015. )Modulation of cell function by electric field: a high-resolution analysis.J R Soc Interface, ,6 (12 ),

Other Publications

Johnson JD, Privitera MB, Narmoneva DA, and Haridas B (2008. )Design and Experimental Capstone: An Integrated Experience .Proceedings of the Annual meeting of the American Society for Engineering Education, 74008 ,

Presentations
Invited Presentations

Daria A. Narmoneva (04-2011. )Endothelial cell as a universal sensor .to be given at the Department of Biomedical Engineering, University of Pennsilvania.

Daria A. Narmoneva (04-2010. )Electromagentic field as a regulator of MAPK/ERK pathway in angiogenesis .Vascular Club, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Daria A. Narmoneva (02-2010. )Regulation of angiogenesis by extracellular microenvironment .University of Cincinnati College of Medicine, Department of Molecular and Cellular Physiology, Cincinnati, OH.

Daria A. Narmoneva (09-2008. )Cell-Cell & Cell-Matrix Interactions In Vascular Tissue Engineering .Cincinnati Children’s Hospital Research Foundation, Department of Pediatrics and Pulmonary Biology, Cincinnati, OH.

Daria A. Narmoneva (11-2007. )Vascular Tissue Engineering Using Self-Assembling Peptide Nanoscaffold .University of Cincinnati College of Medicine, Division: Nephrology & Hypertension, Cincinnati, OH.

Daria A. Narmoneva (08-2007. )Endothelial cell – fibroblast interactions in vascular tissue engineering .Vascular Club, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Daria A. Narmoneva (06-2004. )Self-Assembling peptide nanoscaffolds: a novel system for angiogenesis and vascular tissue engineering .Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH.

Daria A. Narmoneva (02-2002. )A novel culture system for in vitro angiogenesis and tissue engineering .Cardiovascular Division Work-In-Progress Research Seminar, Brigham & Women’s Hospital, Harvard Medical School,

Daria A. Narmoneva (02-2001. )A non-contacting method for material property determination for articular cartilage from osmotic loading .Seminar Series in Fluid Mechanics, Massachusetts Institute of Technology,

Daria A. Narmoneva (05-2000. )Osteoarthritis-related alterations in cartilage structure and mechanical properties detected using a novel osmotic-loading technique .Molecular cell bioengineering laboratory, Massachusetts Institute of Technology,

Daria A. Narmoneva (03-1997. )Nonuniform swelling strains in full-thickness articular cartilage .Seminars in Cellular and Biosurface Engineering, Duke University,

Poster Presentations

Sheikh AQ, Nolan K, Cho H, Balaji S, Bloomer M, Narmoneva DA (10-2010. )Diabetes-associated endothelial deficiency is improved by pro-angiogenic microenvironment .Accepted for presentation at the Biomedical Engineering Society annual meeting,

Krishnamurthy VK, Adelman-Brown J, Nielsen R, Guilak F, Narmoneva DA, Hinton RB (2010. )Regional Aortic Valve Biomechanics in a Mouse Model of Aortic Valve Disease .4th Biennial Heart Valve Biology and Tissue Engineering Meeting, Hilton Head Island, South Carolina. .

Sheikh AQ, Kogan AB, Narmoneva DA (10-2009. )Nanosecond electromagnetic field mediates capillary-like network formation via MAPK/ERK pathway .Transactions of the Biomedical Engineering Society,

Hurley JR, Balaji S, King B, Nolan K, Jiang S, Haider KH, Wang Y, Ashraf M, Narmoneva DA (10-2009. )Self-assembling peptide nanoscaffold for MMP delivery and cardiac regeneration in the diabetic heart .Transactions of the Biomedical Engineering Society,

Cho H, Sheikh AQ, Narmoneva DA (10-2009. )Peptide nanoscaffold mediates angiogenesis via non-specific interactions with endothelial cells .Transactions of the Biomedical Engineering Society,

Krishnamurthy VK, Johnson A, Guilak F, Narmoneva DA, Hinton RB (10-2009. )Micorpipette aspiration as a nove approch for biomechanical testing of heart valve tissue .Transactions of the Biomedical Engineering Society,

Hurley JR, Balaji S, Narmoneva DA (2009. )Dual role of fibroblasts as mediators of angiogenesis in the peptide nanoscaffold microenvironment .Transactions of the International Society for Heart Research , Baltimore, MD. .

Hurley JR, Balaji S, King B, Nolan K, Jiang S, Haider KH, Ashraf M, Narmoneva DA (04-2009. )Peptide Nanoscaffold for MMP Delivery and Cardiac Remodeling in Diabetic Cardiomyopathy .Midwest Tissue Engineering Consortium, Pittsburgh, PA. .

Cho H, Sheikh QA, Narmoneva DA (2009. )The RAD16-II Peptide Nanoscaffold Enhances Capillary-Like Network Formation By Non-Specific Interactions With Endothelial Cells .Midwest Tissue Engineering Consortium, Pittsburgh, PA. .

S. Balaji, A.Q. Sheikh, L. Morris, F.Y. Lim, T.M. Crombleholme, and D.A. Narmoneva (04-2009. )Angiogenic nanoscaffold enhances neovascularization and improves wound healing and repair tissue strength in db/db mice .Midwest Tissue Engineering Consortium, Pittusburg, PA. .

Hurley JR, Narmoneva DA (04-2009. )Matrix Remodeling by Fibroblasts Supports Angiogenesis in the Peptide Nanoscaffold Microenvironment .Midwest Tissue Engineering Consortium, Pittsburgh, PA. .

Zimnicki T, Narmoneva DA (11-2008. )Fibroblast Cells Promote Capillary-Like Network Formation by Endothelial Cells via Vascular Endothelial Growth Factor-Dependent Mechanism .19TH Annual Argonne symposium for undergraduates in science, engineering and mathematics, Argonne National Laboratory, Argonne, IL. .

Sheikh A, Kogan AB, Narmoneva DA (10-2008. )Electromagnetic field stimulation of capillary assembly in RAD16 nanoscaffold for angiogenic therapy .Transactions of the Biomedical Engineering Society,

Hurley J, Zimnicki T, Narmoneva DA (10-2008. )Regulation of angiogenesis via fibroblast-mediated matrix remodeling .Transactions of the Biomedical Engineering Society,

Krishnamurthy V., Gruber M., Narmoneva DA, Hinton Jr RB (11-2008. )Elastin haploinsufficiency leads to altered interstitial cell phenotype and progressive aortopathy .Transactions of the Biomedical Engineering Society,

Balaji S, Parvadia J, Vaikunth SS, Lim FY, Crombleholme TC, and Narmoneva DA (04-2008. )Peptide nanoscaffold treatment enhances endothelial and progenitor cell recruitment and improves wound healing in db/db mice .Symposium on the Advanced Wound Care,

Johnson JD, Privitera MB, Narmoneva DA, and Haridas B (2008. )Design and Experimental Capstone: An Integrated Experience .Proceedings of the Annual meeting of the American Society for Engineering Education,

Gruber M., Krishnamurthy V., Narmoneva DA, Hinton Jr RB (04-2008. )Elastin haploinsufficiency is associated with altered interstitial cell phenotype and progressive aortopathy .Midwest Tissue Engineering Consortium, Cincinnati, OH. .

Hurley JR, Marcotte KE, Narmoneva DA (04-2008. )Fibroblasts Regulate the Extracellular Mechanical Environment and In Vitro Capillary-Like Network Formation .Midwest Tissue Engineering Consortium, Cincinnati, OH. .

Balaji S, Parvadia J, Vaikunth SS, Lim FY, Crombleholme TM, Narmoneva DA (04-2008. )In Situ Tissue Engineering Improves Neovascularization And Wound Healing In Db/Db Mice .Midwest Tissue Engineering Consortium, Cincinnati, OH. .

Sheikh A, Kogan AB, Narmoneva DA (04-2008. )Microwave field enhances capillary-like network assembly by microvascular endothelial cells .Midwest Tissue Engineering Consortium, Cincinnati, OH. .

Hurley JR, Balaji S, Marcotte KE, Narmoneva DA (09-2007. )Fibroblasts Facilitate In Vitro Angiogenesis via Regulation of Chemical and Mechanical Environments .Transactions of the Biomedical Engineering Society,

Balaji S, Parvadia J, Vaikunth SS, Crombleholme TM, Narmoneva DA (09-2007. )Angiogenic scaffold promotes neovascularization and wound healing in murine model of type II diabetes .Transactions of the Biomedical Engineering Society,

Balaji S, Vaikunth SS, Maldonado AM, Parvadia J, Lim FY, Crombleholme TM, Narmoneva DA (04-2007. )Angiogenic Scaffold Enhances Wound Healing In Murine Model of Type II Diabetes .Midwest Tissue Engineering Consortium, Ann Arbor, MI. .

Marcotte KE, Balaji S and Narmoneva DA (08-2006. )Peptide scaffold promotes endothelial cell-fibroblast interactions and angiogenesis in vitro .Transactions of the Biomedical Engineering Society,

Harmon M, Narmoneva DA (08-2005. )Effects of Scaffold Mechanical Properties on Endothelial Cell Network Formation .Surfaces in Biomaterials regional conference, Minneapolis. .

Narmoneva DA, Lee RT and Kamm RD (08-2004. )Effect of scaffold material properties on capillary formation by human endothelial cells .Transactions of the Biomedical Engineering Society,

Narmoneva DA, Lee RT, Gertler JG, and Kamm RD (2002. )Self-assembling peptide scaffold promotes angiogenesis and network formation in three-dimensional culture of human microvascular endothelial cells .Transactions of the International Society of Biomechanics XVIII Congress, Calgary, Canada. .

Flahiff CM, Narmoneva DA, Kraus VB, Huebner JL, Wang JY, Guilak F, Setton LA (2001. )Cartilage mechanics in the guinea pig model of osteoarthritis .Transactions of the Orthopaedic Research Society,

Narmoneva DA, Wang JY and Setton LA (2000. )An inhomogeneous model describes the nonuniform swelling behaviors of human patellar cartilage .Transactions of the Orthopaedic Research Society 25:882,

Leddy HA, Narmoneva DA, Kraus VN, Huebner JL, Guilak F, Wang JY and Setton LA (2000. )Quantitative swelling for material property determinations in guinea pig cartilage .Transactions of the Orthopaedic Research Society 25:108,

Setton LA, Narmoneva DA, Leddy H, Guilak F and Kraus VB (1999. )Quantitative swelling for cartilage property determinations in small animal joints .Transactions of the International Society of Biomechanics XVII Congress,

Narmoneva DA, Guilak F, Vail TP, and Setton LA (1998. )Quantitation of swelling effects in articular cartilage following meniscectomy in a canine model .Transactions of the Orthopaedic Research Society 23:480,

Narmoneva DA and Setton LA (1997. )Measurement of nonuniform swelling strains in full–thickness articular cartilage .Transactions of the Orthopaedic Research Society 22:81,

Honors and Awards

2007 -2010 Who’s Who in Science and Engineering

08-2010 Mentor Recognition Award NSF Research Experience for Undergraduates program, University of Cincinnati

08-2008 Mentor Recognition Award NSF Research Experience for Undergraduates program, University of Cincinnati

08-2007 Mentor Recognition Award NSF Research Experience for Undergraduates program, University of Cincinnati

2002 -2004 American Heart Association Postdoctoral Fellow A new three-dimensional culture system for in vitro angiogenesis and cardiac tissue engineering

11-1999 2nd place, PhD best paper competition International Mechanical Engineering Congress & Exhibition, Nashville, TN

04-2017 Mid-Career Health Research Award University of Cincinnati

05-2017 Distinguished Research award College of Engineering and Applied Science, University of Cincinnati

05-2015 Translational Research Award International Wound Healing Society

03-2014 Featured on NSF website Laboratory research on novel wound healing therapy is featured on the NSF webpage

01-2014 Research Seed Award University of Cincinnati NSF ADVANCE “UC LEAF” (Leadership, Empowerment, Advancement for Women in Stem Faculty)

05-2013 Anita Roberts award for the best research article published in the journal Wound Repair and Regeneration Wound Healing Society

2016 College of Engineering and Applied Science Master Educator award

11-2011 Nominated for the George S. Barbour Award for Promoting Good Student-Faculty Relations (nominations by students/alumni only)

Student Advising

Swathi Balaji (Doctoral )

Philip Jung (Doctoral )

Jennifer Hurley (Doctoral )

Hongkwan Cho (Doctoral )

Abdul Sheikh (Doctoral )

Varun Krishnamurthy (Doctoral )

John Vennemeyer (Doctoral )

Kyle Rich (Doctoral )

Stephen Perrin (Doctoral )

Kirthi Radhakrishnan (Doctoral )

Matthew Gruber (Doctoral )

Adeola Adeyemo (Doctoral )

Chandra Karunakan (Doctoral )

Jonathan Kopechek (Doctoral )

Kate Hitchcock (Doctoral )

Dahai Gao (Doctoral )

Balakumar Rajendran (Doctoral )

Annette de Kloet

Kirsten Kinneberg

Stephen R. Perrin

Rada Vukmirovich

Andrew Mutchler (Undergrad )

Cameron Ingram (Undergrad )

Laura DeMott (Undergrad )

Shawn Rockey (Undergrad )

Michele Bloomer (Undergrad )

Kristof Nolan (Undergrad )

Brad King (Undergrad )

Kathryn Kadasia (Undergrad )

Andrew Reckers (Undergrad )

Adam Hoenle (Undergrad )

Brent Huxel (Undergrad )

Shaan Sethi (Undergrad )

Matt Gruber (Undergrad )

Maya Harmon (Undergrad )

Karen Marcotte (Undergrad )

Ashley Wheeler (Undergrad )

Theresa Wu (Undergrad )

Brad Herbig (Undergrad )

Danielle L. Bourgeois (Undergrad )

Thea Zimnicki (Undergrad )

Hoi (Justin) Wong (Undergrad )

Sonia Merritt (Undergrad )

Cathy Pham (Undergrad )

Muyiwa Oni (Undergrad )

Suelin Chen (Undergrad )

Toloo Taghian (Doctoral )Advisor Status:Completed 12-2015

Nava Rijal (Doctoral )Status:In Progress

Service

University Research Council (URC) subcommittee on Life Sciences Type:University/College Service 09-2009 -To Present

UC SEEBME web site committee member Type:University/College Service 08-2009 -09-2009

BME Chair Search Committee member Type:University/College Service 03-2009 -08-2009

College of Engineering Awards Committee member Type:University/College Service 09-2007 -To Present

UCBME Graduate Committee member 06-2007 -To Present

Tissue Engineering subcommittee for graduate student recruitment 02-2007

Tissue engineering/biomechanics curriculum committee

(BME Department Head search committee )Member 2016 -To Present

(CEAS workgroup on Improving quality of students )Member 2016 -To Present

(BME strategic development committee )Member 2016 -To Present

(ABET ) Coordinator 2015 -To Present

(CEAS awards committee )2016 -To Present

(CCHMC-CEAS Tissue Engineering & Regenerative Medicine working group )Member 2015 -To Present

(Faculty Hiring Committee: Chemical engineering )Member 2015 -2016

(Faculty Senate Research and Scholarship Committee )2013 -2016

(CEAS Awards Committee )Member 2007 -2011

(BME Graduate Committee )Member 2007 -To Present

(BME Curriculum Committee )2010 -To Present

(CEAS Cluster Hiring Committee – Health Cluster )2014 -2015

(BCEE Department Policy & Procedures Committee )Member 2010 -2013

(BCEE Department Chair search committee )Member 2013 -2014

(UCBME ABET (Research Track) ) Coordinator 2012 -2013

(BME endowed chair search committee )Member 2012 -2013

(ChemE endowed chair search committee )2012 -2013

(CEAS Institute of Materials Science and Engineering Committee )Member 04-2012 -10-2012

(NSF Accend program )2016 -To Present

(NSF REU program )2010 -To Present

(UC WISE - Women in Science and Engineering program )

(Women in Engineering activities )

(Undergraduate and Graduate Student Research Forums )

Positions and Work Experience

2009 -To Present Assistant Professor (adjunct) , in Center for Molecular Fetal Therapy within Division of Pediatric, General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

2005 -To Present Assistant Professor, Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH

2002 -2004 Research Fellow, Cardiovascular Division, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA

2001 -2003 Postdoctoral Associate, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA

2001 - Research Fellow, Department of Vascular Surgery, Massachusetts General Hospital, Boston, MA

1995 -2000 Graduate Research Assistant, Department of Biomedical Engineering, Duke University, Durham, NC

1991 -1994 Research Assistant, Laboratory for Liquid Helium Studies, Kapitza Institute for Physical Problems, Moscow, Russia

2011 -To Present Associate Professor (with tenure), Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH.,

Post Graduate Training and Education

-01-20-2001 Postdoctoral Fellowship, (Development of novel angiogenic scaffold), Massachussetts Institute of Technology, , Cambridge, MA

-06-20-2004 Postdoctoral Fellowship, (Cardiac tissue engineering), Brigham and Women's Hospital, ,Boston, MA

-12-20-2001 Postdoctoral Fellowship, (Effects of shear stress on arteriogenesis), Massachussetts General Hospital, Vascular Surgery, ,Boston, MA

Professional Affiliation

2009 -To Present: Member, Wound Healing Society

2004 -To Present: Member, Biomedical Engineering Society

2002 -To Present: Member, American Heart Association

1997 -To Present: Member, American Society of Mechanical Engineering (Bioengineering Division).

