The Sinner lab aims to understand the molecular mechanisms underlying the patterning of the mammalian respiratory tract during normal development and its relevance to congenital disease.
We are focused on finding answers for four critical questions:
- How does the developing respiratory tract epithelium induce differentiation of mesenchymal lineages, including muscle, cartilage, and vasculature of the large airways and the lungs?
- How are the muscle and cartilage established in the developing trachea and bronchi?
- Are there genetic components of human trachea and bronchi malformations?
- How many of the mechanisms/genes identified in the mouse are also mediating trachea and bronchi formation in humans?