06-2010 -To Present: Chair of the PhD Student Competition Committee American Society of Mechanical Engineers, Bioengineering Division

05-2009 -06-2009: Application Reviewer NIH ARRA Bioengineering Sciences and Technologies Integrated Review Group

06-2009 -03-2010: Chair of the MS Student Competition Committee American Society of Mechanical Engineers, Bioengineering Division

02-2009 -10-2009: Orthopedic Biomaterials Session Organizer and Chair Annual meeting of the Biomedical Engineering Society, October 2009, Pittsburg, PA

06-2008 -05-2009: Chair of the Undergraduate Student Competition Committee American Society of Mechanical Engineers, Bioengineering Division

01-2008 -04-2008: Co-chair of the Organizing Committee (with Dr. Jason Shearn) Midwestern Tissue Engineering Consortium Meeting, April 10-12, Cincinnati, OH

06-2007: Session co-chair Summer Bioengineering Conference, American Society of Mechanical Engineers, Bioengineering Division

2009: Ad-hoc member, NIH ARRA Bioengineering Sciences and Technologies Integrated Review Group

2011: Reviewer, Netherlands Organization for Scientific Research

2013 -2015: Member, VA SPiRE (Small Projects in the Office of Research and Development’s Rehabilitation Research and Development Service) panel

2012 -To Present: Reviewer on more than 15 NIH grant review panels on wound healing and related research

2013 -To Present: Editorial Board Member, Austin Journal of Biomedical Engineering

2014 -To Present: Member, Wound Healing Society Program Committee

2015 -To Present: Member of the Federal Adivisory Committee and RR&D scientific merit review board, Veteran’s Health Administration, US Department of Veterans Affairs

2014 -2015: Chair/Organizer of the Regenerative Medicine Track for the Global Biotechnology Congress 2015

2015 -2016: Fellow, Executive Leadership in Academic Technology and Engineering (ELATE) 2015/2016 program

2016 -2017: Session organizer and chair, International Wound Healing Society Annual Meeting, April 2017

Courses Taught

Patents and Inventions

Effects of high-frequency EMF on angiogenic signaling DA Narmoneva, AB Kogan, 06-05-2009

Chronic and diabetic wound healing with peptide nanoscaffolds and related compositions and methods of use thereof DA Narmoneva, TM Crombleholme, 06-2008

US 20040242469 Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof RT Lee, RD Kamm, DA Narmoneva, S Zhang, ,

UOC-15115P Therapeutic Modulation of Cell Function By An Electric Field DA Narmoneva, AB Kogan, T Taghian,

61/879,268 Method and Device for Treating a Tissue with a High Frequency Electromagnetic Field DA Narmoneva, AB Kogan, AQ Sheikh, T Taghian,

Electromagnetic field for wound healing therapy DA Narmoneva, AB Kogan, AQ Sheikh,

US 20040242469 Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof DA Narmoneva, AB Kogan, AQ Sheikh,

Electromagnetic field for wound healing therapy DA Narmoneva, AB Kogan, AQ Sheikh, 09-18-2013

Preferred Information

Associate Professor, Narmoneva, Daria PhD

Contact Information

Academic - College of Engineering and Applied Science
850 ERC, University of Cincinnati
Ohio, 45221
Phone: 513-556-3997
Fax: 513-556-4162
narmond@uc.edu

Headshot of Liran   Oren

Liran Oren

Asst Professor - Research , COM Oto H&N B

6307B Medical Sciences Building

513-558-0073

Research focus:
Experimental studies of the human upper airway

Technical Expertise:
Experimental fluid dynamics
Aeroacoustics
Image processing 
 
Education

Doctoral Degree, University of Cincinnati (Philosphy in Engineering Mechanics)

Bachelor's Degree, University of Cincinnati (Biomedical Engineering)

Research Support

Grant: #2R01DC009435-06 Investigators:Gutmark, Ephraim; Khosla, Siddarth; Oren, Liran; Ying, Jun 03-19-2015 -02-28-2020 National Institute on Deafness and Other Communication Disor The Relationships Between Vortices, Acoustics, and Vibration in Vocal Fold Asymmetries Role:Collaborator $513,803.00 Awarded Level:Federal

Grant: #K25DC014755-01A1 Investigators:Oren, Liran 03-01-2016 -02-28-2021 National Institute on Deafness and Other Communication Disor Resonance and Aeroacoustic Relationship in Velopharyngeal Insufficiency Role:PI $204,930.00 Awarded Level:Federal

Grant: #NCAI-16-6-APP-UC-Oren / UH54 HL119810 Investigators:Gutmark, Ephraim; Khosla, Siddarth; Oren, Liran 01-01-2017 -12-31-2017 National Heart, Lung and Blood Institute The application of vortex airflow to continuous positive airway pressure (CPAP) therapy Role:PI $119,059.00 Awarded Level:Federal

Grant: #CCL 830-SUB CPAP / U54 HL119810 Investigators:Oren, Liran 04-21-2017 -07-31-2017 National Heart, Lung and Blood Institute The application of vortex airflow to continuous positive airway pressure (CPAP) therapy Role:PI $23,769.00 Active Level:Federal

Publications
Peer Reviewed Publications

Oren, Liran; Khosla, Sid; Murugappan, Shanmugam; King, Richard; Gutmark, Ephraim (2009. )Role of subglottal shape in turbulence reduction. The Annals of otology, rhinology, and laryngology, ,118 (3 ),232-40

Murugappan, Shanmugam; Khosla, Sid; Casper, Keith; Oren, Liran; Gutmark, Ephraim (2009. )Flow fields and acoustics in a unilateral scarred vocal fold model. The Annals of otology, rhinology, and laryngology, ,118 (1 ),44-50

Oren, Liran; Dembinski, Doug; Gutmark, Ephraim; Khosla, Sid (2014. )Characterization of the vocal fold vertical stiffness in a canine model.Journal of voice : official journal of the Voice Foundation, ,28 (3 ),297-304

Oren, Liran; Khosla, Sid; Gutmark, Ephraim (2014. )Intraglottal pressure distribution computed from empirical velocity data in canine larynx.Journal of biomechanics, ,47 (6 ),1287-93

Khosla, Sid; Oren, Liran; Ying, Jun; Gutmark, Ephraim (2014. )Direct simultaneous measurement of intraglottal geometry and velocity fields in excised larynges.The Laryngoscope, ,124 Suppl 2 ,S1-13

Oren, Liran; Khosla, Sid; Gutmark, Ephraim (2014. )Intraglottal geometry and velocity measurements in canine larynges.The Journal of the Acoustical Society of America, ,135 (1 ),380-8

Oren, Liran; Gutmark, Ephraim; Khosla, Sid (2015. )Intraglottal velocity and pressure measurements in a hemilarynx model.The Journal of the Acoustical Society of America, ,137 (2 ),935-43

Oren, Liran; Khosla, Sid; Dembinski, Doug; Ying, Jun; Gutmark, Ephraim (2015. )Direct measurement of planar flow rate in an excised canine larynx model.The Laryngoscope, ,125 (2 ),383-8

Preferred Information

Oren, Liran

Contact Information

Academic - University of Cincinnati
Phone: 513-558-0073

Headshot of Albert Owens

Albert Owens

Assistant Professor Division of Cardiovascular Health and Disease , COM IM Cardiology Division

3925 Cardiovascular Rsrch Cntr

513-558-3428

Education

Doctoral Degree, University of Kentucky 2009

Research Support

Grant: #R00 HL116786 Investigators:Owens, Albert 03-15-2015 -02-28-2018 National Heart, Lung and Blood Institute Tissue Factor & Clot Formation in Abdominal Aortic Aneurysm Role:PI $348,937.00 Awarded Level:Federal

Grant: #R01HL141404 Investigators:Owens, Albert; Tranter, Michael 05-01-2018 -03-31-2023 National Heart, Lung and Blood Institute The role of protease-activated receptor 2 in atherosclerosis Role:PI $399,792.00 Awarded Level:Federal

Grant: #F31 HL143987 Investigators:Anderson, Heather; Owens, Albert; Russell, Hannah 09-01-2018 -08-31-2019 National Heart, Lung and Blood Institute Fibrin(ogen) in Abdominal Aortic Aneurysm Pathogenesis Role:Collaborator $37,205.00 Active Level:Federal

Publications
Peer Reviewed Publications

Sweet DT, Chen Z, Givens CS, Owens AP, Rojas M, Tzima E (2013. )Endothelial Shc Regulates Arteriogenesis Through Dual Control of Arterial Specification and Inflammation via the Notch and NF-κB Pathways. Circulation Research, ,113 (1 ),32

Antoniak SA, Owens P, Baunacke M, Williams JC, Lee RD, Weithaeuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N (2013. )PAR-1 Contributes to the Innate Immune Response During Viral Infection .The Journal of Clinical Investigation, ,123 (3 ),1310

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP, Ware J, Kahn ML, Bergmeier W (2013. )Platelet ITAM Signaling is Critical for Vascular Integrity in Inflammation. The Journal of Clinical Investigation, ,123 (2 ),908

Aruna Poduri, A. Phillip Owens III, Deborah A. Howatt, Jessica J. Moorleghen, Anju Balakrishnan, Lisa A. Cassis, and Alan Daugherty (2012. )Regional Variation in Aortic AT1b Receptor mRNA Abundance is Associated with Contractility but Unrelated to Atherosclerosis and Aortic Aneurysms .PLoS One, ,7 (10 ),e48462

Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton J, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N (2012. )Monocyte Tissue Factor-dependent Activation of coagulation in Hypercholesterolemic Mice and Monkeys is Inhibited by Simvastatin. .The Journal of Clinical Investigation, ,122 (2 ),558

Owens AP, Howatt DA, Moore KJ, Tobias PS, Curtiss LA, Cassis LA, Daugherty A (2011. )MyD88 Deficiency Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-like Receptors 2 and 4 .Arteriosclerosis, Thrombosis, and Vascular Biology, ,12 ,2813

Boulaftali, Yacine; Owens, A Phillip; Beale, Ashley; Piatt, Raymond; Casari, Caterina; Lee, Robert H; Conley, Pamela B; Paul, David S; Mackman, Nigel; Bergmeier, Wolfgang (2016. )CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.Arteriosclerosis, thrombosis, and vascular biology, ,36 (5 ),792-9

Owens, A Phillip; Edwards, Todd L; Antoniak, Silvio; Geddings, Julia E; Jahangir, Eiman; Wei, Wei-Qi; Denny, Joshua C; Boulaftali, Yacine; Bergmeier, Wolfgang; Daugherty, Alan; Sampson, Uchechukwu K A; Mackman, Nigel (2015. )Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.Arteriosclerosis, thrombosis, and vascular biology, ,35 (9 ),2032-41

Rautou, Pierre-Emmanuel; Tatsumi, Kohei; Antoniak, Silvio; Owens, A Phillip; Sparkenbaugh, Erica; Holle, Lori A; Wolberg, Alisa S; Kopec, Anna K; Pawlinski, Rafal; Luyendyk, James P; Mackman, Nigel (2016. )Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury.Journal of hepatology, ,64 (1 ),53-9

Østerud, B; Unruh, D; Olsen, J O; Kirchhofer, D; Owens, A P; Bogdanov, V Y (2015. )Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes.Journal of thrombosis and haemostasis : JTH, ,13 (9 ),1676-82

Kopec, Anna K; Abrahams, Sara R; Thornton, Sherry; Palumbo, Joseph S; Mullins, Eric S; Divanovic, Senad; Weiler, Hartmut; Owens, A Phillip; Mackman, Nigel; Goss, Ashley; van Ryn, Joanne; Luyendyk, James P; Flick, Matthew J (2017. )Thrombin promotes diet-induced obesity through fibrin-driven inflammation.The Journal of clinical investigation, ,127 (8 ),3152-3166

Research and Practice Interests

The primary focus of my research is to examine the effects of coagulation proteins, proteases, and receptors in the pathogenesis cardiovascular disease (CVD), specifically atherosclerosis and abdominal aortic aneurysms (AAAs).  We utilize genetically modified mice and mouse models of disease to generate data and attempt to verify these results in the human condition, when possible, with retrospective clinical data or human specimens.  While several drug therapies exist for atherosclerosis, there are currently no pharmaceutical therapies for patients with AAA.  Further, even with modern pharmaceutical regiments for patients with coronary artery disease, it is still the leading cause of mortality. Therefore, the long-term goals of my work are to increase the understanding of thrombosis in atherosclerotic and aneurysmal disease and translate these findings into effective therapeutics to improve survival and quality of life for CVD patients.
 
Atherosclerotic disease is the leading cause of worldwide mortality with an estimated 7.4 million attributable deaths occurring in 2012. Abdominal aortic aneurysm (AAA) affects 5-10% of the male and female population over the age of 65 and is the 10th leading cause of death in the United States.  Histopathology of these two arterial diseases is similar with infiltrates of lipids, platelets, vascular smooth muscle cells (VSMC), macrophages (foam cells), T and B lymphocytes, and extracellular matrix resulting in severe inflammation. In atherosclerosis, cell and matrix deposition results in narrowed blood vessels and restricted blood flow leading to thrombus, ischemic stroke, or coronary occlusion; in AAA, such deposition results in a permanent localized dilatation in the arterial wall, formation of intramural clots, elastin and collagen destruction, and life-threatening aortic wall rupture. The fundamental connection between these two arterial diseases is the acute immune reaction to endogenous ligands, i.e. ‘sterile inflammation,’ and activation of the coagulation cascade.
 
 

Preferred Information

Assistant Professor Division of Cardiovascular Health and Disease, Owens, Phillip PhD

Contact Information

Academic - Medical Sciences Building
231 Albert Sabin Way, MLC 0542
Ohio, 45267
Phone: 513-558-3428
phillip.owens@uc.edu

Headshot of Sarah K Pixley

Sarah K Pixley

Associate Professor of Molecular & Cellular Physiology , COM Physiology Pixley Lab

4206A Medical Sciences Building

513-558-6086

 
Research in the Pixley lab has moved from a past emphasis on the neurogenesis and neuropharmacology of the olfactory system into more applied neural tissue repair work. Our current focus is on using novel biomaterials to promote neural tissue repair and regeneration. One of the most promising biomaterials is magnesium, primarily in metal form. Magnesium metal has properties that have increasingly attracted attention in recent years for use as a bioresorbable biomedical implant material. The most advanced uses are currently as bone fixation devices and as a cardiovascular stent material. Magnesium metal is strong initially, then very safely resorbs into the body. We are identifying novel ways to use magnesium metal to improve recovery of nervous tissues from injury damage, focusing first on repairing injury cuts in peripheral nerves in rats. We are also exploring the use of ionic magnesium for nervous tissue repair. Magnesium in ionic form is known to be neuroprotective and aids recovery of brain tissues after traumatic injury or stroke. Magnesium ions reduce secondary neuronal damage that occurs after the initial injury and reduce vasospasm that occurs in the brain after damage and is also damagine. Our collaborative group includes surgeons, neurobiologists, neuropathologists, and engineers from many categories. We are currently funded by an NSF grant that supports an Engineering Research Center dedicated to Revolutionizing Metallic Biomaterials (http://erc.ncat.edu/).  As a second focus, the lab is exploring the use of carbon nanotube (CNT) materials for nervous tissue repair. Expert engineering groups at UC produce novel forms of CNT materials, which are linear biomaterials with promise for promoting neuronal outgrowth and repair. Our initial work shows that neuronal stem cells migrate readily along CNT thread and complete differentiation. We are also using CNT materials to guide nervous tissue repair. 
Education

A.B., Smith College Northampton, Massachusets, 1974 (Zoology)

M.S., University of California at Los Angeles (UCLA) Los Angeles, CA, 1975 (Physiology)

Ph.D., University of California at Los Angeles (UCLA) Los Angeles, CA, 1983 (Anatomy)

Research Support

Grant: #NSF EEC-0812348 Investigators:PI: Jag Sankar 09-01-2008 -08-31-2019 NSF Engineering Research Center: "Revolutionizing Metallic Biomaterials", Subproject: Biosensors and Neural Applications Role:PI of Subproject Active Type:Grant Level:International

Grant: #260116C / EEC-0812348 Investigators:Pixley, Sarah; Schulz, Mark; Shanov, Vesselin 01-01-2010 -12-31-2012 National Science Foundation ERC: Revolutionizing Metallic Biomaterials, Supplemental Role:Collaborator $64,999.00 Active Type:Grant Level:International

Grant: #SRS 008475 Investigators:Pixley, Sarah 07-01-2013 -06-30-2014 American Association for Hand Surgery Peripheral Nerve Repair with Bioresorbable Metal Role:PI $10,000.00 Completed

Grant: #VA IPA - Hopkins Investigators:Hopkins, Tracy; Pixley, Sarah; Wagner, Kenneth 03-01-2013 -08-31-2013 Department of Veterans Affairs Intergovernmental Personnel Act Agreement - Hopkins Role:Collaborator $15,108.00 Completed

Grant: #000035 Investigators:Pixley, Sarah 11-11-2005 -11-30-2007 Janssen Pharmaceutica Research Foundation Neuroprotective Effects of Paliperidone: A Controlled Study of its Neurogenic Effects in the Olfactory Neuroepithlium Role:PI $249,563.00 Closed Level:Industry

Grant: #CORE Research Grant Investigators:Hershcovitch, Meir; Hom, David; Pixley, Sarah 07-01-2013 -06-30-2014 American Academy of Otolaryngology-Head and Neck Surgery Fou Nervous Tissue Repair Role:Collaborator $5,000.00 Completed Type:Fellowship Level:National

Grant: #5-P01-DC-00347-13-A0-S0-E0 Investigators:Pixley, Sarah 09-01-1994 -08-31-1999 National Institute on Deafness and Other Communication Disor Differentiation of Olfactory Receptor Neurons in Culture Role:PI $861,568.00 Closed Level:Federal

Investigators:Pixley, S.K. 09-01-2015 -08-31-2016 NSF LEAF grant to Univ. of Cincinnati The development of magnesium metal-containing fabric for wound repair Role:PI 3,000 Active Type:Grant Level:University

Publications
Peer Reviewed Publications

Nasrallah, Henry A; Hopkins, Tracy; Pixley, Sarah K (2010. )Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats.Brain research, ,1354 ,23-9

Loftspring, M C; Smanik, J; Gardner, C; Pixley, S K (2008. )Selective gray matter staining of human brain slices: optimized use of cadaver materials.Biotechnic & histochemistry : official publication of the Biological Stain Commission, ,83 (3 ),173-7

Ferrari, Carina C; Johnson, Brett A; Leon, Michael; Pixley, Sarah K (2003. )Spatiotemporal distribution of the insulin-like growth factor receptor in the rat olfactory bulb .Neurochemical research, ,28 (1 ),29-43

McEntire, J K; Pixley, S K (2000. )Olfactory receptor neurons in partially purified epithelial cell cultures: comparison of techniques for partial purification and identification of insulin as an important survival factor. Chemical senses, ,25 (1 ),93-101

Koster, N L; Norman, A B; Richtand, N M; Nickell, W T; Puche, A C; Pixley, S K; Shipley, M T (1999. )Olfactory receptor neurons express D2 dopamine receptors. The Journal of comparative neurology, ,411 (4 ),666-73

Pixley, S K; Dangoria, N S; Odoms, K K; Hastings, L (1998. )Effects of insulin-like growth factor 1 on olfactory neurogenesis in vivo and in vitro. Annals of the New York Academy of Sciences, ,855 ,244-7

Szucsik, J C; Witte, D P; Li, H; Pixley, S K; Small, K M; Potter, S S (1997. )Altered forebrain and hindbrain development in mice mutant for the Gsh-2 homeobox gene.Developmental biology, ,191 (2 ),230-42

Pixley, S K; Farbman, A I; Menco, B P (1997. )Monoclonal antibody marker for olfactory sustentacular cell microvilli. The Anatomical record, ,248 (3 ),307-21

Grill, R J; Pixley, S K (1997. )In vitro generation of adult rat olfactory sensory neurons and regulation of maturation by coculture with CNS tissues. The Journal of neuroscience : the official journal of the Society for Neuroscience, ,17 (9 ),3120-7

Pixley, S K (1996. )Characterization of olfactory receptor neurons and other cell types in dissociated rat olfactory cell cultures. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, ,14 (7-8 ),823-39

Lee, V M; Pixley, S K (1994. )Age and differentiation-related differences in neuron-specific tubulin immunostaining of olfactory sensory neurons. Brain research. Developmental brain research, ,83 (2 ),209-15

Gong, Q; Bailey, M S; Pixley, S K; Ennis, M; Liu, W; Shipley, M T (1994. )Localization and regulation of low affinity nerve growth factor receptor expression in the rat olfactory system during development and regeneration.The Journal of comparative neurology, ,344 (3 ),336-48

Pixley, S K; Bage, M; Miller, D; Miller, M L; Shi, M; Hastings, L (1994. )Olfactory neurons in vitro show phenotypic orientation in epithelial spheres. Neuroreport, ,5 (5 ),543-8

Lu, S Y; Pixley, S K; Emerich, D F; Lehman, M N; Norman, A B. (1993. )Effect of fetal striatal and astrocyte transplants into unilateral excitotoxin-lesioned striatum.Journal of neural transplantation & plasticity, ,4 (4 ),279-87

Grill, R J; Pixley, S K (1993. )2-Mercaptoethanol is a survival factor for olfactory, cortical and hippocampal neurons in short-term dissociated cell culture. Brain research, ,613 (1 ),168-72

Pixley, S K (1992. )CNS glial cells support in vitro survival, division, and differentiation of dissociated olfactory neuronal progenitor cells. Neuron, ,8 (6 ),1191-204

Crowe, M J; Pixley, S K (1992. )Species differences in amphibian olfactory neuron reactivity to a monoclonal antibody. Brain research bulletin, ,28 (5 ),785-8

Pixley, S K (1992. )Purified cultures of keratin-positive olfactory epithelial cells: identification of a subset as neuronal supporting (sustentacular) cells.Journal of neuroscience research, ,31 (4 ),693-707

Pixley, S K (1992. )The olfactory nerve contains two populations of glia, identified both in vivo and in vitro.Glia, ,5 (4 ),269-84

Crowe, M J; Pixley, S K (1991. )Monoclonal antibody to carnosine synthetase identifies a subpopulation of frog olfactory receptor neurons. Brain research, ,538 (1 ),147-51

Pixley, S K; Pun, R Y (1990. )Cultured rat olfactory neurons are excitable and respond to odors. Brain research. Developmental brain research, ,53 (1 ),125-30

Pixley, S K; Nieto-Sampedro, M; Cotman, C W (1987. )Preferential adhesion of brain astrocytes to laminin and central neurites to astrocytes.Journal of neuroscience research, ,18 (3 ),402-6

Gibbs, R B; Pixley, S K; Cotman, C W (1986. )Transplantation of septal neurons maintained in long-term culture. Brain research, ,382 (2 ),409-15

Pixley, S K; Cotman, C W (1986. )Laminin supports short-term survival of rat septal neurons in low-density, serum-free cultures.Journal of neuroscience research, ,15 (1 ),1-17

Pixley, S K; de Vellis, J (1984. )Transition between immature radial glia and mature astrocytes studied with a monoclonal antibody to vimentin. Brain research, ,317 (2 ),201-9

Pixley, S K; Kobayashi, Y; de Vellis, J (1984. )A monoclonal antibody against vimentin: characterization. Brain research, ,317 (2 ),185-99

Pixley, S K; Kobayashi, Y; de Vellis, J (1984. )Monoclonal antibody to intermediate filament proteins in astrocytes.Journal of neuroscience research, ,12 (4 ),525-41

Hopkins T, Vennemeyer J, Jayasinghe C, Shanov V + Pixley S (2010. )Carbon nanotube ribbon and thread support attachment and differentiation of neural stem cells .NanoLife, ,1 (1-2 ),89-97

Yun, Y, Pixley, S, Cui, XT, Dong, Z, Collins, B, Shanov, V, Ko, S, Pai, D, Yarmolenko, S, Schulz, MJ, Sankar, J. (2012. )Carbon nanomaterials: from therapeutics to regenerative medicine .Journal of Nanomedicine and Biotherapeutics Discovery, ,2 ,1

Schulz MJ, Doepke A, Guo X, Kuhlmann J, Halsall B, Heineman W, Dong Z, Tan Z, Xue D, Lee N, Yun Y, Liu Y, Hurd D, Shanov V, Rai D, Witte F, Kumar D, Yarmolenko S, Pixley SK, Hopkins T, Jayasinghe C, Sundaramurthy S (2010. )Responsive biosensors for biodegradable magnesium implants .ASME Intl Mech Eng Congress & Expo Proc, ,14 ,109-116

Tong, J., Mannea, E., Aimé, P., Pfluger, P.T., Yi, C.-X., Castaneda, T.R., Davis, H.W., Ren, X., Pixley, S., Benoit, S., Julliard, K., Woods, S.C., Horvath, T.L., Sleeman, M.M., D'Alessio, D., Obici, S., Frank, R., Tschöp, M.H.. (2011. )Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans.Journal of Neuroscience, ,31 (15 ),5841–5846

Hopkins, Tracy M; Heilman, Alexander M; Liggett, James A; LaSance, Kathleen; Little, Kevin J; Hom, David B; Minteer, Danielle M; Marra, Kacey G; Pixley, Sarah K (2015. )Combining micro-computed tomography with histology to analyze biomedical implants for peripheral nerve repair.Journal of neuroscience methods, ,255 ,122-30

Vennemeyer, J J; Hopkins, T; Hershcovitch, M; Little, K D; Hagen, M C; Minteer, D; Hom, D B; Marra, K; Pixley, S K (2015. )Initial observations on using magnesium metal in peripheral nerve repair.Journal of biomaterials applications, ,29 (8 ),1145-54

Vennemeyer, John J; Hopkins, Tracy; Kuhlmann, Julia; Heineman, William R; Pixley, Sarah K (2014. )Effects of elevated magnesium and substrate on neuronal numbers and neurite outgrowth of neural stem/progenitor cells in vitro.Neuroscience Research, ,84 ,72-78

Griebel, Adam J; Schaffer, Jeremy E; Hopkins, Tracy M; Alghalayini, Alaa; Mkorombindo, Tinomudaishe; Ojo, Kolade O; Xu, Zhigang; Little, Kevin J; Pixley, Sarah K (2018. )An in vitro and in vivo characterization of fine WE43B magnesium wire with varied thermomechanical processing conditions.Journal of Biomedical Materials Research. Part B, Applied Biomaterials, ,106 (5 ),1987-1997

An in vitro and in vivo characterization of fine WE43B magnesium wire

Hopkins, Tracy M; Little, Kevin J; Vennemeyer, John J; Triozzi, Jefferson L; Turgeon, Michael K; Heilman, Alexander M; Minteer, D; Marra, K; Hom, David B; Pixley, Sarah K (2017. )Short and long gap peripheral nerve repair with magnesium metal filaments.Journal of biomedical materials research. Part A, ,105 (11 ),3148-3158

Pixley, Sarah K; Hopkins, Tracy M; Little, Kevin J; Hom, David B (2016. )Evaluation of peripheral nerve regeneration through biomaterial conduits via micro-CT imaging.Laryngoscope investigative otolaryngology, ,1 (6 ),185-190

Post Graduate Training and Education

1983-1985 Postdoctoral Student, Advisor: Dr. Carl Cotman, Univeristy of California, Irvine, ,Irvine, CA

1985-1987 Postdoctoral Student, Advisor: Dr. Shlomo Melmed, Cedars-Sinai Medical Center, ,Los Angeles, CA

Keywords

Nervous system repair, neural regeneration, magnesium, peripheral nerve, peripheral nerve injury, sciatic nerve, Tissue Engineering, biomedical implant, carbon nanotubes

Research and Practice Interests

Research in the Pixley lab has moved from a past emphasis on the neurogenesis and neuropharmacology of the olfactory system into more applied neural tissue repair work. Our current focus is on using novel biomaterials to promote neural tissue repair and regeneration. One of the most promising biomaterials is magnesium, primarily in metal form. Magnesium metal has properties that have increasingly attracted attention in recent years for use as a bioresorbable biomedical implant material. The most advanced uses are currently as bone fixation devices and as a cardiovascular stent material. Magnesium metal is strong initially, then very safely resorbs into the body. We are identifying novel ways to use magnesium metal to improve recovery of nervous tissues from injury damage, focusing first on repairing injury cuts in peripheral nerves in rats. We are also exploring the use of ionic magnesium for nervous tissue repair. Magnesium in ionic form is known to aid recovery of brain tissues after traumatic injury or stroke. Raising magnesium ions reduces secondary neuronal damage that occurs after the initial injury and reduces vasospasm in the brain after damage. Our collaborative group includes surgeons, neurobiologists, neuropathologists, and engineers. We are currently funded by an NSF grant that supports an Engineering Research Center dedicated to Revolutionizing Metallic Biomaterials (http://erc.ncat.edu/).  As a second focus, the lab is exploring the use of carbon nanotube (CNT) materials for nervous tissue repair. Expert engineering groups at UC produce novel forms of CNT materials, which are linear biomaterials with promise for promoting neuronal outgrowth and repair. Our initial work shows that neuronal stem cells migrate readily along CNT thread and complete differentiation. We are also using CNT materials to guide nervous tissue repair. 

Preferred Information

Associate Professor of Molecular & Cellular Physiology, Pixley, Sarah PhD

Contact Information

Academic - Office: MSB 4206A
Dept. of Pharmacology & Systems Physiology
Ohio, 45267-0576
Phone: (513)558-6086
Fax: (513)558-5738
sarah.pixley@uc.edu

Headshot of Xiaoyang Qi

Xiaoyang Qi

Professor of Medicine, Co-Division Chief for Basic Science Research , COM IM Hematology/Oncology Division

1314 Vontz Center

513-558-4025

Education

Bachelor's Degree, Nanjing University 1982 (Biochemistry)

Doctoral Degree, Oklahoma Sate University 1992 (Biochemistry and Molecular Biology)

Research Fellowship , Cincinnati Children's Hospital Medical Center 1996 (Human Genetics)

Research Support

Investigators:Xiaoyang Qi, Vladimir Bogdanov 07-01-2012 -06-30-2014 NIH Tissue factor splicing and pancreatic tumor progression: pilot studies Role:Co-PI Active Type:Grant

Investigators:Xiaoyang Qi 2012 -2013 UC Neurosurgery Research Fund In vivo MR microscopy of novel proteolipid nanovesicle incorporatin gadolium chelate Role:PI Active Type:Grant

Investigators:Xiaoyang Qi 12-01-2011 -11-30-2012 UC Brain Tumor Molecular Therapeutics Program SapC-DOPS nanovesicles: brain metastases targeting agents Role:PI Active Type:Grant

Investigators:Xiaoyang Qi 09-27-2011 -07-31-2016 NIH Acidic phospholipid-selective treatment for neuroblastoma Role:PI Active Type:Grant

2010 -2012 NIH R44 SapC-DOPS nanovesicles for treating glioblastoma multiforme Role:Co-PI

2010 -2011 NIH Clinical and Translational Sciences Award (CTSA) & The Center for Clinical and Translational Science and Training (CCTST) SapC-DOPS agents: Imaging and therapeutics in arthritis Role:Co-PI

2010 -2012 SISENE, France Lab Service Contract Role:PI

2009 -2011 Bexion Pharmaceuticals Lab Service Contract Role:PI

2008 -2009 NIH R43 A novel biotherapeutic treatment for pancreatic cancer Role:Co-PI

Grant: #R44 CA136017 Investigators:Qi, Xiaoyang 05-01-2011 -08-31-2012 National Cancer Institute Tunable Bandstop Filters for Suppression of Co-Site Interference and Jamming Sources Role:PI $241,555.00 Closed Level:Federal

Grant: #SRS 007740 Investigators:Qi, Xiaoyang 08-01-2011 -01-31-2013 Sisene SAS NOV-CT Effects on Human Gliomas Role:PI $60,488.00 Closed Level:Foreign Industry

Grant: #R01 CA158372 Investigators:Franco, Robert; Qi, Xiaoyang; Welge, Jeffrey 09-27-2011 -07-31-2016 National Cancer Institute Acidic Phospholipid- Selective Treatment for Neurobalstoma Role:PI $970,735.00 Active Level:Federal

Grant: #R21CA160293 Investigators:Bogdanov, Vladimir; Qi, Xiaoyang; Shukla, Rakesh 07-11-2012 -06-30-2014 National Cancer Institute Tissue Factor Splicing and Pancreatic Tumor Progression: Pilot Studies Role:Collaborator $363,330.00 Active Level:Federal

Grant: #Sub to 5R44CA136017 Investigators:Qi, Xiaoyang 09-01-2014 -08-31-2016 National Cancer Institute SapC-DOPS Nanovesicles: Biotherapeutic Agent for Pediatric Cancer Role:PI $103,028.00 Awarded Level:Federal

Grant: #R21NS095047 Investigators:Blanco, Victor; Qi, Xiaoyang 08-31-2015 -08-30-2017 National Institute of Neurological Disorders and Stroke Intravenous Enzyme Replacement Therapy for CNS Disorders Role:PI $250,450.00 Awarded Level:Federal

Grant: #MTTI2017BBT / HHSN26120170038C Investigators:Qi, Xiaoyang 09-18-2017 -06-17-2018 National Cancer Institute Biotherapy of brain tumors by radioiodinated SapC-DOPS nanovesicles Role:PI $91,989.79 Active Level:Federal

Grant: #2017 MTTI Agreement Investigators:Qi, Xiaoyang 09-18-2017 -06-30-2018 Molecular Targeting Technologies, Inc. Biotherapy of brain tumors by radioiodinated SapC-DOPS nanovesicles Role:PI $74,521.21 Awarded Level:Industry

Publications
Peer Reviewed Publications

X. Qi, M.J. Flick, M. Frederick, Z. Chu, R. Mason, M. Delay, and S. Thornton, (2012. )Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity .PLoS One, ,7 ,e33966

S. Abu-Baker, Z. Chu, A.M. Stevens, J. Li, and X. Qi (2012. )Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles .J. Cancer Ther, ,3 ,321-326

A. Liu and X. Qi (2012. )Molecular dynamics simulations of DOPC lipid bilayers: effect of Lennard-Jones parameters of the hydrocarbon chains .Comput. Mol. Biosci, ,2 ,78-82

Lu, Kaihua; Zhao, Guangfeng; Lu, Hongna; Zhao, Shuli; Song, Yuxian; Qi, Xiaoyang; Hou, Yayi (2011. )Toll-like receptor 4 can recognize SapC-DOPS to stimulate macrophages to express several cytokines.Inflammation research : official journal of the European Histamine Research Society ... [et al.], ,60 (2 ),153-61

Kaimal, Vinod; Chu, Zhengtao; Mahller, Yonatan Y; Papahadjopoulos-Sternberg, Brigitte; Cripe, Timothy P; Holland, Scott K; Qi, Xiaoyang (2010. )Saposin C Coupled Lipid Nanovesicles Enable Cancer-Selective Optical and Magnetic Resonance Imaging.Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, ,

Qi, Xiaoyang; Chu, Zhengtao; Mahller, Yonatan Y; Stringer, Keith F; Witte, David P; Cripe, Timothy P (2009. )Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein.Clinical cancer research : an official journal of the American Association for Cancer Research, ,15 (18 ),5840-51

Nieh, Mu-Ping; Katsaras, John; Qi, Xiaoyang (2008. )Controlled release mechanisms of spontaneously forming unilamellar vesicles.Biochimica et biophysica acta, ,1778 (6 ),1467-71

Abu-Baker, Shadi; Qi, Xiaoyang; Lorigan, Gary A (2007. )Investigating the interaction of saposin C with POPS and POPC phospholipids: a solid-state NMR spectroscopic study.Biophysical journal, ,93 (10 ),3480-90

Yuan, Weiming; Qi, Xiaoyang; Tsang, Pansy; Kang, Suk-Jo; Illarionov, Petr A; Illaniorov, Petr A; Besra, Gurdyal S; Gumperz, Jenny; Cresswell, Peter (2007. )Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules.Proceedings of the National Academy of Sciences of the United States of America, ,104 (13 ),5551-6

Nieh, Mu-Ping; Pencer, Jeremy; Katsaras, John; Qi, Xiaoyang (2006. )Spontaneously forming ellipsoidal phospholipid unilamellar vesicles and their interactions with helical domains of saposin C.Langmuir : the ACS journal of surfaces and colloids, ,22 (26 ),11028-33

Liu, Anping; Wenzel, Nathan; Qi, Xiaoyang (2005. )Role of lysine residues in membrane anchoring of saposin C.Archives of biochemistry and biophysics, ,443 (1-2 ),101-12

Abu-Baker, Shadi; Qi, Xiaoyang; Newstadt, Justin; Lorigan, Gary A (2005. )Structural changes in a binary mixed phospholipid bilayer of DOPG and DOPS upon saposin C interaction at acidic pH utilizing 31P and 2H solid-state NMR spectroscopy.Biochimica et biophysica acta, ,1717 (1 ),58-66

Chu, Zhengtao; Sun, Ying; Kuan, Chia Yi; Grabowski, Gregory A; Qi, Xiaoyang (2005. )Saposin C: neuronal effect and CNS delivery by liposomes.Annals of the New York Academy of Sciences, ,1053 ,237-46

Chu, Zhengtao; Witte, David P; Qi, Xiaoyang (2005. )Saposin C-LBPA interaction in late-endosomes/lysosomes.Experimental cell research, ,303 (2 ),300-7

Ryan, Marnie A; Qi, Xiaoyang; Serrano, Alicia G; Ikegami, Machiko; Perez-Gil, Jesus; Johansson, Jan; Weaver, Timothy E (2005. )Mapping and analysis of the lytic and fusogenic domains of surfactant protein B.Biochemistry, ,44 (3 ),861-72

You, Hong Xing; Qi, Xiaoyang; Yu, Lei (2004. )Direct AFM observation of saposin C-induced membrane domains in lipid bilayers: from simple to complex lipid mixtures.Chemistry and physics of lipids, ,132 (1 ),15-22

Qi, Xiaoyang; Chu, Zhengtao (2004. )Fusogenic domain and lysines in saposin C.Archives of biochemistry and biophysics, ,424 (2 ),210-8

Zhou, Dapeng; Cantu, Carlos; Sagiv, Yuval; Schrantz, Nicolas; Kulkarni, Ashok B; Qi, Xiaoyang; Mahuran, Don J; Morales, Carlos R; Grabowski, Gregory A; Benlagha, Kamel; Savage, Paul; Bendelac, Albert; Teyton, Luc (2004. )Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins.Science (New York, N.Y.), ,303 (5657 ),523-7

Sun, Ying; Qi, Xiaoyang; Grabowski, Gregory A (2003. )Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation.The Journal of biological chemistry, ,278 (34 ),31918-23

Wang, Ying; Grabowski, Gregory A; Qi, Xiaoyang (2003. )Phospholipid vesicle fusion induced by saposin C. Archives of biochemistry and biophysics, ,415 (1 ),43-53

You, Hong Xing; Qi, Xiaoyang; Grabowski, Gregory A; Yu, Lei (2003. )Phospholipid membrane interactions of saposin C: in situ atomic force microscopic study.Biophysical journal, ,84 (3 ),2043-57

Sun, Ying; Qi, Xiaoyang; Witte, David P; Ponce, Elvira; Kondoh, Keiji; Quinn, Brian; Grabowski, Gregory A (2002. )Prosaposin: threshold rescue and analysis of the "neuritogenic" region in transgenic mice. Molecular genetics and metabolism, ,76 (4 ),271-86

Qi, Xiaoyang; Kondoh, Keiji; Yin, Hulian; Wang, Mei; Ponce, Elvira; Sun, Ying; Grabowski, Gregory A (2002. )Ex vivo localization of the mouse saposin C activation region for acid beta-glucosidase. Molecular genetics and metabolism, ,76 (3 ),189-200

Cheng, Yizong; Liu, Anping; Guo, Yuping; Qi, Xiaoyang Computational models for the helix tilt angle.Journal of chemical information and computer sciences, ,44 (6 ),1952-60

Koncar, Robert F; Chu, Zhengtao; Romick-Rosendale, Lindsey E; Wells, Susanne I; Chan, Timothy A; Qi, Xiaoyang; Bahassi, El Mustapha (2017. )PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas.Oncotarget, ,8 (9 ),15827-15837

Blanco, Víctor M; Chu, Zhengtao; LaSance, Kathleen; Gray, Brian D; Pak, Koon Yan; Rider, Therese; Greis, Kenneth D; Qi, Xiaoyang (2016. )Optical and nuclear imaging of glioblastoma with phosphatidylserine-targeted nanovesicles.Oncotarget, ,7 (22 ),32866-75

Davis, Harold W; Hussain, Nida; Qi, Xiaoyang (2016. )Detection of cancer cells using SapC-DOPS nanovesicles.Molecular cancer, ,15 (1 ),33

Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y (2016. )Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma.Oncotarget, ,7 (18 ),25264-75

Barber, Latorya A; Palascak, Mary B; Qi, Xiaoyang; Joiner, Clinton H; Franco, Robert S (2015. )Activation of protein kinase C by phorbol ester increases red blood cell scramblase activity and external phosphatidylserine.European journal of haematology, ,95 (5 ),405-10

Vallabhapurapu, Subrahmanya D; Blanco, Víctor M; Sulaiman, Mahaboob K; Vallabhapurapu, Swarajya Lakshmi; Chu, Zhengtao; Franco, Robert S; Qi, Xiaoyang (2015. )Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium.Oncotarget, ,6 (33 ),34375-88

Zhou, Xiaolai; Sun, Lirong; Bastos de Oliveira, Francisco; Qi, Xiaoyang; Brown, William J; Smolka, Marcus B; Sun, Ying; Hu, Fenghua (2015. )Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.The Journal of cell biology, ,210 (6 ),991-1002

Blanco, Victor M; Latif, Tahir; Chu, Zhengtao; Qi, Xiaoyang (2015. )Imaging and Therapy of Pancreatic Cancer with Phosphatidylserine-Targeted Nanovesicles.Translational oncology, ,8 (3 ),196-203

Sulaiman, Mahaboob K; Chu, Zhengtao; Blanco, Victor M; Vallabhapurapu, Subrahmanya D; Franco, Robert S; Qi, Xiaoyang (2015. )SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas.Molecular cancer, ,14 ,78

Winter, Patrick M; Pearce, John; Chu, Zhengtao; McPherson, Christopher M; Takigiku, Ray; Lee, Jing-Huei; Qi, Xiaoyang (2015. )Imaging of brain tumors with paramagnetic vesicles targeted to phosphatidylserine.Journal of magnetic resonance imaging : JMRI, ,41 (4 ),1079-87

Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B (2015. )Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.Molecular cancer therapeutics, ,14 (4 ),857-64

Blanco, Víctor M; Curry, Richard; Qi, Xiaoyang (2015. )SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastoma.Oncoscience, ,2 (2 ),102-10

Zhao, Shuli; Chu, Zhengtao; Blanco, Victor M; Nie, Yunzhong; Hou, Yayi; Qi, Xiaoyang (2015. )SapC-DOPS nanovesicles as targeted therapy for lung cancer.Molecular cancer therapeutics, ,14 (2 ),491-8

Woehrer, Adelheid; Lau, Ching C; Prayer, Daniela; Bauchet, Luc; Rosenfeld, Myrna; Capper, David; Fisher, Paul G; Kool, Marcel; Müller, Martin; Kros, Johan M; Kruchko, Carol; Wiemels, Joseph; Wrensch, Margaret; Danysh, Heather E; Zouaoui, Sonia; Heck, Julia E; Johnson, Kimberly J; Qi, Xiaoyang; O'Neill, Brian P; Afzal, Samina; Scheurer, Michael E; Bainbridge, Matthew N; Nousome, Darryl; Bahassi, El Mustapha; Hainfellner, Johannes A; Barnholtz-Sloan, Jill S Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014. Clinical neuropathology, ,34 (1 ),40-6

Wojton, Jeffrey; Meisen, Walter Hans; Jacob, Naduparambil K; Thorne, Amy Haseley; Hardcastle, Jayson; Denton, Nicholas; Chu, Zhengtao; Dmitrieva, Nina; Marsh, Rachel; Van Meir, Erwin G; Kwon, Chang-Hyuk; Chakravarti, Arnab; Qi, Xiaoyang; Kaur, Balveen (2014. )SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma.Oncotarget, ,5 (20 ),9703-9

Blanco, Víctor M; Chu, Zhengtao; Vallabhapurapu, Subrahmanya D; Sulaiman, Mahaboob K; Kendler, Ady; Rixe, Olivier; Warnick, Ronald E; Franco, Robert S; Qi, Xiaoyang (2014. )Phosphatidylserine-selective targeting and anticancer effects of SapC-DOPS nanovesicles on brain tumors.Oncotarget, ,5 (16 ),7105-18

Chu, Zhengtao; LaSance, Kathleen; Blanco, Victor; Kwon, Chang-Hyuk; Kaur, Balveen; Frederick, Malinda; Thornton, Sherry; Lemen, Lisa; Qi, Xiaoyang (2014. )In vivo optical imaging of brain tumors and arthritis using fluorescent SapC-DOPS nanovesicles.Journal of visualized experiments : JoVE, ,(87 ),

Olowokure, Olugbenga; Qi, Xiaoyang (2014. )Pancreatic cancer: current standards, working towards a new therapeutic approach.Expert review of anticancer therapy, ,14 (5 ),495-7

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y (2014. )Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.International journal of cancer, ,134 (1 ),9-20

Liu, Anping; Qi, Xiaoyang (2012. )Molecular Dynamics Simulations of DOPC Lipid Bilayers: The Effect of Lennard-Jones Parameters of Hydrocarbon Chains.Computational molecular bioscience, ,2 (3 ),78-82

Abu-Baker, Shadi; Chu, Zhengtao; Stevens, Ashley M; Li, Jie; Qi, Xiaoyang (2012. )Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles.Journal of cancer therapy, ,3 (4 ),321-326

Qi, Xiaoyang; Flick, Matthew J; Frederick, Malinda; Chu, Zhengtao; Mason, Rachel; DeLay, Monica; Thornton, Sherry (2012. )Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity.PloS one, ,7 (3 ),e33966

Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E (2017. )mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.Molecular cancer therapeutics, ,

Honors and Awards

11-01-2011 The News Record, University of Cincinnati, Cincinnati, OH, USA, "Cancer compound awaits trial"

09-01-2011 Co-Chair: Small Animal Imaging, Roundtable Session. Inaugural Imaging and Flow Cytometry Research Day, Cincinnati, OH, USA

07-01-2011 9 News Interview, OH, USA, "Local company making huge strides in developing cancer cure, free of side effects"

04-18-2011 Tri-State Outstanding Biotech Innovation Award for SapC-DOPS Technology Bexion Pharmaceuticals, USA

2011 Marquis Who's Who in America (65th Edition)

2010 The Enquirer Newspaper, Community Press, Cincinnati, OH "Cancer treatment shows promise"

2010 -To Present Member Cincinnati Chapter of the National Academy of Inventors

2010 Co-Chair Inorganic, Organic, Dendrimer, Natural or Artificial Biopolymer for Nanomedicine - Nanomedicine2010, Beijing, China

2010 Chair (2 Sessions) Neuro-oncological Cancer Drug Discovery; Gene, Tissue Chips, Lab-On-Chip and Microfluidics. The 3rd World Cancer Congress, Singapore

2010 China Innovative Drug Award

2008 Co-Chair Cancer Imaging: MRI, PET, and Molecular Imaging - The World Cancer Congress, Shanghai, China

2007 JiangSu Technology Innovation Award, China

2007 Changzhou First LingJunRenWu Award, China

AcademicKeys Who's Who in Medicine Higher Education (WWMHE) 2004, 2005, 2012

2012 CancerFree KIDS Foundation Interview, Cincinnati, OH, USA

Positions and Work Experience

2012 -To Present Associate Professor, Biomedical Engiineering Program in the College of Engineering (Secondary Faculty Member), University of Cincinnati,, Cincinnati, OH

2011 -To Present Associate Professor of Medicine, Division of Hematology-Oncology, Department of Internal Medicine, (Primary Faculty Member) , University of Cincinnati College of Medicine,, Cincinnati, OH

2011 -To Present Associate Professor, Division and Program in Human Genetics (Secondary Faculty Member), Children's Hospital Medical Center,, Cincinnati, OH

2008 -To Present Research Associate Professor, Division and Program in Human Genetics, Children's Hospital Medical Center, Cincinnati, OH

2007 -2009 Technology Liaison, Center for Technology Commercialization, Children's Hospital Medical Center, Cincinnati, OH

2006 -To Present Chairman of Scientific Advisory Board, Bexion Pharmaceuticals LLC, Cincinnati, OH

2001 -2008 Assistant Professor, Division and Program in Human Genetics, Children's Hospital Medical Center, Cincinnati, OH

1998 -2001 Research Assistant Professor, Division and Program in Human Genetics, Children's Hospital Medical Center, Cincinnati, OH

1996 -1998 Research Instructor, Division of Human Genetics, Children's Hospital Medical Center, Cincinnati, OH

1991 -1992 Research Associate, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK

1982 -1985 Lecturer, Biochemistry Department, Nanjing University, Nanjing, Jiangsu, P.R. China

Research and Practice Interests

My research is focused on developing a new saposin C (SapC) coupled dioleoylphosphatidylserine (DOPS) nanovesicle which has the potential to offer a targeted, potent, broad, and safe therapeutic agent for cancer patients. In preclinical studies, these stable nanovesicles (average diameter of 200 nm) have shown tumor-specific targeting activity and cancer-selective killing efficacy with significant inhibition of tumor growth in various animal tumor models. SapC-DOPS has striking absence of toxicity and adverse side effects in animals. In addition, these vesicles can deliver hydrophilic imaging probes, proteins, and RNA/DNA for cancer-selective targeting though specific binding of the surface exposed PS of tumor cell and vessels. Platform development of SapC-DOPS technology is my ongoing effort for cancer detection and therapy.

Preferred Information

Professor of Medicine, Co-Division Chief for Basic Science Research, Qi, Xiaoyang PhD

Contact Information

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue, Room 1314
Ohio, 45267
Phone: 513-558-4025
Fax: 513-558-6703
xiaoyang.qi@uc.edu

Headshot of Jason Shearn

Jason Shearn

Interim Department Chair , CEAS - Biomedical Eng

501 Engineering Research Cntr

513-556-4175

Education

Ph.D., University of Cincinnati Cincinnati, OH, 2002 (Engineering Mechanics)

M.S., University of Cincinnati Cincinnati, OH, 1998 (Engineering Mechanics)

B.S., Wright State University Dayton, OH, 1996 (Biomedical Engineering)

Research Support

09-2005 -08-2010 National Institute of Health (R01), Co-PI In Vitro Mechanical Stimulation to Enhance Tendon Repair $2,889,718

07-2009 -06-2010 University of Cincinnati Research Council, Co-PI Regional Compressive Mechanical Stimulation of Tendon Tissue Engineered Constructs to Enhance Tendon to Bone Insertional Healing $25,000

07-2008 -06-2010 National Institute of Health (R21), Investigator Angiogenic Peptide Scaffolds to Enhance Diabetic Wound Healing $193,704

06-2008 -09-2009 LifeCell, Inc., Co-Pl Design and Development of ACL Prosthesis: A Collaborative Project between the University of Cincinnati and LifeCell, Inc. $56,547

04-2006 -03-2008 National Institute of Health (R21) Robotic Simulation: Tissue Function with In Vivo Motions $401,365

01-2005 -12-2007 Department of Defense, Consultant Acellular Human Tissue Matrix Research: Matrix-mediated Regeneration of Orthopedic Tissues for Military Application $999,744

11-2003 -10-2004 University Research Council, PI Development of an in vitro device to deliver physiologically relavent mechanical signals to soft tissue repairs $6,500

12-2002 -11-2003 National Football League Charities, PI Analysis of factors for improving the surgical outcome of Posterior Cruciate Ligament Reconstructions: The effect of knee flexion and external loading on graft longevity $71,000

07-2009 -06-2014 National Institute of Health (R01), Investigator A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair $3,406,852

07-2010 -06-2014 National Institute of Health (R01), PI Establishing Design Criteria and Large Animal Model for Evaluation of ACL Repair $1,375,027

Grant: #2003-UC-29 Investigators:Shearn, Jason 02-19-2003 -02-18-2005 NFL Charities Analysis of Factors for Improving the Surgical Outcome Role:PI $142,001.00 Closed Level:Private Non-Profit

Publications
Peer Reviewed Publications

Kinneberg, Kirsten R C; Nirmalanandhan, Victor S; Juncosa-Melvin, Natalia; Powell, Heather M; Boyce, Steven T; Shearn, Jason T; Butler, David L (2010. )Chondroitin-6-sulfate incorporation and mechanical stimulation increase MSC-collagen sponge construct stiffness.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, ,28 (8 ),1092-9

Butler, David L; Gooch, Cynthia; Kinneberg, Kirsten R C; Boivin, Gregory P; Galloway, Marc T; Nirmalanandhan, V Sanjit; Shearn, Jason T; Dyment, Nathaniel A; Juncosa-Melvin, Natalia (2010. )The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons.Nature protocols, ,5 (5 ),849-63

Nirmalanandhan, Victor Sanjit; Juncosa-Melvin, Natalia; Shearn, Jason T; Boivin, Gregory P; Galloway, Marc T; Gooch, Cynthia; Bradica, Gino; Butler, David L (2009. )Combined effects of scaffold stiffening and mechanical preconditioning cycles on construct biomechanics, gene expression, and tendon repair biomechanics.Tissue engineering. Part A, ,15 (8 ),2103-2111

Butler, David L; Hunter, Shawn A; Chokalingam, Kumar; Cordray, Michael J; Shearn, Jason; Juncosa-Melvin, Natalia; Nirmalanandhan, Sanjit; Jain, Abhishek (2009. )Using functional tissue engineering and bioreactors to mechanically stimulate tissue-engineered constructs.Tissue engineering. Part A, ,15 (4 ),741-9

Nirmalanandhan, Victor S; Shearn, Jason T; Juncosa-Melvin, Natalia; Rao, Marepalli; Gooch, Cynthia; Jain, Abhishek; Bradica, Gino; Butler, David L (2008. )Improving linear stiffness of the cell-seeded collagen sponge constructs by varying the components of the mechanical stimulus.Tissue engineering. Part A, ,14 (11 ),1883-91

Nirmalanandhan, Victor S; Rao, Marepalli; Shearn, Jason T; Juncosa-Melvin, Natalia; Gooch, Cindi; Butler, David L (2008. )Effect of scaffold material, construct length and mechanical stimulation on the in vitro stiffness of the engineered tendon construct.Journal of biomechanics, ,41 (4 ),822-8

Butler, David L; Juncosa-Melvin, Natalia; Boivin, Gregory P; Galloway, Marc T; Shearn, Jason T; Gooch, Cynthia; Awad, Hani (2008. )Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, ,26 (1 ),1-9

Nirmalanandhan, Victor S; Dressler, Matthew R; Shearn, Jason T; Juncosa-Melvin, Natalia; Rao, Marepalli; Gooch, Cynthia; Bradica, Gino; Butler, David L (2007. )Mechanical stimulation of tissue engineered tendon constructs: effect of scaffold materials.Journal of biomechanical engineering, ,129 (6 ),919-23

Shearn, Jason T; Juncosa-Melvin, Natalia; Boivin, Gregory P; Galloway, Marc T; Goodwin, Wendy; Gooch, Cynthia; Dunn, Michael G; Butler, David L (2007. )Mechanical stimulation of tendon tissue engineered constructs: effects on construct stiffness, repair biomechanics, and their correlation.Journal of biomechanical engineering, ,129 (6 ),848-54

Juncosa-Melvin, Natalia; Shearn, Jason T; Boivin, Gregory P; Gooch, Cynthia; Galloway, Marc T; West, John R; Nirmalanandhan, Victor S; Bradica, Gino; Butler, David L (2006. )Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair.Tissue engineering, ,12 (8 ),2291-300

Shearn, Jason; Hellmann, Lauren; Boivin, Gregory Effect of initial cell-seeding density on postoperative cell number and dispersion.Tissue engineering, ,11 (11-12 ),1898-904

Shearn, Jason T; Grood, Edward S; Noyes, Frank R; Levy, Martin S (2005. )One- and two-strand posterior cruciate ligament reconstructions: cyclic fatigue testing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, ,23 (4 ),958-63

Butler, David L; Shearn, Jason T; Juncosa, Natalia; Dressler, Matthew R; Hunter, Shawn A (2004. )Functional tissue engineering parameters toward designing repair and replacement strategies. Clinical orthopaedics and related research, ,(427 Suppl ),S190-9

Shearn, Jason T; Grood, Edward S; Noyes, Frank R; Levy, Martin S (2004. )Two-bundle posterior cruciate ligament reconstruction: how bundle tension depends on femoral placement. The Journal of bone and joint surgery. American volume, ,86-A (6 ),1262-70

Herfat, Safa T; Shearn, Jason T; Bailey, Denis L; Greiwe, R. Michael; Galloway, Marc T; Gooch, Cynthia; Butler, David L Effect of Surgery to Implant Motion and Force Sensors on Vertical Ground Reaction Forces in the Ovine Model .Journal of Biomechanical Engineering, ,

Boguszewski, Daniel V; Shearn, Jason T; Wagner, Christopher T; Butler, David L Investigating the Effects of Anterior Tibial Translation on Anterior Knee Force in the Porcine Model: Is the Porcine Knee ACL Dependent? .Journal of Orthopaedic Research, ,

Mannor, Dana; Shearn, Jason T; Grood, Edward S; Noyes, Frank; Levy, Martin (2000. )An in vitro analysis of graft placement and tension .American Journal of Sports Medicine, ,28 (6 ),833 - 45

Schuler, Nisha B; Bey, Michael J; Shearn, Jason T; Butler, David L (2005. )Evaluation of an electromagnetic position tracking device for measuring in-vivo, dynamic joint kinematics: application to functional tissue engineering .Journal of Biomechanics, ,38 (10 ),2113 - 7

Sipes, Nisha S; Shearn, Jason T; Butler, David L (2005. )The effects of orientation, temperature, and displacement magnitude changes on the sonometrics system accuracy .Journal of Biomechanics, ,38 (12 ),2486 - 90

Invited Publications

Herfat ST, Shearn JT, Bailey DL, Greiwe RM, Galloway MT, Gooch C, Butler DL Effect of Surgery to Implant Motion and Force Sensors on Vertical Ground Reaction Forces in the Ovine Model .Journal of Biomechanical Engineering,

Boguszewski DV, Shearn JT, Wagner CT, Butler DL Investigating the Effects of Anterior Tibial Translation on Anterior Knee Force in the Porcine Model: Is the Porcine Knee ACL Dependent? .Journal of Orthopaedic Research,

Kinneberg KRC, Nirmalanandhan VS, Juncosa-Melvin N, Powell H, Boyce ST, Shearn JT, Butler DL (2010. )GAG Cross-Linking and Mechanical Stimulation Increase MSC-Collagen Sponge Construct Stiffness .Journal of Orthopaedic Research, 28 (8 ),1092-1099

Butler DL, Gooch C, Kinneberg KR, Boivin GP, Galloway MT, Nirmalanandhan VS, Shearn JT, Dyment NA, Juncosa-Melvin N (2010. )The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons .Nature Protocols, 5 (5 ),849-863

Nirmalanandhan VS, Juncosa-Melvin N, Shearn JT, Boivin GP, Galloway MT, Gooch C, Bradica G, Butler DL (2009. )Combined Effects of Scaffold Stiffening and Mechanical Preconditioning Cycles on Construct Biomechanics, Gene Expression, and Tendon Repair Biomechanics .Tissue Eng Part A, 15 (8 ),2103-2111

Butler DL, Hunter SA, Chokalingam K, Cordray MJ, Shearn J, Juncosa-Melvin N, Nirmalanandhan S, Jain A (2009. )Using functional tissue engineering and bioreactors to mechanically stimulate tissue-engineered constructs .Tissue Eng Part A, 15 (4 ),741-749

Nirmalanandhan VS, Shearn JT, Juncosa-Melvin N, Rao M, Gooch C, Jain A, Bradica G, Butler, DL (2008. )Improving linear stiffness of the cell-seeded collagen sponge constructs by varying the components of the mechanical stimulus .Tissue Engineering Part A, 14 (11 ),1883-1891

Nirmalanandhan VS, Rao M, Shearn JT, Juncosa-Melvin N, Gooch C, Butler, DL (2008. )Effect of scaffold material, construct length and mechanical stimulation on the in vitro stiffness of the engineered tendon construct .Journal of Biomechanics, 41 (4 ),822-828

Butler DL, Juncosa-Melvin N, Boivin GP, Galloway MT, Shearn JT, Gooch C, Awad H (2008. )Functional Tissue Engineering for Tendon Repair: A Multidisciplinary Strategy using Mesenchymal Stem Cells, Bioscaffolds and Mechanical Stimulation .Journal of Orthopaedic Research, 26 ,1-9

Shearn J, Juncosa-Melvin N, Butler D, Boivin G, Galloway M, Goodwin W, Gooch C (2007. )Mechanical Stimulation of Tendon Tissue Engineered Constructs: Effects on Construct Stiffness, Repair Biomechanics and their Correlation .Journal of Biomechanical Engineering, 126 ,848-854

Nirmalanandhan VS, Dressler MR, Shearn JT, Juncosa-Melvin N, Rao M, Gooch C, Bradica G, Butler, DL (2007. )Mechanical Stimulation of Tissue Engineered Tendon Constructs: Effect of Scaffold Material .Journal of Biomechanical Engineering, 129 ,919-923

Juncosa-Melvin N, Shearn J, Boivin G, Gooch C, Galloway M, West J, Nirmalanandhan V, Butler D (2006. )Effects of Mechanical Stimulation on the Biomechanics and Histology of Stem Cell - Collagen Sponge Constructs for Rabbit Patellar Tendon Repair .Tissue Engineering , 12 ,2291-2300

Nirmalanandhan VS, Shearn JT, Juncosa-Melvin N, Rao M, Jain A, Gooch C, Butler DL (2006. )Optimizing the mechanical stimulus in culture to improve construct biomechanics for tendon repair .Molecular and Cellular Biomechanics , 3 ,131-133

Butler DL, Juncosa-Melvin N, Boivin GP, Galloway MT, Gooch C, Shearn JT, Nirmalanandhan VS, Hunter SA, Chokalingam K, Frede C, Florer J, Wenstrup R (2006. )Functional tissue engineering to repair tendon & other musculoskeletal tissues .Molecular and Cellular Biomechanics, 3 ,127-129

Shearn J, Hellmann L, Boivin G (2005. )Effect of initial cell seeding density on final cell number and dispersion .Tissue Engineering, 11 ,1898-1904

Sipes NS, Shearn JT, Butler DL (2005. )The effects of orientation, temperature, and displacement magnitude changes on the sonometrics system accuracy .Journal of biomechanics , 38 ,2486-2490

Shearn J, Grood E, Noyes F, Levy M (2005. )One and Two-Bundle Posterior Cruciate Ligament Reconstructions: Cyclic Fatigue Testing .Journal of Orthopaedic Research , 23 ,958-963

Schuler N, Bey M, Shearn J, Butler D (2005. )Evaluation of an electromagnetic position tracking device for measuring in-vivo, dynamic joint kinematics: application to functional tissue engineering .Journal of Biomechanics , 38 ,2113-2117

Shearn J, Grood E, Noyes F, Levy M (2004. )Two-bundle posterior cruciate ligament reconstruction: a study of how bundle tension depends on femoral placement .Journal of bone and Joint Surgery. American Volume , 86 (6 ),1262-1270

Mannor D, Shearn J, Grood E, Noyes F, Levy M (2000. )Two-bundle posterior cruciate ligament reconstruction. An in vitro analysis of graft placement and tension .American Journal of Sports Medicine , 28 (6 ),833-845

Other Publications

Butler D, Shearn J, Juncosa N, Dressler M, Hunter S (2004. )Functional Tissue Engineering Parameters (FTEP) for Designing Repair and Replacement Strategies .Clinical Orthopaedics and Related Research , (427 ),S190-S199

Kinneberg, KRC Galloway MT, Butler DL, Shearn JT Effect of Implanting a Soft Tissue Autograft in a Central Third Patellar Tendon Defect: Biomechanical and Histological Comparisons .American Journal of Sports Medicine,

Dyment NA, Kazemi N, Aschbacher-Smith LE, Barthelery NJ, Kenter K, Gooch C, Shearn JT, Wylie C, Butler DL Transgenic Murine Full-Length Central Patellar Tendon Defect Model for Studying Midsubstance and Insertional Healing .Tissue Engineering,

Shearn JT, Kinneberg KRC, Dyment NA, Galloway MT, Kenter K, Wylie C, Butler DL Tissue Engineering Approaches to the Management of Tendon Injuries .Journal of Musculoskeletal and Neuronal Interactions,

Herfat MT, Boguszewski DV, Nesbitt RJ, Shearn JT Effect of Perturbing a Simulated In Vivo Motion on Knee and ACL Force .Journal of Biomechanics,

Herfat MT, Boguszewski DV, Shearn JT Primary and Secondary Contributions to the Knee Force during Simulated Gait in the Ovine .Journal of Biomechanics,

Herfat MT, Boguszewski DV, Shearn JT Comparison of Knee and ACL Force during Species Specific Gait: Human vs. Sheep .Journal of Biomechanics,

Boguszewski DV, Shearn JT, Wagner CT, Butler DL Effect of Graft Material on the Restoration of Knee Force Following ACL Reconstruction in a Porcine Model .Journal of Orthopaedic Research,

Boguszewski DV, Shearn JT, Wagner CT, Butler DL Effect of Graft Material on Knee Force Loss during Fatigue Testing Following ACL Reconstruction in a Porcine Model .Journal of Orthopaedic Research,

Boguszewski DV, Shearn JT, Wagner CT, Butler DL Effect of Graft Material on the Primary and Secondary Contributions to Knee Force Following ACL Reconstruction in a Porcine Model .Journal of Orthopaedic Research,

Kinneberg, KRC Galloway MT, Butler DL, Shearn JT Effect of Implanting a MSC-Collagen Gel Tissue Engineered Construct at the Tendon-Bone Interface Following Repair of the Central Third Patellar Tendon Defect with a Soft Tissue Autograft .American Journal of Sports Medicine,

Kinneberg, KRC Galloway MT, Butler DL, Shearn JT Effect of Time Post Surgery and Cells on the Repair of a Central Third Patellar Tendon Defect with a Soft Tissue Autograft .American Journal of Sports Medicine,

Book Chapter

Butler DL, Juncosa-Melvin N, Shearn J, Hunter S (2008 )Translational Approaches in Tissue Engineering and Regenerative Medicine Functional Tissue Engineering .(pp. 409-420).

Presentations
Invited Presentations

Boguszewski DV, Shearn JT, Wagner CT, Butler DL (2010. )Effect of ACL Reconstruction Graft Material on Joint Force Loss During Cyclic Fatigue Testing Using a 6-DOF Motion .Proceedings of the 2010 American Society of Mechanical Engineers Summer Bioengineering Conference ,

Dyment N, Shoemaker A, Chokalingam K, Gooch C, Shearn J, Wylie C, Butler D (2010. )Tensile Stimulation on Gene Expression and In Vitro Stiffness of Murine Tissue Engineered Constructs .Proceedings of the 2010 American Society of Mechanical Engineers Summer Bioengineering Conference,

Herfat M, Boguszewski D, Shearn J (2010. )Effect of Perturbing a Simulated In Vivo Motion on Knee and ACL Force .Proceedings of the 2010 Orthopaedic Research Society Meeting,

Kinneberg K, Drexler J, Dyment N, Powell H, Shearn J, Butler, David (2010. )Pore Size and Mechanical Stimulation Effect Stiffness and Col1 Expression of Collagen-C6S Constructs .Proceedings of the 2010 Orthopaedic Research Society Meeting,

Boguszewski DV, Shearn JT, Wagner CT, Butler DL (2010. )Effect of ACL Graft Material on the Restoration of Total Joint Force during a Simulated In Vivo Motion .Proceedings of the 2010 Orthopaedic Research Society Meeting,

Jain A, Kinneberg K, Nirmalanandhan VS, Shearn JT, Powell H, Butler DL (2009. )Regulation of Tendon Tissue Engineered Construct Stiffness by Culture Time, Mesenchymal Stem Cells and Mechanical Stimulation .Proceedings of the 2009 American Society of Mechanical Engineers Summer Bioengineering Conference,

Kinneberg KRC, Galloway MT, Shearn JT, Gooch C, Boivin GP, Butler DL (2009. )Autograft Repair of Central-Third PT Defect is Biomechanically and Histologically Inferior to Normal and TE Repair .Proceedings of the 2009 Orthopaedic Research Society Meeting,

Jain A, Shearn JT, Gooch C, Galloway MT, Boivin GP, Powell HM, Boyce ST, Butler DL (2009. )Effects of Mechanical Stimulation of MSC-Seeded Collagen-GAG Constructs on Construct and Repair Biomechanics .Proceedings of the 2009 Orthopaedic Research Society Meeting,

Dyment N, Boivin GP, Galloway M, Shearn J, Greiwe RM, Kenter K, Hasan S, Butler DL (2009. )Collagenase vs. Prostaglandin-E2 for Inducing Degenerative Changes in the Rabbit Patellar Tendon .Proceedings of the 2009 Orthopaedic Research Society Meeting,

Herfat ST, Boguszewski DV, Shearn JT, Butler DL (2009. )Total knee and ACL force for a stimulated in-vivo motion: A comparative study between human and ovine .Proceedings of the 2009 International Symposium on Ligament and Tendon Meeting,

Boguszewski DV, Herfat ST, Shearn JT, DL Butler (2009. )Force contributions in an ovine knee during simulated in-vivo motion .Proceedings of the 2009 International Symposium on Ligament and Tendon Meeting,

Boguszewski DV, Shearn JT, Wagner CT, Butler DL (2008. )Effect of anterior translation on anterior knee force in a porcine model .Proceedings of the 2008 American Society of Mechanical Engineers Summer Bioengineering Conference,

Boguszewski DV, Dyment NA, Bailey DL, Shearn JT, Butler DL (2008. )Biomechanical comparison of abdominal wall hernia repair materials .Proceedings of the 2008 American Society of Mechanical Engineers Summer Bioengineering Conference,

Dyment NA, Shearn JT, Galloway MT, Greiwe RM, Kenter K, Hasan SS, Butler DL, Boivin GP (2008. )Comparative histological and biomechanical effects of prostaglandin-e2 and bacterial collagenase on the rabbit patellar tendon .Proceedings of the 2008 American Society of Mechanical Engineers Summer Bioengineering Conference,

Nirmalanandhan V, Juncosa-Melvin N, Shearn J, Boivin G, Galloway M, Gooch C, Bradica G, Butler D (2008. )Combined Effects of Scaffold Stiffening and Mechanical Preconditioning Cycles on Construct Biomechanics, Gene Expression and Tendon Repair Biomechanics .Proceedings of the 2008 Orthopaedic Research Society Meeting ,

Herfat MT, Shearn JT, Bailey D, Mehl ME, Perry N, Galloway M, Greiwe M, Gooch C, Butler DL (2008. )The Effect of In Vivo Sensor Implantation in the Sheep Knee .Proceedings of the 2008 International Symposium on Ligament and Tendon Meeting,

Dyment N, Shearn J, Greiwe M, Kenter K, Boivin G, Galloway M, Hasan S, Butler D (2008. )Inducing Tendon Degeneration Using Prostaglandin-E2: In Vitro Release From Poly(lactic-co-glycolide) Films .Proceedings of the 2008 Orthopaedic Research Society Meeting,

Kinneberg KRC, Nirmalandhan VS, Bradica G, Shearn JT (2008. )Growth Factor Stimulation of MSC-Collagen Constructs to Improve Construct Linear Stiffness .Proceedings of the 2008 Orthopaedic Research Society Meeting,

Boguszewski DV, Shearn JT, Wagner CT, Butler DL (2008. )Effect of Anterior Translation on Total Knee Force in a Porcine Model .Proceedings of the 2008 International Symposium on Ligament and Tendon Meeting,

Jain A, Kinneberg K, Nirmalanandhan VS, Shearn JT, Powell HM, Boyce ST, Rao MB, Butler DL (2008. )The effects of mesenchymal stem cells and mechanical stimulation on in vitro biomechanics of collagen sponge constructs .Proceedings of the 2008 Orthopaedic Research Society Meeting,

Nirmalanandhan VS, Shearn JT, Juncosa-Melvin N, Rao M, Gooch C, Jain A, Bradica G, Butler DL (2007. )Effects of Mechanical Stimulation on the In Vitro Biomechanical Properties of MSC-Seeded Collegen Sponge Constructs .Proceedings of the 2007 Orthopaedic Research Society Meeting,

Shearn JT, Herfat MT, Bailey D, Mehl ME, Gooch C, Butler DL (2007. )Analysis of Level and Inclined Gait in a Sheep Model .Proceedings of the 2007 International Symposium on Ligament and Tendon Meeting,

Nirmalanandhan VS, Shearn JT, Juncosa-Melvin N, Rao M, Jain A, Gooch C, Butler DL (2007. )Optimizing the Mechanical Stimulus in Culture to Improve Construct Biomechanics for Tendon Repair .Proceedings of the 2007 Society for Physical Regulation in Biology and Medicine Conference,

Nirmalanandhan VS, Shearn JT, Rao M, Juncosa-Melvin N, Gooch C, Bradica G, Butler DL (2006. )Mechanical Stimulation of Tissue Engineered Tendon Constructs; Effect of Scaffold Materials .Proceedings of the 2006 American Society of Mechanical Engineers Summer Bioengineering Conference ,

Juncosa-Melvin N, Shearn JT, Boivin GP, Gooch C, Galloway MT, West JR, Bradica G, Butler DL (2006. )Effects of Mechanical Stimulation on the Biomechanics of Stem Cell - Collagen Sponge Constructs For Patellar Tendon Repair .Proceedings of the 2006 Orthopaedic Research Society Meeting ,

Nirmalanandhan, VS, Juncosa-Melvin, N, Shearn JT, Rao, M, Bradica, G, Butler, DL (2006. )Effects of Mechanical Stimulation on the In Vitro Biomechanical Properties of MSC-Seeded Collagen Sponge Constructs .Proceedings of the 2006 Orthopaedic Research Society Meeting,

Asif I, Franklin J, Shearn J, Kenter K, Stern P (2005. )The Use of Small Intestine Submucosa as a Scaffold in Flexor Tendon Repair .Proceedings of the 2005 American Orthopaedic Association Annual Meeting,

Shearn J, Juncosa-Melvin N, Butler D, Boivin G, Galloway M, Goodwin W, Gooch C (2005. )Effect Of In Vitro Mechanical Stimulation Of An Engineered Tendon Construct On The Repair Biomechanics And Tangent Stiffness .Proceedings of the 2005 American Society of Mechanical Engineers Summer Bioengineering Conference,

Butler D, Juncosa-Melvin N, Shearn J, Galloway M, Boivin G, Gooch C (2005. )Evolution Of An MSC-Based Tissue Engineered Construct To Improve Patellar Tendon Repair .Proceedings of the 2005 American Society of Mechanical Engineers Summer Bioengineering Conference,

Shearn J, Juncosa-Melvin N, Butler D, Boivin G, Galloway M, Goodwin W, Gooch C (2005. )Mechanical Stimulation of Tendon Tissue Engineered Constructs: Effects on Construct Stiffness, Repair Biomechanics and their Correlation .Proceedings of the 2005 International Symposium on Ligament and Tendon Meeting,

Shearn J, Goodwin W, Butler D (2005. )Effects of Collagenase on the Material Properties of Small Intestinal Submucosa .Proceedings of the 2005 International Symposium on Ligament and Tendon Meeting,

Shearn J, Noyes F (2005. )Posterior Cruciate Ligament: Effect of Deficiency and Reconstruction on Joint Kinematics .Proceedings of the 2005 International Symposium on Ligament and Tendon Meeting,

Shearn J, Gooch C, Butler D (2004. )Effects of load magnitude and frequency on the kinetics of scaffold degradation .Proceedings of the 2004 Midwest Tissue Engineering Consortium Meeting ,

Shearn J, Hellmann L, Boivin G (2004. )Effect of initial cell seeding density on final nuclear concentration and dispersion .Proceedings of the 2004 Orthopaedic Research Society annual meeting ,

Shearn J, Noyes F (2004. )Posterior cruciate ligament reconstruction: effect of flexion angle on graft longevity during cyclic fatigue testing .Proceedings of the 2004 Orthopaedic Research Society annual meeting,

Butler D, Shearn J, Juncosa N, Dressler M, Hunter S (11-2003. )Functional Tissue Engineering Parameters (FTEP) for Designing Repair and Replacement Strategies .Proceedings of the Association of Bone and Joint Surgeons Workshop,

Shearn J, Butler D, Boivin G (2003. )Morphological Analysis of Tissue Engineered Patellar Tendon Repairs .Proceedings of the 2003 Midwest Tissue Engineering Consortium Meeting,

Shearn J, Grood E, Noyes F, Levy M (2002. )Posterior cruciate ligament reconstruction: graft longevity and cyclic fatigue .Proceedings of the 2002 American Orthopaedic Society for Sports Medicine annual meeting,

Shearn J, Grood E, Noyes F, Levy M (2002. )The effects of one and two-bundle posterior cruciate ligament reconstruction on bundle tension .Proceedings of the 2002 Orthopaedic Research Society annual meeting,

Shearn J, Mannor D, Grood E, Levy M, Noyes F (1999. )Two-Bundle Posterior Cruciate Ligament Reconstruction. An In Vitro Analysis of Graft Placement and Tension .Proceedings of the 1999 ASME International Mechanical Engineering Congress and Exposition (Bioengineering Division),

Mannor D, Shearn J, Grood E, Noyes F (1999. )Biomechanics of Two Bundle Posterior Cruciate Ligament Reconstruction .Proceedings of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine 1999 Biennial Congress,

Grood E, Noyes F, Galloway M, Saddler S, Rubman M, Mannor D, Levy M, Shearn J, Knochenmuss D Biomechanics of PCL Reconstruction .Presented at the 8th European Society of Sports Traumatology, Knee Surgery and Arthroscopy ,

Lecture

Shearn JT (06-2010. )Establishing Design Criteria and Large Animal Model for Evaluation of ACL Repair .Department of Orthopaedic Surgery, University of Cincinnati.

Shearn JT (02-2005. )Posterior Cruciate Ligament Biomechanics .Cincinnati Sportsmedicine Orthopaedic Center.

Shearn JT (12-2004. )Isometric Length Tension Concepts of the ACL and PCL .Cincinnati Sportsmedicine Orthopaedic Center.

Shearn JT (10-2003. )Posterior Cruciate Ligament Biomechanics .Cincinnati Sportsmedicine Orthopaedic Center.

Shearn JT (12-2002. )Posterior Cruciate Ligament Biomechanics .Cincinnati Sportsmedicine Orthopaedic Center.

Honors and Awards

2007 Kappa Delta Ann Doner Vaughn Award

1997 University Research Council Summer Fellowship

1995 Tau Beta Pi Engineering Honor Society

1995 Electrical Manufacturing & Coil Winding Association Scholarship

1994 Millie Waddell Scholarship

1993 Armed Forces Electronics and Communications Association Scholarship

Student Advising

Andrea Lalley (Doctoral )Advisor

Rebecca Nesbitt (Doctoral )Advisor

Kirsten Kinneberg (Doctoral )Advisor

Daniel Boguszewski (Master )Advisor

Safa Herfat (Doctoral )Advisor

Nisha Schuler (Master )Advisor

Matthew Stonecash (Master )Advisor

Service

American Journal of Sports Medicine Reviewer Type:Other

Tissue Engineering Reviewer Type:Other

Journal of Orthopaedic Research Reviewer Type:Other

Journal of Biomechanics Reviewer Type:Other

Journal of Biomechanical Engineering Reviewer Type:Other

Journal of Biomedical Materials Research Reviewer Type:Other

2008 Midwest Tissue Engineering Consortium Meeting Co-Chair Type:Other 2008

Medical School Flex Applicants Reviewer Type:Other

Connections E program Other Type:Other

Graduate Student Research Forum Judge Type:Other

SEEBME Committee Member Type:Other

University Research Council Science and Engineering Committee Committee Member Type:Other

Positions and Work Experience

2006 -To Present Assistant Professor, establishing a program to improve the functional success of soft tissue repairs (tendon and ligament) by understanding the in vivo environment of native tissue and creating tissue engineered constructs, Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH

2002 -2006 Research Assistant Professor, establishing a program to improve the functional success of soft tissue repairs (tendon and ligament) by understanding the in vivo environment of native tissue and creating tissue engineered constructs , Department of Biomedical Engineering, University of Cincinnati , Cincinnati, OH

1998 -2002 Ph.D. Dissertation, worked with Dr. Edward S. Grood on investigating the effect of one and two-bundle posterior cruciate ligament reconstructions on the return of abnormal posterior translation during cyclic fatigue testing , Department of Aerospace Engineering and Engineering Mechanics, University of Cincinnati , Cincinnati, OH

1996 -1998 M.S. Thesis, worked with Dr. Edward S. Grood on investigating the effect of graft placement and graft tension on two-bundle posterior cruciate ligament reconstructions; developed and validated a method for adjusting and measuring graft bundle tension, Department of Aerospace Engineering and Engineering Mechanics, University of Cincinnati , Cincinnati, OH

Professional Affiliation

2010: Guest Lecturer Biomedical Engineering 601: Biomedical Engineering Survey “Establishing Design Criteria and Large Animal Model for Evaluation of ACL Repair” University of Cincinnati,

2010: Guest Lecturer Biomedical Engineering 621: Tissue Biomechanics “Tendon and Ligament: Function, Injury and Repair” University of Cincinnati,

2010: Lecturer Biomedical Engineering 521: Tissue Biomechanics Laboratory University of Cincinnati,

2010: Lecturer Biomedical Engineering 624: Joint Biomechanics University of Cincinnati,

2009: Guest Lecturer Biomedical Engineering 601: Biomedical Engineering Survey “Establishing Design Criteria and Large Animal Model for Evaluation of ACL Repair” University of Cincinnati,

2009: Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics University of Cincinnati,

2009: Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics University of Cincinnati,

2009: Lecturer Biomedical Engineering 624: Joint Biomechanics University of Cincinnati,

2008: Guest Lecturer Biomedical Engineering 601: Biomedical Engineering Survey “Establishing Design Criteria and Large Animal Model for Evaluation of ACL Repair” University of Cincinnati,

2008: Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics University of Cincinnati,

2008: Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics University of Cincinnati,

2008: Lecturer Biomedical Engineering 624: Joint Biomechanics University of Cincinnati,

2007: Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics University of Cincinnati,

2007: Lecturer Biomedical Engineering 602: Bioinstrumentation University of Cincinnati,

2007: Lecturer Biomedical Engineering 624: Joint Biomechanics University of Cincinnati,

2006: Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics University of Cincinnati,

2006: Lecturer Biomedical Engineering 602: Bioinstrumentation University of Cincinnati,

2005: Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics University of Cincinnati,

2004: Lecturer Biomedical Engineering 410: Biomaterials University of Cincinnati,

2003: Guest Lecturer Engineering Fundamentals 116: Engineering Concepts Biomedical Engineering Representative – Provided overview on biomedical engineering and demonstrated experimental procedures for the three rotations of students University of Cincinnati,

2003: Guest Lecturer Biomedical Engineering 601: Biomedical Engineering Survey “Soft Tissue Repair: Cruciate Ligament Reconstruction and Construct Development” University of Cincinnati,

2002: Guest Lecturer Engineering Fundamentals 100: Introduction to Engineering Biomedical Engineering Representative – Provided overview on biomedical engineering and demonstrated experimental procedures for the three rotations of students University of Cincinnati,

2002: Guest Lecturer Biomedical Engineering 601: Biomedical Engineering Survey “Cruciate Ligament Reconstruction” University of Cincinnati,

2002: Guest Lecturer Biomedical Engineering 220: Introduction to Human Body Dynamics “The Knee” University of Cincinnati,

2000: Guest Lecturer Engineering Mechanics 616: Kinematics of Biologic Joints “Instrumented Spatial Linkage: Use and Motion Calculation” University of Cincinnati,

Orthopaedic Research Society

American Society of Mechanical Engineers

Preferred Information

Interim Department Chair,

Headshot of David W. Wendell

David W. Wendell

Assoc Professor , CEAS - Environmental Eng & Science

732 Engineering Research Cntr

513-556-2482

Education

Ph.D, UCLA 2006 (Department of Biomedical Engineering )

M.S, Cornell University Ithaca, NY, 2002 (Department of Biological and Environmental Engineering )

B.S, Cornell University Ithaca, NY, 2000 (Department of Biological and Environmental Engineering)

Research Support

Grant: #CBET-1552456 Investigators:Wendell, David 03-01-2016 -02-28-2021 National Science Foundation CAREER: Engineering Biological Photocatalysts for Selective Disinfection Role:PI $500,000.00 Awarded Level:Federal

Grant: #NSF CBET-1509022 Investigators:Wendell, David 09-01-2015 -08-31-2018 National Science Foundation A Synthetic Bacterial Riboswitch Sensor for Microcystin Detection and Remediation Role:PI $299,894.00 Awarded Level:Federal

Grant: #CBET-1550093 Investigators:Wendell, David 09-01-2015 -08-31-2016 National Science Foundation EAGER: Anthropogenic Impact Assessment in Environmental Water with Human Hyper-Variable Region Mitochondrial DNA Role:PI $60,901.00 Awarded Level:Federal

Grant: #EEC-1404766 Investigators:Angelopoulos, Anastasios; Bhattacharya, Prabir; Cohen, Kelly; Franco, John; Guliants, Vadim; Kastner, Jeffrey; Kukreti, Anant; Kupferle, Margaret; Lu, Mingming; Nistor, Vasille; Sorial, George; Wei, Heng; Wendell, David 05-01-2014 -04-30-2017 National Science Foundation RET Site on "Challenge-Based Learning and Engineering Design Process Enhanced Research Experiences for Middle and High School In-Service Teachers." Role:Collaborator $498,949.00 Awarded Level:Federal

Grant: #EP-C-11-006/PEG-UC-11-0002 Investigators:Sorial, George; Wendell, David 08-01-2011 -09-29-2011 Environmental Protection Agency Environmental Impact of Nanomaterials Role:PI $4,003.00 Active Level:Federal

Grant: #Task Order # 0310000364 T1 / MSA 85X10431 Investigators:Wendell, David 03-15-2011 -03-15-2013 Metropolitan Sewer District of Greater Cincinnati Applying Molecular Tools for MST in the Duck Creek Watershed Role:PI $150,000.00 Active Level:Local Government

Grant: #Task Order # 0310000364 / MSA 85X10431 Investigators:Buchberger, Steven; Suidan, Makram; Wendell, David 03-15-2011 -08-31-2013 Metropolitan Sewer District of Greater Cincinnati Detention-Based Green Infrastructure (DBGI) Assessment for Combined Sewer Overflow Control Role:Collaborator $434,341.00 Active Level:Local Government

Grant: #ODOT 27834 Investigators:Esfandiari, Leyla; Helmicki, Arthur; Hunt, Victor; Wendell, David 10-07-2016 -04-07-2017 Federal Highway Administration Noninvasive method to detect Eastern Hellbender in the state of Ohio using the environmental DNA Role:Collaborator $98,541.11 Active Level:Federal

Grant: #30792 (FHWA), Hellbender Phase II Investigators:Esfandiari, Leyla; Wendell, David 03-20-2018 -03-20-2021 Ohio Department of Transportation Phase II: Non-Invasive Detection and Identification of Eastern Hellbender in Ohio Surface Waters Using Aquatic Environmental DNA Role:PI $659,659.69 Active Level:State of Ohio

Publications
Published Abstracts

Richard Brokamp, David Wendell, Carlo Montemagno (2008. )Engineering the Calvin Cycle: A Cell Free Photoconversion System for Biofuels Generation .[Abstracy]Co-Author

Jun Isobe, Zhilin Qu, Jordan Patti, David Wendell, Hyojick Choi, Carlo Montemagno (02-2006. )Preliminary Studies on the Effect of Size on the Action Potential of an Excitable Vesicle .[Abstracy] WSEAS Transactions on Systems, 5 (2 ),Co-Author

Hyo-Jick Choi, David Wendell, and Carlo D. Montemagno (2005. )Engineering Emergent Functionality Using Synthetic Biomimetic Polymers .[Abstracy]International Symposium on EcoTopia Science,

Jordan Patti, David Wendell, Jun Isobe, Carlo Montemagno (09-2004. )Integration of Biological Molecules and Synthetic Membranes to Create Excitable Vesicles .[Abstracy]Trends in Nanotechnology Abstract, Co-Author

Jinsoo Yi, David Wendell, Sergio Freire,Jacob Schmidt, Herc Nerves and Carlo Montemagno (08-2003. )Microsphere Dynamics for Actin Based Nanorobotic Motility .[Abstracy] Proceedings on Nanotechnology, 2 ,725Co-Author

Sergio Freire, David Wendell, Jin-Soo Yi, Hercules Neves, Jacob Schmidt, Toshikazu Hamasaki, and Carlo Montemagno (2003. )Development of a cantilever-based system for measurement of biopolymerization forces .[Abstracy]11th Foresight Conference on Molecular Nanotechnology, Co-Author

Peer Reviewed Publications

Jacob Todd, Bala Murali Venkatesan, Elizabeth Wurtzler, Rashid Bashir and David Wendell (2016. )Determining DNA Methylation State with an Engineered GP10-MeCP Nanopore .ACS Nano, ,

Elizabeth M. Wurtzler, Ranjani Ravi, Vikram Kapoor and David Wendell (2016. )Direct Isothermal RNA Detection and Quantification Using Duplex Specific Nuclease .ACS Central Science, ,

Shelli L. Frey, Jacob Todd, Elizabeth Wurtzler and David Wendell (2015. )A non-foaming proteosurfactant engineered from Ranaspumin-2 .Colloids and Surfaces B: Biointerfaces, ,133 ,239-245

Scott Keely, Nichole Brinkman, Brian Zimmerman, David Wendell, Kristen Wiles, Susan De Long, Sybil Sharville, and Jay Garland (2015. )Characterization of the Relative Importance of Human- and Infrastructure-Associated Bacteria in Graywater .Applied Microbiology, ,119 (1 ),289-301

Abderrahman Zehraoui, Vikram Kapoor, David Wendell, and George A. Sorial (2014. )Impact of Alternate Use of Methanol on n-Hexane Biofiltration and Microbial Community Structure Diversity .Journal of Biochemical Engineering , ,85 ,110-118

Brian Zimmerman, Nicholas Ashbolt, Jay Garland, Scott Keely and David Wendell (2014. )Human Mitochondrial DNA and Endogenous Bacterial Surrogates for Risk Assessment of Graywater Reuse .Environmental Science and Technology, ,48 (14 ),7993-8002

Abderrahman Zehraoui, David Wendell and George Sorial (2014. )Treatment of Hydrophobic VOCs in Trickling Bed Air Biofilter: Emphasis on Long Term Effect of Initial Alternate Use of Hydrophilic VOCs and Microbial Species Evolution .UAWM: Journal of the Air & Waste Management Association, ,64 (10 ),1102-1111

Vikram Kapoor, Ronald DeBry, Dominic Boccelli and David Wendell (2014. )Sequencing Human Mitochondrial Hypervariable Region II as a Molecular Fingerprint for Environmental Waters .Environmental Science and Technology, ,48 (18 ),10648-10655

Geshan Zhang, Elizabeth M. Wurtzler, Xuexiang He, Mallikarjuna N. Nadagouda, Kevin O'Shea, Said M. El-Sheikh, Adel A. Ismail, David Wendell and Dionysios D. Dionysiou (2014. )Identification of TiO2 photocatalytic destruction byproducts and reaction pathway of cylindrospermopsin .Applied Catalysis B, ,163 ,591-598

Vikram Kapoor, Tarja Pitka, Hodon ryu, Michael Elk, David Wendell, and Jorge Santo Domingo (2014. )Distribution of human-specific Bacteroidales and fecal indicators in an urban watershed impacted by sewage pollution using RNA and DNA based quantitative PCR assays .Applied and Environmental Microbiology, ,81 (10 ),91-99

Vikram Kapoor and David Wendell (2013. )Engineering Bacterial Efflux Pumps for Solar Powered Bioremediation of Surface Waters .Nano Letters, ,13 (5 ),2189-2193

Vikram Kapoor, Christopher Smith, Jorge SantoDamingo, Ting Lu and David Wendell (2013. )Correlative Assessment of Fecal Indicators Using Human Mitochondrial DNA as a Direct Marker .Environmental Science and Technology, ,47 (18 ),10485-10493

Ting Lu, Biju George, MaryLynn Lodor, Deborah Metz, James Parrott, James Fitzpatrick, Gary Hunter,Vikram Kapoor, and David Wendell (2013. )What is the right biomarker for water quality monitoring? .WE&T, ,52-55

Elizabeth Wurtzler and David Wendell (2013. )A Streptavidin-SOG Chimera for All-Optical Immunoassays .Biomacromolecules, ,15 (1 ),228-233

Jacob Todd, Brad Thielman, David Wendell (2012. )Detailed kinetic analysis of the Φ29 DNA packaging motor: Evidence for the coordinated inter-subunit ATPase activity of GP16 .Virology, ,432 (2 ),370-375

Cole Brokamp, Jacob Todd, Carlo Montemagno, David Wendell (2012. )Single and Aggregate Electrophysiology of Cx43 Hemichannels .PLoS ONE, ,7 (10 ),

Bala Murali Venkatesan, James Polans, Jeffrey Comer, Supriya Sridhar, David Wendell, Aleksei Aksimentiev, and Rashid Bashir (2011. )Lipid bilayer coated Al2O3 nanopore sensors: towards a hybrid biological solid-state nanopore .Biomed Microdevices, ,13 (4 ),671-682

David Wendell (2010. )Artificial photosynthesis processes as a means of producing biofuels .Biofuels , ,1 (6 ),855

David Wendell, Jacob Todd, and Carlo Montemagno (2010. )Artificial Photosynthesis in Ranaspumin-2 Based Foam .Nano Letters, ,10 (9 ),3231

David Wendell, Peng Jing, Jia Geng, Varuni Subramaniam, Tae Jin Lee, Carlo Montemagno, and Peixuan (2009. )Translocation of double-stranded DNA through membrane-adapted phi29 DNA motor protein nanopores .Nature Nanotechnology, ,4 (11 ),765

Hyo-Jick Choi, David Wendell, Carlo D. Montemagno (2007. )Advances in Nano Biotic/Abiotic Hybrid Systems: Protein-Based Engineered Devices .Nanobiotechnology, ,3 (2 ),66

David Wendell, Jordan Patti, and Carlo D. Montemagno (2006. )Using Biological Inspiration to Engineer Functional Nanostructured Materials .Small, ,2 (11 ),1324

Wendell, David W; Patti, Jordan; Montemagno, Carlo D (2006. )Using biological inspiration to engineer functional nanostructured materials.Small (Weinheim an der Bergstrasse, Germany), ,2 (11 ),1324-9

Other Publications

David W. Wendell (2006. )Nanoscale Networking: Engineering Polymer Vesicle Communication with Connexin .

Book Chapter

David Wendell, Dean Ho and Carlo Montemagno (2007 )Complexity and Emergence as Design Principles for Engineering Decentralized Nanoscale Systems Springer Handbook on Nanotechnology .(Author)

David Wendell, Eric Dy, Jordan Patti, and Carlo D. Montemagno (2007 )Nanobiotechnology II:More Concepts and Applications Biologically Inspired Hybrid Nanodevices .Wiley Press,Niemeyer, Christof and Mirkin, Chad A. Editors(Author)

Presentations
Invited Presentations

Wendell, D.W. (2010. )Engineering Hybrid Biotic/Abiotic Systems .ASME, Sharonville, OH.

Wendell, D.W. (02-2009. )Engineering and Fabricating Hybrid Biotic/Abiotic Systems .NSF Integrative Graduate Education and Research Traineeship Program, Cincinnati, Ohio.

Wendell, D.W. (12-2008. )Nanotechnology, what is it? .Glaucoma Foundation, New York City, NY.

Wendell, D.W. (11-2006. )Biologic Nanofabrication .Wright Patterson AFB, Dayton, OH.

Wendell. D (2011. )Light Activated Insulin Release from Pancreatic Beta Cells .Cincinnati Diabetes and Obesity Center, Cincinnati, OH.

Wendell. D (2015. )Engineering Energy Harvesting Remediation Materials with Synthetic Biology .University of Louisville, Louisville KY .

Wendell. D (2014. )Artificial Photosynthesis Using Hybrid Biotic/Abiotic Nano Architectures .The Royal Society, Chicheley Hall, London England.

Wendell. D (2014. )Engineering Remediation Materials and Sensors with Synthetic Biology .Miami University, Oxford OH.

Wendell D (2013. )Engineering Molecular Efflux Pumps for Bioremediation of Groundwater .National Groundwater Association Summit, San Antonio, Texas.

Wendell D (2013. )Nanoscale Biological Engineering .Global Thinker Series, Eastside Prep Seattle, WA .

Wendell D (2012. )Applying Molecular Tools in the Duck Creek Watershed .GCWW, Cincinnati, OH.

Wendell D (2011. )Engineering Biologically Functionalized Materials .BYU, Provo UT.

Wendell D (2011. )Artificial Photosynthesis within an Ranaspumin-2 based Foam .Global Artificial Photosynthesis Conference, Lord Howe Island, Australia.

Honors and Awards

2004 Trends in Nanotechnology Award Segovia, Spain

2004 -2005 University of California, Los Angeles, Bioengineering Departmental Fellowship

2010 International Earth Award, Grand Prize Winner and Future Category Winner

Student Advising

Brian Zimmerman (Master )Chair Status:Completed 2014

Christopher Smith (Master )Chair Status:In Progress 2016

Dan Li (Master )Chair Status:Completed 2011

Elizabeth Wurtzler (Doctoral )Chair Status:Completed 2016

Ranjani Ravi (Master )Chair Status:Completed 2014

Vikram Kapoor (Doctoral )Chair Status:Completed 2014

Positions and Work Experience

2010 -To Present Assistant Professor of Environmental Engineering, University of Cincinnati, Cincinnati, Ohio

2009 -To Present Research Assistant Professor of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio

2006 -2009 Post-doctoral scholar, Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio

2002 -2006 Graduate Student Researcher, Department of Biomedical Engineering, UCLA, Los Angeles, CA

2001 -2002 Graduate Student Researcher, Dept. Bio. & Env. Eng., Cornell University, Ithaca, NY

2000 -2001 Lab Technician , Boyce Thompson Institute, Cornell University, Ithaca, NY

Professional Affiliation

2007 -To Present: Support for Alternative and Renewable Energy Sources, founder and moderator, A Facebook cause, with over 85,000 members. All donations and fundraising benefit the non-profit organization: The Clean Energy Coalition, a Michigan based group dedicated to community education and alternative energy awareness.

2004 -To Present: Biophysical Society Member.

1998: thaca Science Center, water pressure module. Provided an acrylic installment to demonstrate water pressure as a function of depth. An interactive display designed for young children (ages 4-8) to explain hydraulic pressure.

1996 -To Present: American Indian Program, member. Promotes American Indian studies, community outreach, and various Native American social and cultural events.

1996 -1998: NCAA Football DI-AA, Cornell University, DT and DE

Patents and Inventions

Duplex Specific Nuclease as a Means of Isothermal Amplified RNA Detection Wendell, D., Ravi, R., Kapoor, V. , 2015

StrepMiniSog: A novel biotin-binding and singlet oxygen generating protein Wendell, D., Wurtzler, B. , 2014

Bacterial Efflux Pump and delta-Rhodopsin Wendell, D., Kapoor, V. , 2013

Bubble Architectures and Methods of Making and Using Thereof Montemagno, C. Wendell, D. Choi, H.J. , 2011

Engineered Rsn-2 for use as a biologically labile surfactant Wendell, D., Montemagno, C. , 2010

A Membrane Bound Nanopore from the Capsid Protein GP10 Wendell, D., Montemagno, C. , 2009

Contact Information

School of Energy, Environmental, Biological and Medical Engineering
2901 Woodside Dr., 732 Engineering Research Center
Ohio, 45221
Phone: (513) 556-2482
Fax: (513) 556-2599
wendeldw@uc.edu

Headshot of Patrick Whitlock

Patrick Whitlock

Asst Professor - Clin Aff , COM Orthopaedic Surgery

Childrens Hospital Bldg R

513-636-4787

Education

PhD, University of Cincinnati College of Engineering Cincinnati OH, 2005

Doctor of Medicine, Drexel University College of Medicine Philadelphia, PA, 2005

Wake Forest Health Sciences Winston-Salem, NC, 2012 (Residency)

EuropeanTraveling Fellowship, Maurice E. Muller Foundation of North America Switzerland, Denmark, Italy, 2013 (Hip Reconstruction)

Fellowship, Los Angeles Children's Hospital Los Angeles, CA, 2014 (Pediatric Orthopaedic Surgery)

Publications
Peer Reviewed Publications

Whitlock, Patrick W; DeAnglis, Ashley P; Ackley, Kathryn L; Clarson, Stephen J; Retzinger, Gregory S (2002. )Distribution of silicon/e in tissues of mice of different fibrinogen genotypes following intraperitoneal administration of emulsified poly(dimethylsiloxane) [correction of poly(dimethysiloxane)].Experimental and molecular pathology, ,72 (2 ),161-71

Whitlock, P W; Clarson, S J; Retzinger, G S (1999. )Fibrinogen adsorbs from aqueous media to microscopic droplets of poly(dimethylsiloxane) and remains coagulable. Journal of biomedical materials research, ,45 (1 ),55-61

Clarson S.; Patwardhan S.; Stone M.; Whitlock P. (01-01-2008. )Synthetic peptides derived from the diatom Cylindrotheca fusiformis: Kinetics of silica formation an .ACS Symposium Series, ,999 ,412-433

Brott L.; Clarson S.; Glawe D.; Naik R.; Rodriguez F.; Stone M.; Whitlock P. (02-03-2003. )Controlled formation of biosilica structures in vitro.Chemical Communications, ,9 (2 ),238-239

Ackley K.; Clarson S.; DeAnglis A.; Retzinger G.; Whitlock P. (09-07-2002. )Erratum: Distribution of silicon/e in tissues of mice of different fibrinogen genotypes following in.Experimental and Molecular Pathology, ,72 (3 ),243

Brott L.; Clarson S.; Kirkpatrick S.; Naik R.; Pikas D.; Stone M.; Tomlin D.; Whitlock P. (09-20-2001. )Ultrafast holographic nanopatterning of biocatalytically formed silica.Nature, ,413 (6853 ),291-293

Clarson S.; Retzinger G.; Whitlock P. (08-01-1999. )Functionality of fibrinogen bound to PDMS .American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, ,40 (2 ),770-771

Seyler TM, Bracey DN, Plate JF, Lively MO, Mannava S, Smith TL, Saul JM, Poehling GG, Van Dyke ME, Whitlock PW (2016. )The Development of a Xenograft-Derived Scaffold for Tendon and Ligament Reconstruction Using a Decellularization and Oxidation Protocol.Arthroscopy, ,(Sept 27 ),

Buchler L, Schwab JM, Whitlock PW, Beck M, Tannast M (2016. )Intraoperative Evaluation of Acetabular Morphology in Hip Arthroscopy Comparing Standard Radiography vs. Fluoroscopy: A Cadaver Study .Arthroscopy, ,6 (Jun ),1030-7

Abdelnasser MK, Klenke FM, Whitlock PW, Khalil AM, Khalifa YE, Ali HM, Siebenrock KA (2015. )Management of pelvic discontinuity in revision total hip arthroplasty: a review of the literature .Hip Int, ,2 (Mar-Apr ),120-6

Whitlock PW, Seyler TM, Northam CN, Smith TL, Poehling GG, Koman LA, Van Dyke ME (2013. )The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis .Knee Surg Sports Traumatol Arthrosc, ,21 (7 ),1610-9

Mannavva S, Plate JF, Tuohy CJ, Seyler TM, Whitlock PW, Curl WW, Smith TL, Saul KR (2012. )A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructractural properties and cell infiltration .J Bone Joint Surg Am, ,94 (16 ),1458-67

Mannava S, Plate JF, Whitlock PW, Callahan MF Seyler TM, Koman LA, Smith TL, Tuohy CJ (2011. )Evaluation in vivo rotator cuff muscle function after acute and chronic detachment of the supraspinatus tendon: an experimental study in an animal model .J Bone Joint Surg Am, ,93 (18 ),1702-11

Seyler, Thorsten M; Bracey, Daniel N; Plate, Johannes F; Lively, Mark O; Mannava, Sandeep; Smith, Thomas L; Saul, Justin M; Poehling, Gary G; Van Dyke, Mark E; Whitlock, Patrick W (2017. )The Development of a Xenograft-Derived Scaffold for Tendon and Ligament Reconstruction Using a Decellularization and Oxidation Protocol.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, ,33 (2 ),374-386

Büchler, Lorenz; Schwab, Joseph M; Whitlock, Patrick W; Beck, Martin; Tannast, Moritz (2016. )Intraoperative Evaluation of Acetabular Morphology in Hip Arthroscopy Comparing Standard Radiography Versus Fluoroscopy: A Cadaver Study.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, ,32 (6 ),1030-7

Abdelnasser, Mohammad K; Klenke, Frank M; Whitlock, Patrick; Khalil, Aly M; Khalifa, Yaser E; Ali, Hassan M; Siebenrock, Klaus A Management of pelvic discontinuity in revision total hip arthroplasty: a review of the literature.Hip international : the journal of clinical and experimental research on hip pathology and therapy, ,25 (2 ),120-6

Whitlock, Patrick W; Seyler, Thorsten M; Northam, Casey N; Smith, Thomas L; Poehling, Gary G; Koman, L Andrew; Van Dyke, Mark E (2013. )Effect of cyclic strain on tensile properties of a naturally derived, decellularized tendon scaffold seeded with allogeneic tenocytes and associated messenger RNA expression. Journal of surgical orthopaedic advances, ,22 (3 ),224-32

Mannava, Sandeep; Plate, Johannes F; Tuohy, Christopher J; Seyler, Thorsten M; Whitlock, Patrick W; Curl, Walton W; Smith, Thomas L; Saul, Katherine R (2013. )The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, ,21 (7 ),1610-9

Whitlock, Patrick W; Seyler, Thorsten M; Parks, Griffith D; Ornelles, David A; Smith, Thomas L; Van Dyke, Mark E; Poehling, Gary G (2012. )A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration.The Journal of bone and joint surgery. American volume, ,94 (16 ),1458-67

Mannava, Sandeep; Plate, Johannes F; Whitlock, Patrick W; Callahan, Michael F; Seyler, Thorsten M; Koman, L Andrew; Smith, Thomas L; Tuohy, Christopher J (2011. )Evaluation of in vivo rotator cuff muscle function after acute and chronic detachment of the supraspinatus tendon: an experimental study in an animal model.The Journal of bone and joint surgery. American volume, ,93 (18 ),1702-11

Stabile, Kathryne J; Odom, Devin; Smith, Thomas L; Northam, Casey; Whitlock, Patrick W; Smith, Beth P; Van Dyke, Mark E; Ferguson, Cristin M (2010. )An acellular, allograft-derived meniscus scaffold in an ovine model.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, ,26 (7 ),936-48

Stone, Austin V; Ma, Jianjun; Whitlock, Patrick W; Koman, L Andrew; Smith, Thomas L; Smith, Beth P; Callahan, Michael F (2007. )Effects of Botox and Neuronox on muscle force generation in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, ,25 (12 ),1658-64

Whitlock, Patrick W; Smith, Thomas L; Poehling, Gary G; Shilt, Jeffrey S; Van Dyke, Mark (2007. )A naturally derived, cytocompatible, and architecturally optimized scaffold for tendon and ligament regeneration.Biomaterials, ,28 (29 ),4321-9

Mahirogullari, Mahir; Ferguson, Cristin M; Whitlock, Patrick W; Stabile, Kathryne J; Poehling, Gary G (2007. )Freeze-dried allografts for anterior cruciate ligament reconstruction.Clinics in sports medicine, ,26 (4 ),625-37

Preferred Information

MD, PhD